Patents by Inventor Winton D. Jones

Winton D. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates
    Patent number: 4769380
    Abstract: Novel 3-carboxy- and 3-carbalkoxy-5-benzoyl-2(1H)-pyridinones as well as the pharmaeutically acceptable salts thereof are cardiotonic agents useful in the treatment of heart failure.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: September 6, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Jr., Richard A. Dage, Richard A. Schnettler
  • Cardiotonic tricyclic imidazolones
    Patent number: 4743607
    Abstract: Tricyclic imidazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: May 10, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, George P. Claxton, Richard A. Schnettler, Richard C. Dage
  • Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
    Patent number: 4732982
    Abstract: This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.
    Type: Grant
    Filed: February 28, 1986
    Date of Patent: March 22, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents
    Patent number: 4731371
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: May 27, 1986
    Date of Patent: March 15, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard A. Schnettler, Richard C. Dage
  • Cardiotonic phenyl oxazolones
    Patent number: 4728661
    Abstract: Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: March 1, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Winton D. Jones, Jr., George P. Claxton
  • Cardiotonic heterocyclic oxazolones
    Patent number: 4698353
    Abstract: Heterocyclic oxazolones enhance myocardial contractile force and cardiac function and are used as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: October 6, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Winton D. Jones, Jr., George P. Claxton
  • Cardiotonic thiazolones
    Patent number: 4670450
    Abstract: Thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: June 2, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schenttler, Winton D. Jones, Jr., George P. Claxton
  • 5-Acyl-2-(1H)-pyridinones
    Patent number: 4568751
    Abstract: Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.
    Type: Grant
    Filed: April 29, 1983
    Date of Patent: February 4, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, Richard C. Dage, Richard A. Schnettler
  • Antisecretory 1,2,4-triazole-3-thiols
    Patent number: 4411905
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is H or NH.sub.2 ; R.sub.2 is C.sub.1-6 straight or branched chain alkyl; --CH.sub.2 OH; --(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --CH.sub.3 ; phenyl; or --(CH.sub.2).sub.p NH.sub.2 ;n is 1-3;m is 0-3; andp is 1-5;and the pharmaceutically acceptable acid addition salts of those compounds of basic character,have antisecretory activity.
    Type: Grant
    Filed: June 15, 1981
    Date of Patent: October 25, 1983
    Assignee: Richardson-Merrell Inc.
    Inventors: William L. Albrecht, Winton D. Jones
  • Tetrahydro-7a-(optionally substituted phenyl)-1H-pyrrolo[1,2-b][1,2,4]-triazole-2(3H)-thiones
    Patent number: 4358457
    Abstract: Compounds of the formula ##STR1## wherein R is H or C.sub.1-5 straight or branched chain alkyl; R.sub.1 is H, C.sub.1-10 straight or branched chain alkyl, allyl or phenyl; and R.sub.2 is phenyl or phenyl substituted with F, Cl, C.sub.1-5 straight or branched chain alkyl, di-F, di-Cl or di-Br; and the pharmaceutically acceptable acid addition salts thereof; are useful as muscle relaxants, anticonvulsants and analgesics.
    Type: Grant
    Filed: July 27, 1981
    Date of Patent: November 9, 1982
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Winton D. Jones, John M. Kane, Francis P. Miller
  • Muscle-relaxant 1,3,4-thiadiazin-2-amines
    Patent number: 4309426
    Abstract: A method of achieving a muscle-relaxing effect in a patient comprises administering to a patient in which a muscle relaxing effect is desired an amount effective to achieve a muscle-relaxing effect of a compound of the formula ##STR1## wherein R is H, or C.sub.1-7 straight or branched chain alkyl;R.sub.1 is H, C.sub.1-7 straight or branched chain alkyl, allyl or phenyl;R.sub.2 is phenyl, phenyl monosubstituted with F, Cl, C.sub.1-4 straight or branched chain alkyl or phenyl disubstituted in the 2- and 4-positions with Cl or C.sub.1-4 straight or branched chain alkyl; andR.sub.3 is H or C.sub.1-4 straight or branched chain alkyl, with the proviso that when R.sub.3 is straight or branched chain alkyl, R.sub.2 is unsubstituted phenyl;or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: November 20, 1980
    Date of Patent: January 5, 1982
    Assignee: Richardson-Merrell Inc.
    Inventors: Winton D. Jones, Jr., Francis P. Miller
  • 5-(Chlorophenyl)-6H-1,3,4-thiadiazine-2-amines
    Patent number: 4289767
    Abstract: Compounds of the formula ##STR1## wherein R is H, C.sub.1-5 or 7 -straight or branched chain alkyl or allyl and R.sub.1 is H or Cl andthe pharmacologically acceptable acid addition salts thereof are pharmacologically active as anticonvulsant and anxiolytic agents.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: September 15, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Winton D. Jones, Francis P. Miller
  • 5-(Optionally substituted phenyl)-6H-1,3,4-thiadiazine-2-amines
    Patent number: 4272532
    Abstract: A method of inducing sedation in a patient comprises administering to a patient in which sedation is desired an amount effective for inducing sedation of a compound of the formula ##STR1## wherein R is H, or C.sub.1-5 or 7 -straight or branched chain alkyl:R.sub.1 is H, C.sub.1-5 or 7 -straight or branched chain alkyl or allyl;R.sub.2 is phenyl or phenyl substituted with F, Cl, Br, NO.sub.2, C.sub.1-5 straight or branched chain alkyl, C.sub.1-5 straight or branched chain alkoxy, 2,4-di-Cl, 2,4-di-F or 2,4-di-Br, with the proviso that when the phenyl group is monosubstituted with F, the F atom is not in the o-position; andR.sub.3 is H or C-1-5 straight or branched chain alkyl, with the proviso that when R.sub.3 is straight or branched chain alkyl, R.sub.2 is unsubstituted phenyl; ora pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: June 9, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Winton D. Jones, Francis P. Miller
  • 1,2,4-Triazole-3-thiols as antisecretory agents
    Patent number: 4230715
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is H or NH.sub.2 ;R.sub.2 is C.sub.1-6 straight or branched chain alkyl; --CH.sub.2 OH; --(CH.sub.2).sub.n --O--(CH.sub.2).sub.m --CH.sub.3 ; phenyl; or --(CH.sub.2).sub.p NH.sub.2 ;n is 1-3;m is 0-3; andp is 1-5;and the pharmaceutically acceptable acid addition salts of those compounds of basic character, have antisecretory activity.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: October 28, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: William L. Albrecht, Winton D. Jones
  • Triazolocycloalkylhydrothiadiazine derivatives
    Patent number: 3954981
    Abstract: Novel triazolocycloalkylhydrothiadiazines and their preparation, which are useful as antisecretory agents, central nervous system stimulants, and central nervous system depressants, are disclosed.
    Type: Grant
    Filed: April 28, 1975
    Date of Patent: May 4, 1976
    Assignee: Richardson-Merrell Inc.
    Inventors: William L. Albrecht, Winton D. Jones