Patents by Inventor Wolfgang Staehle

Wolfgang Staehle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzyl Piperidine Compounds as Lysophosphatidic Acid (LPA) Receptor Antagonist
    Publication number: 20150011557
    Abstract: The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 8, 2015
    Applicant: Merck Patent GmbH
    Inventors: Kai Schiemann, Wolfgang Staehle, Michael Busch, Dirk Wienke, Oliver Poeschke, Christa Burger
  • N-(benzimimdazol-2-yl)-cyclopropane carboxamides as lysophosphatidic acid antagonists
    Patent number: 8912202
    Abstract: The invention provides novel substituted cyclopropane carboxamide compounds according to Formula (I), their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
    Type: Grant
    Filed: July 7, 2012
    Date of Patent: December 16, 2014
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, Melanie Schultz, Kai Schiemann
  • PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS
    Publication number: 20140350046
    Abstract: The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
    Type: Application
    Filed: August 6, 2014
    Publication date: November 27, 2014
    Applicant: Merck Patent GmbH
    Inventors: Kai SCHIEMANN, Wolfgang STAEHLE, SR., Dirk WIENKE
  • PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS
    Publication number: 20140343075
    Abstract: The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: July 30, 2014
    Publication date: November 20, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Kai SCHIEMANN, Melanie SCHULTZ, Wolfgang STAEHLE
  • Pyrazolopyridinone derivatives as LPA receptor antagonists
    Patent number: 8859775
    Abstract: The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: October 14, 2014
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Wolfgang Staehle, Dirk Wienke
  • Azaheterocyclic compounds as kinase inhibitors
    Patent number: 8859581
    Abstract: The invention relates to compounds of the formula (I), to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumors and/or diseases in the development or course of which kinases are involved.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: October 14, 2014
    Assignee: Merck Patent GmbH
    Inventors: Timo Heinrich, Andree Blaukat, Wolfgang Staehle, Hartmut Greiner, Maria Kordowicz
  • Heterocyclic compounds as autotaxin inhibitors
    Patent number: 8841324
    Abstract: Compounds of the formula (I), in which Het, R, X, Y, R1 and p have the meanings indicated in claim 1, are autotaxin inhibitors and can be employed for the treatment of tumors.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: September 23, 2014
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, Kai Schiemann, Melanie Schultz
  • Piperidine and piperazine derivatives as autotaxin inhibitors
    Patent number: 8822476
    Abstract: The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: September 2, 2014
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle
  • N-(Benzimimdazol-2-yl)-Cyclopropane Carboxamides as Lysophosphatidic Acid Antagonists
    Publication number: 20140228378
    Abstract: The invention provides novel substituted cyclopropane carboxamide compounds according to Formula (I), their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.
    Type: Application
    Filed: July 7, 2012
    Publication date: August 14, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Melanie Schultz, Kai Schiemann
  • Thiazole derivatives
    Publication number: 20140148457
    Abstract: Compounds of the formula I in which R, R1, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKK? and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.
    Type: Application
    Filed: April 12, 2012
    Publication date: May 29, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Srinivasa R. Karra, Wolfgang Staehle, Eike Staub, Margarita Wucherer-Plietker
  • Thiazole derivatives
    Patent number: 8557824
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, K, G, E and W
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: October 15, 2013
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Andree Blaukat, Ingo Kober, Wolfgang Staehle
  • Sulfoxide derivatives for the treatment of tumors
    Patent number: 8552001
    Abstract: Sulfoxide derivatives of the formula Ia to Im as described, and pharmaceutically usable salts, solvates, enantiomers, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for the treatment of tumors.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: October 8, 2013
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle
  • 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer
    Patent number: 8530650
    Abstract: The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: September 10, 2013
    Assignee: MERCK PATENT GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle, Ingo Kober, Dirk Wienke, Mireille Krier
  • Autotaxin inhibitors
    Patent number: 8497283
    Abstract: The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 30, 2013
    Assignee: Merck Patent GmbH
    Inventors: Melanie Schultz, Kai Schiemann, Jr., Wolfgang Staehle
  • PYRAZOLOPYRIDINONE DERIVATIVES AS LPA RECEPTOR ANTAGONISTS
    Publication number: 20130165478
    Abstract: The present invention relates to novel pyrazolopyridinone derivatives according to formula (I) and a process of manufacturing thereof. These pyrazolopyridinone derivatives can be used as LPA receptor antagonists for the treatment of various herein disclosed diseases.
    Type: Application
    Filed: August 5, 2011
    Publication date: June 27, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Kai Schiemann, Wolfgang Staehle, Dirk Wienke
  • AUTOTAXIN INHIBITORS
    Publication number: 20130023556
    Abstract: The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 24, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Melanie SCHULTZ, Kai Schiemann, JR., Wolfgang Staehle
  • BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS
    Publication number: 20130012505
    Abstract: The present invention relates to benzonaphthyridinamines of the formula (I) as autotaxin inhibitors and to the use thereof in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in which the inhibition, regulation and/or modulation of phosphodiesterase or lysophospholipase autotaxin plays a role, in particular of various types of cancer and autoimmune and inflammatory diseases.
    Type: Application
    Filed: February 28, 2011
    Publication date: January 10, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Wolfgang Staehle, Melanie Schultz, Kai Schiemann
  • Autotaxin inhibitors
    Patent number: 8329907
    Abstract: The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: December 11, 2012
    Assignee: Merck Patent GmbH
    Inventors: Melanie Schultz, Kai Schiemann, Wolfgang Staehle
  • 1,3-BENZOXAZOLYL DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20120220611
    Abstract: Compounds of the formula I, the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases that are caused, mediated and/or propagated by angiogenesis. Compounds of the formula I are effective inhibitors of tyrosine kinases, in particular TIE-2 and VEGFR, and of Raf kinases.
    Type: Application
    Filed: May 8, 2012
    Publication date: August 30, 2012
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang STÄHLE, Alfred JONCZYK, Wilfried RAUTENBERG
  • 1,3-benzoxazolyl derivatives as kinase inhibitors
    Patent number: 8242128
    Abstract: The invention relates to compounds of formula 1, the production and use thereof as a medicament for the treatment of diseases, particularly tumours and/or diseases caused, mediated or propagated by angiogenesis. The compounds of formula 1 are effective inhibitors of tyrosin kinases, particularly TIE-2 and VEGFR, and Raf-kinases.
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: August 14, 2012
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Stähle, Alfred Jonczyk, Wilfried Rautenberg