Patents by Inventor Wolfgang Staehle

Wolfgang Staehle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SULFOXIDE DERIVATIVES FOR THE TREATMENT OF TUMORS
    Publication number: 20120202827
    Abstract: Sulfoxide derivatives of the formula Ia to Im as described, and pharmaceutically usable salts, solvates, enantiomers, tautomers and stereoisomers thereof, including mixtures thereof in all ratios, for the treatment of tumours.
    Type: Application
    Filed: September 14, 2010
    Publication date: August 9, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFUNG
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle
  • METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS
    Publication number: 20120130147
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: January 25, 2012
    Publication date: May 24, 2012
    Inventors: Dirk FINSINGER, David Bruge, Hans-Peter Buchstaller, Ulrich Emde, Kai Schiemann, Wolfgang Staehle, Christiane Amendt, Nina Heiss, Frank Zenke
  • HETEROCYCLIC COMPOUNDS AS AUTOTAXIN INHIBITORS
    Publication number: 20120115852
    Abstract: Compounds of the formula (I), in which R, R1, R2, X, X1, Y, Y1, Q, E, n1 and n2 have the meanings indicated in claim 1, are autotaxin inhibitors and can be employed for the treatment of tumours.
    Type: Application
    Filed: June 17, 2010
    Publication date: May 10, 2012
    Applicant: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Melanie Schultz, Kai Schiemann, Wolfgang Staehle
  • PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS
    Publication number: 20120059016
    Abstract: The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: March 3, 2010
    Publication date: March 8, 2012
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle
  • Tetrahydroquinoline derivatives
    Patent number: 8110583
    Abstract: Compounds of the formula I, in which s, k, I, W, R1, R2, R3, and U have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: February 7, 2012
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, David Bruge, Kai Schiemann, Dirk Finsinger, Hans-Peter Buchstaller, Frank Zenke, Christiane Amendt
  • AUTOTAXIN INHIBITORS
    Publication number: 20120015976
    Abstract: The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: March 9, 2010
    Publication date: January 19, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG
    Inventors: Melanie Schultz, Kai Schiemann, Wolfgang Staehle
  • HETEROCYCLIC COMPOUNDS AS AUTOTAXIN INHIBITORS
    Publication number: 20120015959
    Abstract: Compounds of the formula (I), in which Het, R, X, Y, R1 and p have the meanings indicated in claim 1, are autotaxin inhibitors and can be employed for the treatment of tumours.
    Type: Application
    Filed: March 3, 2010
    Publication date: January 19, 2012
    Inventors: Wolfgang Staehle, Kai Schiemann, Melanie Schultz
  • N,N?-diphenylurea derivatives which are suitable as kinase inhibitors
    Patent number: 8097727
    Abstract: Compounds of the formula (I), in which R1a-R1e, R2a, R2b, R3 and R5 have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumors.
    Type: Grant
    Filed: October 4, 2005
    Date of Patent: January 17, 2012
    Assignee: Merck patent GmbH
    Inventors: Wolfgang Staehle, Guenter Hoelzemann, Wilfried Rautenberg
  • 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER
    Publication number: 20110237583
    Abstract: The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: November 3, 2009
    Publication date: September 29, 2011
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle, Ingo Kober, Dirk Wienke, Mireille Krier
  • BENZONAPHTYRIDINE COMPOUNDS AS INHIBITORS OF AUTOTAXIN
    Publication number: 20110230471
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, R5, D, Z, X, Y, m and p have the meanings indicated in Claim 1, can and be employed for the treatment of tumours.
