Abstract: This document provides methods and materials for treating multiple system atrophy. For example, methods and materials for using autologous mesenchymal stem cells (e.g., adipose derived mesenchymal stem cells) to treat multiple system atrophy are provided.

Abstract: This document provides methods and materials for treating multiple system atrophy. For example, methods and materials for using autologous mesenchymal stem cells (e.g., adipose derived mesenchymal stem cells) to treat multiple system atrophy are provided.

Abstract: This document provides methods and materials for treating multiple system atrophy. For example, methods and materials for using autologous mesenchymal stem cells (e.g., adipose derived mesenchymal stem cells) to treat multiple system atrophy are provided.

Abstract: A light guide for guiding light for an HMD includes at least one input coupling structure and at least one output coupling structure. The output coupling structure can be oriented such that for all the rays that are coupled out by the output coupling structure and for which the wave vector k has a negative ratio ky/kxz after they have been coupled out, the wave vector k in the light guide has a ratio of ky/kxz of greater than ?0.2, and/or that for all the rays that are coupled out by the output coupling structure and for which the wave vector k has a positive ratio ky/kxz after they have been coupled out, the wave vector k in the light guide has a ratio of ky/kxz of less than +0.2.

Abstract: This document provides methods and materials for treating multiple system atrophy in a mammal. Specifically, the methods comprises intrathecally administering to the mammal a composition comprising autologous mesenchymal stem cells (e.g. adipose deprived mesenchymal stem cells) to treat multiple system atrophy. Further disclosed is the composition comprising from about 5×10(6) to about 5×10(8) autologous mesenchymal stem cells.

Abstract: The disclosure relates to a device for mounting two spherical optical components. The device includes a first holder, having a receptacle for a first optical element with a first spherical convex face with a first radius, and a second holder, having a receptacle for a second optical element with a second spherical optical concave face with a second radius. At least one of the holders has a supporting face with a third radius, and the first holder can be supported on the second holder such that the radii have a common center point when the first optical element is held in the first holder and the second optical element is held in the second holder.

Abstract: Provided is an optical element with a Fresnel structure with several Fresnel segments. Each Fresnel segment has an optically active facet, the shape of which is part of a predetermined surface. The predetermined surfaces of the optically active facets differ in terms of their curvature profile.

Abstract: An arrangement for microscopy, having an illumination optical unit with an illumination objective for illuminating a specimen on a specimen carrier. An optical axis of the illumination objective lies in a plane which includes an illumination angle that differs from zero with the normal of a specimen plane and the illumination is implemented in the plane. A detection optical unit with a detection objective is located in a detection beam path. The optical axis of the detection objective includes a detection angle that differs from zero with the normal of the specimen plane. The illumination objective and/or the detection objective has an illumination correction element. A meniscus lens is located between the specimen carrier and the illumination and detection objectives being arranged both in the illumination beam path and in the detection beam path.

Abstract: An optical transmission assembly for transmitting a source image includes a waveguide assembly, an incoupling assembly for coupling light emitted from the source image into the waveguide assembly, and an outcoupling assembly for coupling the light guided in the waveguide assembly out of the waveguide assembly. The light emitted from the source image and coupled into the waveguide assembly can be propagated between the incoupling assembly and the outcoupling assembly in the waveguide assembly by means of a total reflection. The incoupling assembly has at least one diffractive incoupling grating which is inclined by an angle (?) ranging from 20° to 60° relative to a normal of a boundary surface of the waveguide assembly, and/or the outcoupling assembly has at least one diffractive outcoupling grating which is inclined by an angle (?) ranging from 20° to 60° relative to a normal of a boundary surface of the waveguide assembly.

Abstract: A spectacle lens has a body containing at least one diffraction structure, which is made to extend in the body on a body surface. The diffraction structure is formed by a spatial modulation of the refractive index n(x, y) dependent on the location in the body surface. The spatial modulation of the refractive index n(x, y) in the body is continuous. The continuity of the spatial modulation of the refractive index n(x, y) in the body typically exists over a contiguous area B of the body surface, for the diameter D of which, defined as the supremum of the metric distance d(x, y) between two arbitrary points x, y arranged in the area of the body surface, with D:=sup{d(x, y): x, y ? B}, the following applies: D?1 mm, preferably D?10 mm, particularly preferably D?20 mm.

Abstract: A light guide for guiding light for an HMD includes at least one input coupling structure and at least one output coupling structure. The output coupling structure can be oriented such that for all the rays that are coupled out by the output coupling structure and for which the wave vector k has a negative ratio ky/kxz after they have been coupled out, the wave vector k in the light guide has a ratio of ky/kxz of greater than ?0.2, and/or that for all the rays that are coupled out by the output coupling structure and for which the wave vector k has a positive ratio ky/kxz after they have been coupled out, the wave vector k in the light guide has a ratio of ky/kxz of less than +0.2.

