Abstract: A light-triggered transponder includes one or more of photo cells, a clock recovery circuit and a reverse antenna system. The clock recovery circuit (CRC) includes a photoconductor with a source terminal, a drain terminal for receiving a voltage, the photoconductor resistance varying with received light intensity. The CRC is configured to generate a recovered clock. A reverse antenna system connected to at least one photo cell and configured to transmit data. The photoconductor configured to produce a modulated voltage signal from an incident modulated light incident. The CRC can include an amplifier coupled to the source terminal of the photoconductor via a capacitor for receiving the modulated voltage signal and outputting an analog signal generated from the voltage signal. The CRC can include an inverter coupled to the amplifier and configured to digitize the analog signal of the amplifier.

Abstract: A light-triggered transponder includes one or more of photo cells, a clock recovery circuit and a reverse antenna system. The clock recovery circuit (CRC) includes a photoconductor with a source terminal, a drain terminal for receiving a voltage, the photoconductor resistance varying with received light intensity. The CRC is configured to generate a recovered clock. A reverse antenna system connected to at least one photo cell and configured to transmit data. The photoconductor configured to produce a modulated voltage signal from an incident modulated light incident. The CRC can include an amplifier coupled to the source terminal of the photoconductor via a capacitor for receiving the modulated voltage signal and outputting an analog signal generated from the voltage signal. The CRC can include an inverter coupled to the amplifier and configured to digitize the analog signal of the amplifier.

Abstract: A light-triggered transponder includes one or more of photo cells, a clock recovery circuit and a reverse antenna system. The clock recovery circuit (CRC) includes a photoconductor with a source terminal, a drain terminal for receiving a voltage, the photoconductor resistance varying with received light intensity. The CRC is configured to generate a recovered clock. A reverse antenna system connected to at least one photo cell and configured to transmit data. The photoconductor configured to produce a modulated voltage signal from an incident modulated light incident. The CRC can include an amplifier coupled to the source terminal of the photoconductor via a capacitor for receiving the modulated voltage signal and outputting an analog signal generated from the voltage signal. The CRC can include an inverter coupled to the amplifier and configured to digitize the analog signal of the amplifier.

Abstract: Provided among other things is a method of affixing a small, single chip to a plastic item, the chip having a top surface having length and width dimensions, and having a height, the method comprising: (1) vacuum adhering a top-oriented surface of the chip to a probe of outer dimensions comparable to or smaller than those of the length and width; (2) conveying heat to the chip via the probe such that a bottom-oriented surface of the chip is sufficiently hot to melt the plastic; (3) applying via the probe the chip to the plastic such that the chip embeds in the plastic; and (4) releasing the chip from the probe, wherein the largest of the length and width is about 500 microns or less, and height is no more than about the smallest of length and width.

Abstract: An apparatus and system having an optical integrated circuit (referred to herein as an OMTP) configured for power on during discovery and optically communicating with the OMTP reader for the purpose of extracting data.

Abstract: A light-triggered transponder includes one or more of photo cells, a clock recovery circuit and a reverse antenna system. The clock recovery circuit (CRC) includes a photoconductor with a source terminal, a drain terminal for receiving a voltage, the photoconductor resistance varying with received light intensity. The CRC is configured to generate a recovered clock. A reverse antenna system connected to at least one photo cell and configured to transmit data. The photoconductor configured to produce a modulated voltage signal from an incident modulated light incident. The CRC can include an amplifier coupled to the source terminal of the photoconductor via a capacitor for receiving the modulated voltage signal and outputting an analog signal generated from the voltage signal. The CRC can include an inverter coupled to the amplifier and configured to digitize the analog signal of the amplifier.

Abstract: A light-triggered transponder includes one or more of photo cells, a clock recovery circuit and a reverse antenna system. The clock recovery circuit (CRC) includes a photoconductor with a source terminal, a drain terminal for receiving a voltage, the photoconductor resistance varying with received light intensity. The CRC is configured to generate a recovered clock. A reverse antenna system connected to at least one photo cell and configured to transmit data. The photoconductor configured to produce a modulated voltage signal from an incident modulated light incident. The CRC can include an amplifier coupled to the source terminal of the photoconductor via a capacitor for receiving the modulated voltage signal and outputting an analog signal generated from the voltage signal. The CRC can include an inverter coupled to the amplifier and configured to digitize the analog signal of the amplifier.

Abstract: Provided among other things is an indexed library on one or more solid phase supports of a substantial representation of all theoretical peptide combinations having a certain length of 3 to 5 amino acids, or a combination thereof, and being formed with a certain collection of amino acids that numbers as follows: # of amino acids in Length collection 3 6 to 18 4 4 to 18 5 4 to 18 the peptides spaced apart from the supports sufficiently such that one or more of the peptides binds an antibody composition substantially more strongly than others.

Abstract: An apparatus and system having an optical integrated circuit (referred to herein as an OMTP) configured for power on during discovery and optically communicating with the OMTP reader for the purpose of extracting data.