    Type: Application
    Filed: November 5, 2009
    Publication date: September 22, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Wolfgang Staehle, Ingo Kober, Kai Schiemann, Melanie Schultz, Dirk Wienke
  • Tetrahydroquinolines
    Patent number: 7915416
    Abstract: Disclosed are compounds of formula (I), wherein W, R, R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in claim 1. Said compounds can be used for the treatment of tumors, among other things.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: March 29, 2011
    Assignee: Merck Patent GmbH
    Inventors: Kai Schiemann, David Bruge, Hans-Peter Buchstaller, Dirk Finsinger, Wolfgang Staehle, Christiane Amendt, Ulrich Emde, Frank Zenke
  • THIAZOLE DERIVATIVES
    Publication number: 20100240676
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, K, G, E and W
    Type: Application
    Filed: September 19, 2008
    Publication date: September 23, 2010
    Applicant: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Kai Schiemann, Melanie Schultz, Andree Blaukat, Ingo Kober, Wolfgang Staehle
  • SULFAMATOBENZOTHIOPHENE DERIVATIVES
    Publication number: 20100168217
    Abstract: The invention relates to novel compound of the general formula (I), in which R has the meanings indicated in claim 1, to the preparation thereof and to the use thereof as medicaments. The compounds (I) are inhibitors of steroid sulfatase and are used for the treatment of cancer.
    Type: Application
    Filed: November 13, 2007
    Publication date: July 1, 2010
    Applicant: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, David Bruge, Gerald Scholz, Benoit Rondot, Jean Lafay
  • NOVEL CYCLOBUTYL COMPOUNDS AS KINASE INHIBITORS
    Publication number: 20100160356
    Abstract: The invention relates to compounds of the formula I, to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases in the formation or course of which protein kinases are involved.
    Type: Application
    Filed: March 8, 2007
    Publication date: June 24, 2010
    Inventors: Timo Heinrich, Wolfgang Staehle, Hartmut Greiner, Andree Blaukat
  • Phenylurea derivatives as inhibitors of tyrosine kinases for the treatment of tumour diseases
    Patent number: 7696224
    Abstract: Compounds of the formula (I), in which R1a—R1e, R2a, R2b, R3 and X have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: April 13, 2010
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Staehle, Guenter Hoelzemann, Wilfried Rautenberg
  • Inhibitors of integrin ??
    Patent number: 7632951
    Abstract: Novel biphenyl derivatives of the general formula (I) in which R1, R1?, R1?, R2, R2?, R3 and n are as defined in claim 1, their stereoisomers and their physiologically acceptable salts or solvates are novel integrin inhibitors which preferentially inhibit the ?v?6 integrin receptor. The novel compounds can be used, in particular, as medicaments.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: December 15, 2009
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Oliver Schadt, Alfred Jonczyk, Wolfgang Staehle, Simon Goodman
  • SUBSTITUTED TETRAHYDROPYRROLOQUINOLINE DERIVATIVES AS KINASE MODULATORS, ESPECIALLY OF TYROSINE AND RAF KINASES
    Publication number: 20090306122
    Abstract: Compound of the formula (I), in which X, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: February 13, 2006
    Publication date: December 10, 2009
    Inventors: Wolfgang Staehle, Timo Heinrich, Maria Kordowicz, Andree Blaukat, Lars Thore Burgdorf
  • SULFAMATOBENZOTHIOPHENE DERIVATIVES
    Publication number: 20090286863
    Abstract: The invention relates to novel compound of the general formula (I), in which R has the meanings indicated in Claim 1, to the preparation thereof and to the use thereof as medicaments. The compounds (I) are inhibitors of steroid sulfatase and are used for the treatment of cancer.
    Type: Application
    Filed: June 5, 2007
    Publication date: November 19, 2009
    Inventors: David Bruge, Wolfgang Staehle, Gerald Scholz, Benoit Rondot, Jean Lafay
  • Pyridopyrimidinones
    Patent number: 7547695
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and X? have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumors.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: June 16, 2009
    Assignee: Merck Patent GmbH
    Inventors: Guenter Hoelzemann, Helene Crassier, Karl-August Ackermann, Wolfgang Staehle, Alfred Jonczyk, Wilfried Rautenberg, Francesc Mitjans, Elisabet Rosell-Vives, Jaume Adan, Marta Soler Riera
  • INDANES
    Publication number: 20090118267
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: February 13, 2006
    Publication date: May 7, 2009
    Inventors: Dirk Finsinger, David Bruge, Hans-Peter Buchstaller, Ulrich Emde, Kai Schiemann, Wolfgang Staehle, Christiane Amendt, Nina Heiss, Frank Zenke