Abstract: The present invention relates to spray-dried amorphous powders which contain a pharmaceutical active substance and a matrix-forming agent, preferably a polymer, sugar or sugar alcohol in an amount of ?20-60% (w/w). The powders have a moisture content which is less than 1.2% (w/w), preferably less than 1% (w/w). The present invention also relates to special methods of preparing such powders and methods of administering them by inhalation.

Abstract: A whole skin model is made by a process for the production of a whole skin model comprising the steps of: (a) providing a poorly soluble collagen obtained from collagen-containing tissue; (b) forming a homogeneous aqueous suspension by mixing the collagen with an aqueous medium; (c) forming a first matrix (A) by lyophilizing the collagen suspension; (d) forming a second matrix (B) by cross-linking the collagen in the first matrix (A) to form a mechanically stabilized second matrix (B); (e) sowing fibroblasts onto the second matrix (B) and allowing the fibroblasts to grow; (f) sowing keratinocytes onto the second matrix B and allowing the keratinocytes to grow; (g) further cultivating the fibroblasts and keratinocytes growing in and on matrix (B) to form a complete whole skin model comprised of a dermal and epidermal part.

Abstract: The present invention relates to compositions, preferably powdered compositions such as spray-dried or freeze-dried powders, containing an antibody or and antibody derivative and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are those which contain lactosucrose or a combination of glucosyl and maltosyl sucrose.

Abstract: The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are such that they contain glucosyl and maltosyl sucrose.

Abstract: The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-Glu-saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu-saccharose (maltosyl sucrose) in combination with at least one further excipient. The other excipient is preferably an amino acid, a peptide and/or a mono-, di- and/or oligosaccharide, wherein the oligosaccharide may be a second 1,4 O-linked saccharose derivative, provided that this is different from the first.

Abstract: Disclosed are powders, preferably spray-dried powders, which contain a pharmaceutical active substance and low-molecular dextran as excipient. Also disclosed are processes for preparing such powders and methods of administering them by inhalation.

Abstract: Disclosed are methods of making bioactive BMP-2 microparticles and methods of using the microparticles.

Abstract: A flat carrier having a power supply, for example in the form of a coil. The carrier is characterized by an electroluminescent device that contains two flat electrodes lying above one another and an electroluminescent paste located between the electrodes. The electrodes of the electroluminescent device are connected to terminals of the power supply, which can be implemented, for example, as a coil or battery.

Abstract: An arrangement for storing and displaying coins and the like includes a rigid mounting device having one or more openings for receiving a coin, the coin being mounted in the opening such that both sides of the coin may be viewed, the mounting means having coin-engaging portions which are made of a material which does not adversely affect the coin.