Patents by Inventor Wolfgang Wostl

Wolfgang Wostl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRONIC AND TETRAMIC ACIDS
    Publication number: 20080132562
    Abstract: This invention relates to new tetronic and tetramic acid derivatives with beta-secretase inhibitory activity of formula I: wherein R1, R2, R3, R4, R5, R5?, R6 and R6? are as defined hereinabove, to processes for their preparation, compositions containing said tetronic and tetramic acid derivatives and their use in the treatment and prevention of diseases modulated by an inhibitor of ?-secretase, such as Alzheimer's disease.
    Type: Application
    Filed: January 31, 2008
    Publication date: June 5, 2008
    Inventors: Thierry Godel, Hans Hilpert, Roland Humm, Mark Rogers-Evans, Didier Rombach, Christopher Martin Stahl, Peter Weiss, Wolfgang Wostl
  • 4-OXO-2,3,4,5-TETRAHYDRO-BENZO[b][1,4]DIAZEPINE DERIVATIVES
    Publication number: 20080103133
    Abstract: The invention relates to 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepines of formula I wherein R1, R2, R3 and R4 are as defined in the description and claims, which are ?-secretase inhibitors and which may be useful in the treatment of Alzheimer's disease.
    Type: Application
    Filed: September 14, 2007
    Publication date: May 1, 2008
    Inventors: Alexander Flohr, Roland Jakob-Roetne, Wolfgang Wostl
  • Malonamide derivatives
    Publication number: 20070225273
    Abstract: The invention relates to malonamide derivatives of formula wherein A1, A2, R1, R2, R3, and R4 are as defined herein and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof for the treatment of Alzheimer's disease.
    Type: Application
    Filed: March 22, 2007
    Publication date: September 27, 2007
    Inventors: Alexander Flohr, Roland Jakob-Roetne, Wolfgang Wostl
  • Benzyloxy derivatives as MAOB inhibitors
    Patent number: 7253318
    Abstract: The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are as defined in the specification. The compounds are selective monoamine oxidase ? inhibitors and are useful for the treatment and prevention of Alzheimer's disease and senile dementia, as well as other CNS disorders. The invention also relates to processes for preparing such compounds and pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: August 7, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7235581
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: June 26, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • Bicyclic compounds
    Publication number: 20070117791
    Abstract: The present invention relates to methods for making and using novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X?, Y and Y? are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
    Type: Application
    Filed: January 12, 2007
    Publication date: May 24, 2007
    Inventors: Synese Jolidon, Rosa Rodriguez Sarmiento, Andrew Thomas, Wolfgang Wostl, Rene Wyler
  • Malonamide derivatives
    Patent number: 7211573
    Abstract: The invention relates to compounds of the formula I wherein R, R1, R2, R3, X, and n are defined in the specification. The invention also provides pharmaceutically suitable acid addition salts thereof and all forms of optically pure enantiomers, recemates or diastereomers and diastereomeric mixtures thereof. Compounds of the invention are useful for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: November 30, 2005
    Date of Patent: May 1, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Flohr, Roland Jakob-Roetne, Wolfgang Wostl
  • Fluoro substituted 2-oxo-azepan derivatives
    Publication number: 20070037789
    Abstract: The invention relates to compounds of general formula wherein R1, R2, R3/R3?, R4/R4? and R5/R5? are as defined in the specification and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. The compounds are ?-secretase inhibitors which can be useful in the treatment of Alzheimer's disease or common cancers including, but not limited to, cervical carcinomas and breast carcinomas and malignancies of the hematopoietic system.
