Abstract: The present invention pertains to novel immunogenic peptide sequences that can be used as vaccines in the treatment of cancer diseases such as brain cancers and specifically glioma. The cancer vaccines of the invention are designed based on the K27M mutated variant of the human Histone 3. Provided are further fusion proteins comprising the sequences of the cancer vaccines, nucleic acids encoding such vaccines, such as RNA vaccines, and vectors and host cells comprising these sequences. Furthermore the invention pertains to T cells and T cell receptors binding the cancer vaccines of the invention, preferably when presented by the human Major Histocompatibility Complex (MHC). The peptide immunogens of the invention elicit a HLA restricted immune response and therefore are of use in the treatment of cancer diseases, in particular glioma. Further aspects of the invention pertain to pharmaceutical compositions as well as diagnostic methods based on the immunogenic capacity of the disclosed peptides.

Abstract: Among other things, a method is disclosed which comprises the following: acquiring at least one set of acceleration data indicative of a progression of measured acceleration values; determining at least one set of evaluation data at least partially based on the acquired acceleration data, wherein determining the evaluation data comprises determining whether one or more characteristic actions have been performed by a user, and if so, performing the following: storing an action data representing the one or more actions that is included in the determined evaluation data or is at least a part of the determined evaluation data; and outputting or causing the output of the determined evaluation data. A device for executing and/or controlling this method, a system with one or more devices for executing and/or controlling this method and a computer program for executing and/or controlling this method by a processor are further disclosed.

Abstract: A method for setting a time of a release of a cleaning agent during a cleaning cycle in a household appliance includes obtaining an evolution over time of a local parameter inside the appliance, the local parameter comprising an acceleration induced by the cycle or a temperature inside the appliance; obtaining reference patterns of evolutions of the local parameter during a cycle comprising different cleaning steps including a step adapted for releasing the cleaning agent at a predetermined adapted time; comparing the evolution of the local parameter to the reference patterns and identifying a cleaning step within the cycle when a similarity between a reference pattern and the evolution is above a predetermined threshold, and setting the release of the agent at the predetermined adapted time within the identified cleaning step when the identified step corresponds to a step adapted for releasing the agent.

Abstract: A method for fragrancing and/or deodorizing a cleaning appliance is disclosed. The method involves capturing first information or obtaining captured first information indicative of an odor load in the interior of the cleaning appliance, producing fragrancing and/or deodorizing information based at least in part on the captured or obtained first information or outputting the captured first information in order to produce fragrancing and/or deodorizing information of this type, and initiating fragrancing and/or deodorization by employing at least one actuator for releasing a fragrancing and/or deodorizing agent based on the fragrancing and/or deodorizing information produced. A corresponding dosing device, a device for carrying out and/or controlling the method, and a system with one or more devices for carrying out and/or controlling the method are also disclosed.

Abstract: The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO II° and III°, as well as IV° (glioblastoma), in a subject.

Abstract: The invention relates to a device (50; 50a to 50c) for determining the weight of a capsule (10) arranged in a receptacle (26) of a capsule holder (25) of an incrementally rotated conveyor wheel (21), comprising a transfer device (52; 52a to 52c) for transferring at least one capsule (10) from the capsule holder (25) into a capsule receiver (55) having a plurality of receptacles (54) for respectively one capsule (10), and back again, wherein the capsule receptacle (55) has a movable arrangement in a plane parallel to the conveyor plane of the conveyor wheel (21).

Abstract: The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO I? and 111°, as well as IV0 (glioblastoma), in a subject.

Abstract: The present invention concerns a pharmaceutical composition where a checkpoint inhibitor is combined with an oncolytic virus and the use of said combination for the treatment of cancer.

Abstract: Among other things, a method is disclosed which includes the following: acquiring at least one set of acceleration data indicative of a progression of measured acceleration values; determining status data indicative of a process step within a cleaning program performed by a dishwasher; outputting or causing the output of the determined status data. Further revealed is a device for executing and/or controlling this method, a system with one or more devices for executing and/or controlling this method and a computer program for executing and/or controlling this method by employing a processor.

Abstract: Among other things, a method is disclosed which comprises the following: acquiring at least one set of acceleration data indicative of a progression of measured acceleration values; determining at least one set of evaluation data at least partially based on the acquired acceleration data, wherein determining the evaluation data comprises determining whether one or more characteristic actions have been performed by a user, and if so, performing the following: storing an action data representing the one or more actions that is included in the determined evaluation data or is at least a part of the determined evaluation data; and outputting or causing the output of the determined evaluation data. A device for executing and/or controlling this method, a system with one or more devices for executing and/or controlling this method and a computer program for executing and/or controlling this method by a processor are further disclosed.