Abstract: A light-triggered transponder includes one or more of photo cells, a clock recovery circuit and a reverse antenna system. The clock recovery circuit (CRC) includes a photoconductor with a source terminal, a drain terminal for receiving a voltage, the photoconductor resistance varying with received light intensity. The CRC is configured to generate a recovered clock. A reverse antenna system connected to at least one photo cell and configured to transmit data. The photoconductor configured to produce a modulated voltage signal from an incident modulated light incident. The CRC can include an amplifier coupled to the source terminal of the photoconductor via a capacitor for receiving the modulated voltage signal and outputting an analog signal generated from the voltage signal. The CRC can include an inverter coupled to the amplifier and configured to digitize the analog signal of the amplifier.

Abstract: Provided among other things is a method of applying force to a macromolecule such as dsDNA to make an end more accessible, such as more accessible to ligation.

Abstract: Provided among other things is a method of affixing a small, single chip to a plastic item, the chip having a top surface having length and width dimensions, and having a height, the method comprising: (1) vacuum adhering a top-oriented surface of the chip to a probe of outer dimensions comparable to or smaller than those of the length and width; (2) conveying heat to the chip via the probe such that a bottom-oriented surface of the chip is sufficiently hot to melt the plastic; (3) applying via the probe the chip to the plastic such that the chip embeds in the plastic; and (4) releasing the chip from the probe, wherein the largest of the length and width is about 500 microns or less, and height is no more than about the smallest of length and width.

Abstract: Provided among other things is a method to make a sensor enzyme that comprises: (1) identifying an area on the surface of an enzyme having one to three targeted loops including one linked loop, the loops having 3 or more residues without backbone hydrogen bonding and having up to 10 residues designated as the targeted loop, (2) creating an expression library of more than a thousand recombinant clones expressing recombinant enzyme wherein a segment within one, two or all of the targeted loops are replaced with from three to fourteen amino acid residue segments, (3) performing selection or screening of such library for (a) binding to molecule target substance; (b) enzymatic activity; and (c) allosteric modulation of enzymatic activity by the target substance, and (4) identifying one or more recombinant clones expressing recombinant enzyme that is allosterically modulated by the target substance.

Abstract: The present invention provides a novel assay that allows high-throughput screening of chemical compounds for the inhibition of binding between EF-Tu and tRNA.

Abstract: Provided is a method of synthesis comprising: (I) providing separate reaction sequences to TABs; (II) utilizing reaction vessels configured to react a separate combinatorial building block with a moiety on a surface of a TAB; and (III) operating one or more TAB sorters comprising a TAB reader, a sorting tree comprising valves or switches and sorting nodes, and a monitor configured to detect TAB location, wherein the operating comprises serially conducting: (a) reacting distinct combinatorial building blocks in the reaction chambers with surfaces of TABs distributed in the reaction chambers; (b) operating a controller to operate the TAB sorters to segregate the TABs to allocations appropriate for the next assigned reaction, the operating including recycling TABs with ambiguous identity back through the sorter; and (c) repeating steps (a) and (b) as needed to complete 30% or more of the assigned sequences.

Abstract: Provided among other things is an analyzer for use with tabs placed in a vessel including: a stochastic sampling device adapted to receive the vessel; a light beam source adapted to enter the moving vessel and selectively illuminate tabs; an analytical signal receiver adapted to receive a signal indicative of an analytical process occurring on the surface of the tab as the tab is selectively illuminated; a tab ID receiver adapted to collect ID data from the tabs in coordination with their selective illumination; and a controller for associating identified tabs with analytical signals.

Abstract: Provided in an embodiment is a high resolution method of detecting prostate cancer comprising utilizing a solid phase immunoassay to determine if a patient fluid shows a MIC-1 value in Zone M. In an embodiment, the method comprises conducting a sandwich assay in an assay device that, if the determined value is in Zone M, automatically generates a report stating that a high risk of prostate cancer exists. Also provided in an embodiment a high resolution method of detecting prostate cancer comprising utilizing a solid phase immunoassay to determine if a patient serum shows a MIC-1 value and a PSA value in Zone A (defined below) or, if utilized, Zone B. In an embodiment, the method comprises conducting a sandwich assay in an assay device that, if the determined value is in Zone A and/or Zone B, automatically generates a report stating that a high risk of prostate cancer exists.

Abstract: An apparatus and system having an optical integrated circuit (referred to herein as an OMTP) configured for power on during discovery and optically communicating with the OMTP reader for the purpose of extracting data.

Abstract: Provided herewith, among other things, is an assembly comprising a test tube with an affixed very small, light-triggered transponder (“MTP”).

Abstract: Provided among other things is an indexed library on one or more solid phase supports of a substantial representation of all theoretical peptide combinations having a certain length of 3 to 5 amino acids, or a combination thereof, and being formed with a certain collection of amino acids that numbers as follows: # of amino acids Length in collection 3 6 to 18 4 4 to 18 5 4 to 18 the peptides spaced apart from the supports sufficiently such that one or more of the peptides binds an antibody composition substantially more strongly than others