    Type: Application
    Filed: August 8, 2006
    Publication date: February 15, 2007
    Inventors: Alexander Flohr, Guido Galley, Roland Jakob-Roetne, Eric Kitas, Wolfgang Wostl
  • Bicyclic compounds
    Patent number: 7173023
    Abstract: The present invention relates to novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X?, Y and Y? are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: February 6, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • Carbamic acid alkyl ester derivatives
    Patent number: 7166587
    Abstract: The present invention provides compounds of the general formula wherein R4 is one of the following groups ?and R1, R2, R3, R7, R8, and R9 are as defined in the specification and pharmaceutically acceptable salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. The compounds are useful for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: January 23, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Flohr, Guido Galley, Roland Jakob-Roetne, Eric Argirios Kitas, Jens-Uwe Peters, Wolfgang Wostl
  • Malonamide derivatives
    Patent number: 7160875
    Abstract: The invention relates to malonamide derivatives of formula wherein each of the variables are as defined herein and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates and diastereomeric mixtures thereof. These compounds are ?-secretase inhibitors and may be used for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: January 9, 2007
    Assignee: Hoffmann-La Rache Inc.
    Inventors: Alexander Flohr, Guido Galley, Roland Jakob-Roetne, Eric Argirios Kitas, Jens-Uwe Peters, Wolfgang Wostl
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7151111
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a monoamine oxidase B inhibitor, in particular Alzheimer's disease and senile dementia.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: December 19, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • Process for the preparation of enantiopure pyrrolidin-2-one derivatives
    Patent number: 7148362
    Abstract: The present invention relates to a process for the preparation of enantiopure intermediates useful in the synthesis of valuable pharmaceutically active compounds, e.g. MAOB inhibitors, and to novel intermediates of formulae I and II wherein R21, R22, R23 and R24 are as defined in the description and claims.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: December 12, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Daniela Krummenacher, Beat Wirz, Wolfgang Wostl
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7122562
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: October 17, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
    Publication number: 20060211868
    Abstract: The invention relates to a method for preparing enantiomerically pure 4-pyrrolidinophenylbenzyl ether derivatives of formula I: wherein R1, R21, R22, R23, R24 and n are as defined in the description and claims and to intermediates useful in the method of the invention as well as salts thereof.
    Type: Application
    Filed: March 8, 2006
    Publication date: September 21, 2006
    Inventors: Stefan Hildbrand, Bruno Lohri, Wolfgang Wostl
  • Malonamide derivatives
    Publication number: 20060122168
    Abstract: The invention relates to compounds of the formula I wherein R, R1, R2, R3, X, and n are defined in the specification. The invention also provides pharmaceutically suitable acid addition salts thereof and all forms of optically pure enantiomers, recemates or diastereomers and diastereomeric mixtures thereof. Compounds of the invention are useful for the treatment of Alzheimer's disease.
    Type: Application
    Filed: November 30, 2005
    Publication date: June 8, 2006
    Inventors: Alexander Flohr, Roland Jakob-Roetne, Wolfgang Wostl
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Publication number: 20060122235
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Application
    Filed: January 5, 2006
    Publication date: June 8, 2006
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Rodriguez-Sarmiento, Andrew Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • 4-Pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7037935
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: May 2, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • Benzyloxy derivatives
    Publication number: 20060025599
    Abstract: The present invention relates to compounds of formula I wherein R1 and R2 are as defined in the specification and to pharmaceutically acceptable salts thereof for the treatment of diseases, which are mediated by monoamine oxidase B inhibitors, for example Alzheimer's disease and senile dementia.
    Type: Application
    Filed: July 27, 2005
    Publication date: February 2, 2006
    Inventors: Rosa Rodriguez-Sarmiento, Wolfgang Wostl, Rene Wyler
  • Benzyloxy derivatives as MAOB inhibitors
    Publication number: 20050288367
    Abstract: The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are as defined in the specification. The compounds are selective monoamine oxidase ? inhibitors and are useful for the treatment and prevention of Alzheimer's disease and senile dementia, as well as other CNS disorders. The invention also relates to processes for preparing such compounds and pharmaceutical compositions containing them.
    Type: Application
    Filed: June 20, 2005
    Publication date: December 29, 2005
    Inventors: Synese Jolidon, Rosa Rodriguez-Sarmiento, Andrew Thomas, Wolfgang Wostl, Rene Wyler