Abstract: An optical transmission assembly for transmitting a source image includes a waveguide assembly, an incoupling assembly for coupling light emitted from the source image into the waveguide assembly, and an outcoupling assembly for coupling the light guided in the waveguide assembly out of the waveguide assembly. The light emitted from the source image and coupled into the waveguide assembly can be propagated between the incoupling assembly and the outcoupling assembly in the waveguide assembly by means of a total reflection. The incoupling assembly has at least one diffractive incoupling grating which is inclined by an angle (?) ranging from 20° to 60° relative to a normal of a boundary surface of the waveguide assembly, and/or the outcoupling assembly has at least one diffractive outcoupling grating which is inclined by an angle (?) ranging from 20° to 60° relative to a normal of a boundary surface of the waveguide assembly.

Abstract: A microscope, in particular according to any of the preceding claims, consisting of an illuminating device, comprising an illumination light source and an illumination beam path for illuminating the specimen with a light sheet, a detection device for detecting light emitted by the specimen, and an imaging optical unit, which images the specimen via an imaging objective in an imaging beam path at least partly onto the detection device, wherein the light sheet is essentially planar at the focus of the imaging objective or in a defined plane in proximity of the geometrical focus of the imaging objective, and wherein the imaging objective has an optical axis, which intersects the plane of the light sheet at an angle that is different from zero, preferably perpendicularly, wherein an amplitude and/or phase filter is provided in the illumination beam path, said filter acting as a sine spatial filter in that it limits the illumination light in at least one spatial direction by filtering the spatial frequencies that

Abstract: An object is illuminated sequentially using at least two illumination geometries. An intensity image of the object is captured for each one of the at least two illumination geometries. The intensity images are combined for producing a results image. Combining is carried out in such a way that the results image satisfies a predetermined optimization criterion. By way of example, the optimization criterion may relate to an image contrast, an edge steepness or an image sharpness. Optimization may be carried out with a spatial resolution.

Abstract: An optical system for transmitting a source image is provided. Light having a field angle spectrum emanates from the source image. The optical system includes an optical waveguide arrangement, in which light can propagate by total internal reflection. The optical system also includes a diffractive optical input coupling arrangement for coupling the light emanating from the source image into the optical waveguide arrangement. The optical system further includes a diffractive optical output coupling arrangement for coupling the light that has propagated in the optical waveguide arrangement out from the optical waveguide arrangement. The disclosure also provides related methods.

Abstract: An optical device comprises a light source and a detector, and also a sample holder, which is configured to fix an object in the optical path of light. A scanning optical unit is configured, for a multiplicity of scanning positions, in each case selectively to direct light incident from different angular ranges from the object onto the detector. On the basis of a three-dimensional light field represented by corresponding measurement data of the multiplicity of scanning positions, a spatially resolved imaging of the object is generated, said imaging comprising at least two images from different object planes of the object.

Abstract: A microscopical imaging system for the widefield microscopical imaging of a sample. The imaging system includes a ray path with an objective, a tube lens system arranged behind the objective as seen from the sample, and a relay optical system with an objective-side component and an image-side component. The objective-side component includes at least one first objective-side lens group and a second objective-side lens group. The image-side component includes at least one first image-side lens group and a second image-side lens group. The relay optical system transfers an image of the exit pupil of the objective to a pupil plane between the objective-side component and the image-side component. The relay optical system transfers an image of the sample from an intermediate image plane to an image plane. The imaging system includes an adaptive optical element that is arranged at the pupil plane between the objective-side component and the image-side component.

Abstract: The invention relates to a device for optical examination of a specimen with a cryo-immersion objective, having a stative, to which the cryo-immersion objective is fixed, wherein the cryo-immersion objective has a plurality of optical components, in particular lenses, and wherein the cryo-immersion objective has an optical front component which is in contact during operation with a coolable immersion liquid, having a specimen carrier for a specimen to be examined, having means for providing a cooled immersion liquid between the optical front component and the specimen to be examined on or against the specimen carrier. The device is characterized in that insulating means are present for interrupting a heat transition between the stative and the optical front component.

Abstract: An arrangement for microscopy, having an illumination optical unit with an illumination objective for illuminating a specimen situated on a specimen carrier in a specimen region of a specimen plane via an illumination beam path. An optical axis of the illumination objective lies in a plane which includes an illumination angle that differs from zero with the normal of a specimen plane, in respect of which the specimen carrier is aligned, and the illumination is implemented in the plane. Further, a detection optical unit with a detection objective is located in a detection beam path. The optical axis of the detection objective includes a detection angle that differs from zero with the normal of the specimen plane. The illumination objective and/or the detection objective comprises an illumination correction element arranged in the beam path and/or a detection correction element.

Abstract: An optical system for transmitting a source image is provided. Light having a field angle spectrum emanates from the source image. The optical system includes an optical waveguide arrangement, in which light can propagate by total internal reflection. The optical system also includes a diffractive optical input coupling arrangement for coupling the light emanating from the source image into the optical waveguide arrangement. The optical system further includes a diffractive optical output coupling arrangement for coupling the light that has propagated in the optical waveguide arrangement out from the optical waveguide arrangement. The disclosure also provides related methods.