Patents by Inventor Winton D. Jones

Winton D. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
    Patent number: 6004959
    Abstract: The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).
    Type: Grant
    Filed: April 18, 1997
    Date of Patent: December 21, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Winton D. Jones, Fred L. Ciske, Robert J. Dinerstein, Keith A. Diekema
  • 5-acyl-2-(1H)-pyridinoes
    Patent number: 5428045
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: August 25, 1993
    Date of Patent: June 27, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 5212314
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: May 18, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 5212315
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: July 29, 1991
    Date of Patent: May 18, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Treatment of multi-drug resistant tumors with quinolyl-and isoquinolyloxazole-2-ones
    Patent number: 5190957
    Abstract: This invention relates to quinolyloxazole-2-ones which are useful in the treatment of multi-drug resistant tumors. The quinoloyloxazole-2-ones act to prevent drug resistance and thus allow conventional chemotherapeutic agents to kill tumor cells as if drug resistance were not present.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: March 2, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Sai P. Sunkara, Winton D. Jones
  • Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
    Patent number: 5182293
    Abstract: This invention relates to pyridinyloxazole-2-ones which are useful in the treatment of multi-drug resistant tumors. The pyridinyloxazole-2-ones act to prevent drug resistance and thus allow conventional chemotherapeutic agents to kill tumor cells as if drug resistance were not present.
    Type: Grant
    Filed: October 3, 1990
    Date of Patent: January 26, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Sai P. Sunkara, Winton D. Jones
  • 5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure
    Patent number: 5118696
    Abstract: Novel 5-acyl-2-(1H)pyrdinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: November 9, 1990
    Date of Patent: June 2, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Prevention of glycoprotein enveloped virus infectivity by pyridinyloxazole-2-ones
    Patent number: 5063238
    Abstract: This invention relates to pyridinyloxazole-2-ones which are useful anti-enveloped virus agents by virtue of their ability to act as protein kinase C inhibitors. These derivatives are disclosed to be effective in treating enveloped virus infections including HIV infections and are thus useful in the treatment of AIDS and ARC.
    Type: Grant
    Filed: October 3, 1990
    Date of Patent: November 5, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Sai P. Sunkara, Winton D. Jones
  • Prevention of glycoprotein enveloped virus infectivity by quinolyl- and isoquinolyloxazole-2-zones
    Patent number: 5061715
    Abstract: This invention relates to quinolyloxazole-2-ones which are useful anti-enveloped virus agents by virtue of their ability to act as protein kinase C inhibitors. These derivatives are disclosed to be effective in treating enveloped virus infections including HIV infections and are thus useful in the treatment of AIDS and ARC.
    Type: Grant
    Filed: October 3, 1990
    Date of Patent: October 29, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Sai P. Sunkara, Winton D. Jones
  • Certain alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 5043449
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: February 8, 1990
    Date of Patent: August 27, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Process for preparing quinoline aldehyde and ketone derivatives
    Patent number: 4999431
    Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: March 12, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, Richard C. Dage, George P. Claxton, Hsien C. Cheng, Phillip J. Robinson
  • Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure
    Patent number: 4992452
    Abstract: Novel 5-acyl-2-(1H)-pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: February 12, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors
    Patent number: 4990519
    Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: February 5, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, George P. Claxton, Richard C. Dage, Hsien C. Cheng, Phillip J. Robinson
  • Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 4920229
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: April 24, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Qunolyloxazole-2-ones useful as proteinkinase C inhibitors
    Patent number: 4886811
    Abstract: This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
    Type: Grant
    Filed: October 24, 1988
    Date of Patent: December 12, 1989
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, George P. Claxton, Richard C. Dage, Hsien C. Cheng, Phillip J. Robinson
  • Cardiotonic alkanoyl and aroyl oxazolones
    Patent number: 4866182
    Abstract: Alkanoyl or aroyl oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: February 18, 1988
    Date of Patent: September 12, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Winton D. Jones, Richard C. Dage
  • Cardiotonic phenyl oxazolones
    Patent number: 4866085
    Abstract: Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.
    Type: Grant
    Filed: November 24, 1987
    Date of Patent: September 12, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, George P. Claxton, Winton D. Jones, Jr.
  • Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties
    Patent number: 4853395
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: November 17, 1987
    Date of Patent: August 1, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 4849522
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: March 10, 1988
    Date of Patent: July 18, 1989
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Cardiotonic tricyclic oxazolones
    Patent number: 4803210
    Abstract: Tricyclic oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: February 7, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, George P. Claxton, Richard C. Dage