Abstract: The invention relates to novel compounds having the general formula Ib wherein R1, R2, R1, R4, R5 and Z are as described herein, composition including the compounds and methods of using the compounds.

Abstract: The invention relates to a printing machine with hybrid printing technology for printing on a continuous material web.

Abstract: A method of workload management in a Kubernetes (K8s) environment may include obtaining, by a digital twin (DT) representing a cluster state, performance data of at least one K8s cluster, generating, by the DT, a behavioral model based on the performance data, determining, by a horizontal pod autoscaler (HPA) controller, a HPA configuration based on the behavioral model and implementing, by an HPA of the at least one K8s cluster, the determined HPA configuration

Abstract: Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. This approach has been applied to identify biomarker signatures that correlate with response of cancer patients to platinum-based chemotherapy. Described herein are data structures, data processing, and machine learning models to predict a probability of benefit of a treatment for a disease or disorder of a subject having a particular set of biomarkers, as well as an exemplary application of such a model to precision medicine, e.g., to methods for selecting a treatment based on a molecular profile, e.g., a treatment comprising platinum therapy.

Abstract: The invention relates to a method for controlling an inverter which is electrically connected to an electric motor, having the following steps: defining a modulated voltage (S1) for the inverter, said voltage being based on a first switching frequency, for operating the electric motor with a current, wherein the current has an electric frequency; determining the electric frequency (S2); changing the first switching frequency (S4) on which the modulated voltage is based to a second switching frequency if a value pair consisting of electric frequency and first switching frequency, or a value pair consisting of electric frequency and a sideband of the first switching frequency, is within at least one defined disturbance range (S3).

Abstract: A power semiconductor chip having: a semiconductor component body; a multilayer metallization arranged on the semiconductor component body; and a nickel layer arranged over the semiconductor component body. The invention further relates to a method for producing a power semiconductor chip and to a power semiconductor device. The invention provides a power semiconductor chip which has a metallization to which a copper wire, provided without a thick metallic coating, can be reliably bonded without damage to the power semiconductor chip during bonding.

Abstract: Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. This approach has been applied to identify biomarker signatures that correlate with response of cancer patients to platinum-based chemotherapy. Described herein are data structures, data processing, and machine learning models to predict a probability of benefit of a treatment for a disease or disorder of a subject having a particular set of biomarkers, as well as an exemplary application of such a model to precision medicine, e.g., to methods for selecting a treatment based on a molecular profile, e.g., a treatment comprising platinum therapy.

Abstract: Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. This approach has been applied to identify biomarker signatures that strongly correlate with response of colorectal cancer patients to FOLFOX. Described herein are data structures, data processing, and machine learning models to predict effectiveness of a treatment for a disease or disorder of a subject having a particular set of biomarkers, as well as an exemplary application of such a model to precision medicine, e.g., to methods for selecting a treatment based on a molecular profile, e.g., a treatment comprising administration of 5-fluorouracil/leucovorin combined with oxaliplatin (FOLFOX) or with irinotecan (FOLFIRI).

Abstract: Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. This approach has been applied to identify biomarker signatures that strongly correlate with response of colorectal cancer patients to FOLFOX. Described herein are data structures, data processing, and machine learning models to predict effectiveness of a treatment for a disease or disorder of a subject having a particular set of biomarkers, as well as an exemplary application of such a model to precision medicine, e.g., to methods for selecting a treatment based on a molecular profile, e.g., a treatment comprising administration of 5-fluorouracil/leucovorin combined with oxaliplatin (FOLFOX) or with irinotecan (FOLFIRI).

Abstract: Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. Here, we used molecular profiling data to identify biomarker signatures that predict a tumor primary lineage or organ group.

Abstract: The invention relates to a method for controlling an inverter which is electrically connected to an electric motor, having the following steps: defining a modulated voltage (S1) for the inverter, said voltage being based on a first switching frequency, for operating the electric motor with a current, wherein the current has an electric frequency; determining the electric frequency (S2); changing the first switching frequency (S4) on which the modulated voltage is based to a second switching frequency if a value pair consisting of electric frequency and first switching frequency, or a value pair consisting of electric frequency and a sideband of the first switching frequency, is within at least one defined disturbance range (S3).

Abstract: Comprehensive molecular profiling provides a wealth of data concerning the molecular status of patient samples. Such data can be compared to patient response to treatments to identify biomarker signatures that predict response or non-response to such treatments. This approach has been applied to identify biomarker signatures that strongly correlate with response of colorectal cancer patients to FOLFOX. Described herein are data structures, data processing, and machine learning models to predict effectiveness of a treatment for a disease or disorder of a subject having a particular set of biomarkers, as well as an exemplary application of such a model to precision medicine, e.g., to methods for selecting a treatment based on a molecular profile, e.g., a treatment comprising administration of 5-fluorouracil/leucovorin combined with oxaliplatin (FOLFOX) or with irinotecan (FOLFIRI).

