Abstract: The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.

Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Abstract: The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).

Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

Abstract: A method for frame and frequency synchronization of an OFDM signal and a signal for transmitting an OFDM signal is described, the purpose of which is to impress a pilot phase profile that is then used at the receiving end for frame and frequency synchronization on pilots which are already contained in the OFDM signal for channel estimation. This has the advantage that no additional transmission capacity has to be used for the synchronization. The method according to the present invention is initiated by a rough time synchronization unit connected upline, which searches for the beginning of the guard interval in the OFDM signal. The comparison between a stored pilot phase profile and the received subcarrier symbol is performed using a cross-correlation, whose result is then evaluated to determine the frame and frequency synchronization.

Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Abstract: The invention relates to a method and a device for synchronizing one or more remote clocks (2) to a central clock (1) via a bi-directional satellite radio link (9.1, 9.2). Time and data signals are exchanged via suitable transmitting (8, 12) and receiving devices (5, 11) at both ends of the radio link. From time difference measurements (6, 14) at both ends a control signal (17) is derived in such a manner that the clock (2) installed directly in the remote ground station devices (11) synchronizes in state and rate to the central clock (1) with the aid of the two-way method (TWSTFT, Two-Way Satellite Time and Frequency Transfer). The user has access to time signals (18) which directly represent the state of the central clock (1). The signals used for the time measurement are also used for data transmission, resulting in a system operating in real time in which the control deviations (15, 16) of the remote clock are accessible at both ends of the system.

Abstract: Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Abstract: Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Abstract: The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).

Abstract: The invention relates to a glass printing ink and a glass printing lacquer comprising at least one pigment, at least one photoinitiator and at least two resins. One resin is an epoxy resin having an average molecular weight based on bisphenol A, diluted in a UV hardening monomer. Another resin is a resin which contains free functional amino, hydroxy, epoxy, acid, acid anhydride and/or acrylate groups. The invention also relates to the use of the glass printing ink and glass printing lacquer when printing a glass substrate and to a method for printing a glass substrate.

Abstract: A film or strip product is provided with a positioning feature formed to aid a user in differentiating or distinguishing or otherwise identifying one or more features of the film or strip product. The positioning feature thus may be used to facilitate proper or desired use of the film product upon identification of a desired feature thereof. In one embodiment, the positioning feature is configured to aid in properly orienting and/or positioning and/or applying the film or strip product. The film or strip product may provide a therapeutic affect to a desired treatment site, and may require positional orientation before application to the treatment site, and/or positional orientation with respect to the treatment site. Various positioning features that may serve such function include visual or tactile features that either visually or tactilely indicate to a user sufficient information about the film product to permit the user to use and/or apply and/or orient the film product as desired or required.

Abstract: The invention relates to a method for individually packing sheet or film-type materials in an automatic manner, said materials consisting of at least one material layer, in a packing unit with marked contents. A marking (40) made of a waxy marking material is applied to a warmed first packing material strip (20). The sheet or film-type material (10) is fixed to the marking wit surface thereof, whereby the roughness of the surface thereof is greater than the roughness of the surface of the first packing material strip. A second packing material strip (30) is applied to the sheet or film-type material and is connected to the first packing material strip in order to form a closed packing unit. The packing unit (35) is cooled and the marking is separated from the first packing material strip. A secure packing method and a marking for sheet or film-type materials are developed according to said inventive method.

Abstract: A glass printing ink and glass printing lacquer are prepared, which contain at least one photoinitiator, at least one resin and at least one additional substance. The resin is an epoxy resin based on bisphenol A, diluted in a UV-curing monomer, or a resin with functional groups containing free functional amino, hydroxy, epoxy, acid, acid anhydride and/or acrylate groups, or a combination of the epoxy resin with the resin with functional groups. The at least one additional substance is a wax. The use of the glass printing ink and glass printing lacquer in printing a glass substrate and processes for the printing of a glass substrate are also described.

Abstract: This invention pertains to methods and devices for producing products in web form. In particularly advantageous embodiments, the instant invention relates to methods and devices for forming films by coating a coating mass formed from organic raw materials in an aqueous basis onto a reusable transfer support web to form a composite. The composite is then dried and the dried coating transferred onto a intermediate support material. The dried coating and intermediate support material are directed to a winding station. Upon separation from the dried coating, the dried reusable transfer support web may be directed to treatment and cleaning stations and is subsequently reused.

Abstract: In the global protection of objects structured with electronic components, security devices, e.g., in a vehicle, become active by at least one component, and/or information within at least one component that is essential for operation of the vehicle is deactivated irreversibly and or erased, so that even a disassembly or bridging of the component concerned can achieve no effect, since acquisition of a functional replacement part is not available. The components can, for example, be placed in the motor electronics, the steering column lock, the door lock, and/or the key, and through miniaturization of the receiver, any electronic device can be protected including, among other things, radio telephones, (Euro-)checkcards and cash cards, credit cards, telephone cards, keys to electronic systems, mobile electronic devices, such as cassette recorder, CD players, clocks, computers, etc.

Abstract: A process and device for manufacturing a primary unit pack of a wafer. A laminate comprising a carrier sheet and an active substance film is cross-cut at a predetermined length, detached from the carrier sheet, guided between two packaging material webs and, conveyed to a sealing station along with the packaging material webs. The packaging material webs are sealed to form a bag that is separated from the webs. The process includes detaching the carrier sheet from the active substance film, pulling the carrier sheet forward over the predetermined length of the wafer, simultaneously guiding the active substance film, which has been detached from the carrier sheet, without mechanical stress, the front end being between the packaging material webs which are in a resting condition, and is received and fixed by packaging material webs and transversely cut to form a wafer.

Abstract: The invention describes compounds of the general formula I a process for their manufacture, compositions containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. These compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.

Abstract: The invention describes compounds of the general formula I a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.