Abstract: The present invention concerns a pharmaceutical composition where a checkpoint inhibitor is combined with an oncolytic virus and the use of said combination for the treatment of cancer.

Abstract: Described is a pharmaceutical composition comprising (a) a parvovirus and (b) bevacizumab and the use of said composition for treatment of cancer, e.g., a solid tumor.

Abstract: The invention relates to a device for filling containers with filling material in powder form, comprising: at least one metering wheel (29); a metering chamber (28a, 28b); at least one container (27) for discharging into the metering chamber (28a, 28b) a filling material (21) to be metered; at least one filter (36) which is mounted on the metering chamber (28a, 28b), the filter (36) being non-permeable to the filling material (21) and permeable to a gaseous medium; at least one feed (46) for the gaseous medium, to influence the filling material (21) to be metered in the metering chamber (28a, 28b) by means of the gaseous medium via the filter (36), at least one transport means (43) being provided to displace the filter (36) such that a new region of the filter (36) reaches the underside of the metering chamber (28a, 28b).

Abstract: The invention relates to a device (50; 50a to 50c) for determining the weight of a capsule (10) arranged in a receptacle (26) of a capsule holder (25) of an incrementally rotated conveyor wheel (21), comprising a transfer device (52; 52a to 52c) for transferring at least one capsule (10) from the capsule holder (25) into a capsule receiver (55) having a plurality of receptacles (54) for respectively one capsule (10), and back again, wherein the capsule receptacle (55) has a movable arrangement in a plane parallel to the conveyor plane of the conveyor wheel (21).

Abstract: A method for setting a time of a release of a cleaning agent during a cleaning cycle in a household appliance includes obtaining an evolution over time of a local parameter inside the appliance, the local parameter comprising an acceleration induced by the cycle or a temperature inside the appliance; obtaining reference patterns of evolutions of the local parameter during a cycle comprising different cleaning steps including a step adapted for releasing the cleaning agent at a predetermined adapted time; comparing the evolution of the local parameter to the reference patterns and identifying a cleaning step within the cycle when a similarity between a reference pattern and the evolution is above a predetermined threshold, and setting the release of the agent at the predetermined adapted time within the identified cleaning step when the identified step corresponds to a step adapted for releasing the agent.

Abstract: The present invention pertains to novel immunogenic peptide sequences that can be used as vaccines in the treatment of cancer diseases such as brain cancers and specifically glioma. The cancer vaccines of the invention are designed based on the K27M mutated variant of the human Histone 3. Provided are further fusion proteins comprising the sequences of the cancer vaccines, nucleic acids encoding such vaccines, such as RNA vaccines, and vectors and host cells comprising these sequences. Furthermore the invention pertains to T cells and T cell receptors binding the cancer vaccines of the invention, preferably when presented by the human Major Histocompatibility Complex (MHC). The peptide immunogens of the invention elicit a HLA restricted immune response and therefore are of use in the treatment of cancer diseases, in particular glioma. Further aspects of the invention pertain to pharmaceutical compositions as well as diagnostic methods based on the immunogenic capacity of the disclosed peptides.

Abstract: Described is a pharmaceutical composition comprising (a) a parvovirus and (b) bevacizumab and the use of said composition for treatment of cancer, e.g., a solid tumor.

Abstract: The invention relates to a device for filling containers with filling material in powder form, comprising: at least one metering wheel (29); a metering chamber (28a, 28b); at least one container (27) for discharging into the metering chamber (28a, 28b) a filling material (21) to be metered; at least one filter (36) which is mounted on the metering chamber (28a, 28b), the filter (36) being non-permeable to the filling material (21) and permeable to a gaseous medium; at least one feed (46) for the gaseous medium, to influence the filling material (21) to be metered in the metering chamber (28a, 28b) by means of the gaseous medium via the filter (36), at least one transport means (43) being provided to displace the filter (36) such that a new region of the filter (36) reaches the underside of the metering chamber (28a, 28b).

Abstract: A method for fragrancing and/or deodorizing a cleaning appliance is disclosed. The method involves capturing first information or obtaining captured first information indicative of an odor load in the interior of the cleaning appliance, producing fragrancing and/or deodorizing information based at least in part on the captured or obtained first information or outputting the captured first information in order to produce fragrancing and/or deodorizing information of this type, and initiating fragrancing and/or deodorization by employing at least one actuator for releasing a fragrancing and/or deodorizing agent based on the fragrancing and/or deodorizing information produced. A corresponding dosing device, a device for carrying out and/or controlling the method, and a system with one or more devices for carrying out and/or controlling the method are also disclosed.

Abstract: The present invention concerns a pharmaceutical composition where a checkpoint inhibitor is combined with an oncolytic virus and the use of said combination for the treatment of cancer.