Abstract: Method and apparatus for the electrodeposition of a contact metal layer on contact areas of semiconductor components in a wafer assemblage. The method comprises: a) providing a wafer having components having at least one pn junction; b) arranging a non-conductive homogenizing device with respect to the first surfaces of the components, and an electrical contact device at a second surface of the wafer; c) introducing the wafer into an electroplating bath having an electrode, wherein the surface thereof consists at least partly of a first contact metal, and wherein the first surface of the components is in contact with the electroplating bath; d) applying a voltage to the electrode and to the contact device, as a result of which current flows between the electrode and the contact device, through the electroplating bath and the component and contact metal is thus deposited at the first contact areas of the components.

Abstract: Devices and methods for providing commentary for multiple points of interests utilize audio communication devices having an optic code reader, a microcontroller, a transmitter/receiver, a storage module and a speaker and/or headphone jack. Two or more audio communication devices may be synced to the same channel. A primary audio communication device sends a signal that triggers a dependent audio communication device to play a prerecorded commentary regarding a selected point of interest in a language selected by a person using the dependent audio communication device. A map having icons representing points of interest includes optic codes embedded within the icons. When an audio communication device scans an icon with an optic reader, a triggering signal causes the audio communication device and any dependent audio communication devices to play a corresponding commentary and a language selected by a user.

Abstract: The invention relates to a method (300) and a device (170) for reducing mechanical loads in a powertrain (100). An electric machine (130) is provided as the drive assembly of the powertrain (100), and an inverter (110) is provided in order to output a multiphase output voltage for supplying the electric machine (130). The method (300) has the following steps: determining (320) the multiphase output voltage (UA) for operating the electric machine (130); adding (340) a specifiable voltage (VU) and the specified output voltage (UA); and outputting (350) the sum (SU) of the multiphase output voltage (UA) and the specifiable voltage (VU) in order to supply the electric machine (130).

Abstract: A semiconductor diode includes a semiconductor body, having a first main area formed from an inner area, on which a first contact layer is arranged, and from an edge area, a current path from the first contact layer to a second contact layer arranged on a second main area situated opposite the first main area, wherein the semiconductor diode, by virtue of the configuration of the first contact layer or of the semiconductor body, is formed such that upon current flow, such current flows through a current path having the greatest heating per unit volume, and which proceeds from a further partial area of the inner area, wherein the further partial area is arranged on the other side of a boundary of an inner partial area of the inner area, said inner partial area preferably being arranged centrally, with respect to an outer partial area adjoining said inner partial area.

Abstract: A power semiconductor chip having: a semiconductor component body; a multilayer metallization arranged on the semiconductor component body; and a nickel layer arranged over the semiconductor component body. The invention further relates to a method for producing a power semiconductor chip and to a power semiconductor device. The invention provides a power semiconductor chip which has a metallization to which a copper wire, provided without a thick metallic coating, can be reliably bonded without damage to the power semiconductor chip during bonding.

Abstract: Methods and devices for wirelessly transmitting content from a source device to a sink device are disclosed. The method comprises: identifying one or more data types associated with a display frame displayed on the source device; selecting a transmission format for the display frame in accordance with the one or more identified data types, wherein the transmission format is selected from the group consisting of screencasting, graphics processing unit (GPU) processing, or GPU processing with media streaming; and sending visual information representing the display frame in the transmission selected transmission format to the sink device. One or a combination of latency, image/video quality, and power consumption associated with the wireless transmission may be used to adapt the wireless transmission.

Abstract: A semiconductor diode includes a semiconductor body, having a first main area formed from an inner area, on which a first contact layer is arranged, and from an edge area, a current path from the first contact layer to a second contact layer arranged on a second main area situated opposite the first main area, wherein the semiconductor diode, by virtue of the configuration of the first contact layer or of the semiconductor body, is formed such that upon current flow, such current flows through a current path having the greatest heating per unit volume, and which proceeds from a further partial area of the inner area, wherein the further partial area is arranged on the other side of a boundary of an inner partial area of the inner area, said inner partial area preferably being arranged centrally, with respect to an outer partial area adjoining said inner partial area.

Abstract: Devices and methods for providing commentary for multiple points of interests utilize audio communication devices having an optic code reader, a microcontroller, a transmitter/receiver, a storage module and a speaker and/or headphone jack. Two or more audio communication devices may be synced to the same channel. A primary audio communication device sends a signal that triggers a dependent audio communication device to play a prerecorded commentary regarding a selected point of interest in a language selected by a person using the dependent audio communication device. A map having icons representing points of interest includes optic codes embedded within the icons. When an audio communication device scans an icon with an optic reader, a triggering signal causes the audio communication device and any dependent audio communication devices to play a corresponding commentary and a language selected by a user.