Patents by Inventor Wolfgang Wostl

Wolfgang Wostl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidine derivatives
    Patent number: 6197959
    Abstract: Compounds of formula (I) wherein R1 and R2 are as defined in the description and claims and pharmaceutically acceptable salts thereof, are useful for the treating diseases associated with restenosis, glaucoma, cardiac infarct, high blood pressure and end organ damage, for example, cardiac insufficiency and kidney insufficiency.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: March 6, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Volker Breu, Daniel Bur, Hans-Peter Märki, Eric Vieira, Wolfgang Wostl
  • Piperidine derivative having renin inhibiting activity
    Patent number: 6150526
    Abstract: Piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: November 21, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Volker Breu, Daniel Bur, Walter Fischli, Rolf Guller, Georges Hirth, Hans-Peter Marki, Marcel Muller, Christian Oefner, Heinz Stadler, Eric Vieira, Maurice Wilhelm, Wolfgang Wostl
  • Piperidine derivatives having renin inhibiting activity
    Patent number: 6051712
    Abstract: Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: April 18, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alfred Binggeli, Volker Breu, Daniel Bur, Walter Fischli, Rolf Guller, Georges Hirth, Hans-Peter Marki, Marcel Muller, Christian Oefner, Heinz Stadler, Eric Vieira, Maurice Wilhelm, Wolfgang Wostl
  • Amino acid derivatives having renin inhibiting activity
    Patent number: 5688946
    Abstract: The compounds of the formula ##STR1## in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: November 18, 1997
    Assignee: Hoffmann La Roche Inc.
    Inventors: Quirico Branca, Werner Neidhart, Henri Ramuz, Heinz Stadler, Wolfgang Wostl
  • Amino acid derivatives having renin inhibiting activity
    Patent number: 5393875
    Abstract: The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the significance given in claim 1,in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharamaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency. They can be manufactured according to various methods which are known per se.
    Type: Grant
    Filed: August 3, 1993
    Date of Patent: February 28, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Quirico Branca, Marie-Paule Heitz, Werner Neidhart, Heinz Stadler, Eric Vieira, Wolfgang Wostl
  • Amino acid derivatives
    Patent number: 5389616
    Abstract: The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as set forth above, are described.The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency.
    Type: Grant
    Filed: July 29, 1993
    Date of Patent: February 14, 1995
    Assignee: Hoffman-LaRoche Inc.
    Inventors: Quirico Branca, Werner Neidhart, Jenri Ramuz, Henri Ramuz, Heinz Stadler, Wolfgang Wostl
  • Amino acid derivatives useful as renin inhibitors
    Patent number: 5278161
    Abstract: Compounds of the formula ##STR1## wherein A, B, X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as set forth in the specification, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diasteromeric racemates as well as pharmaceutically acceptable salts thereof which inhibit the activity of the natural enzyme renin and are useful in the control or prevention of high blood pressure and cardiac insufficiency are described.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: January 11, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Quirico Branca, Marie-Paule Heitz, Marcel Muller, Werner Neidhart, Stadler Heinz, Eric Vieira, Wolfgang Wostl
  • Amino acid derivatives useful for treating high blood pressure
    Patent number: 5278148
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or methyl, R.sup.2 is ethyl, propyl, isopropyl, imidazol-2-yl, imidazol-4-yl, pyrazol-3-yl, thiazol-4-yl, thien-2-yl, ethoxycarbonyl, t-butylcarbonylmethyl, benzyloxycarbonylmethyl or t-butoxy, R.sup.3 is isobutyl, cyclohexylmethyl or benzyl, R.sup.4 is nitro, amino or a group of the formula --N(R.sup.5)(R.sup.6) and A is one of the groups ##STR2## wherein R.sup.5 and R.sup.6 is alkyl or alkoxyalkyl; or optionally substituted phenyl, phenylalkyl or phenylsulfonylalkyl among others with the proviso that A is not group (b) when R.sup.6 is alkanoyl, alkoxycarbonyl or arylalkoxycarbonyl, the dotted line can be an additional bond, R.sup.7 is phenyl or substituted phenyl and R.sup.8 is hydrogen or organocarbonylalkyl, with the proviso that R.sup.8 is not alkoxycarbonylamino or arylalkoxycarbonylamino when R.sup.7 is phenyl, benzyl or .alpha.
    Type: Grant
    Filed: March 27, 1990
    Date of Patent: January 11, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Quirico Branca, Hans P. Marki, Werner Neidhart, Henri Ramuz, Wolfgang Wostl
  • Amino acid derivatives
    Patent number: 5256645
    Abstract: The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as set forth above, are described.The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency.
    Type: Grant
    Filed: April 22, 1992
    Date of Patent: October 26, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Quirico Branca, Werner Neidhart, Henri Ramuz, Heinz Stadler, Wolfgang Wostl
  • Renin inhibiting compounds
    Patent number: 5250517
    Abstract: Compounds which are amino acid derivatives and have the formula ##STR1## in which R.sup.1 is hydrogen or methyl, R.sup.2 is ethyl, propyl or imidazol-4-yl, R.sup.3 is isobutyl, cyclohexylmethyl or benzyl, and A is defined as herein are useful as renin inhibitors.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: October 5, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Quirico Branca, Albrecht Edenhofer, Eva-Maria Gutknecht, Werner Neidhart, Henri Ramuz, Wolfgang Wostl
  • Process for preparing optically pure (S)-.alpha.-((tert-butylsulfonyl)methyl)hydrocinnamic acid using protease
    Patent number: 5223432
    Abstract: Optically pure (S)-.alpha.-[(tert-butylsulfonyl)methyl]-hydrocinnamic acid of the formula ##STR1## is prepared from racemic (RS)-.alpha.-[(tert-butylsulfonyl)-methyl]hydrocinnamic acid esters of the formula ##STR2## wherein R.sup.1 is C.sub.1-4 -alkyl, by protease-catalyzed selective hydrolysis in emulsion in an aqueous medium at a controlled pH value between about 6.5 and 8.5.
    Type: Grant
    Filed: September 6, 1991
    Date of Patent: June 29, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Beat Wirz, Wolfgang Wostl
  • Amino acid derivatives which have renin inhibiting activity
    Patent number: 5140011
    Abstract: The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the significance given in claim 1, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as pharmaceutically usable salts thereof inhibit the activity of the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations in the control or prevention of high blood pressure and cardiac insufficiency.
    Type: Grant
    Filed: March 29, 1990
    Date of Patent: August 18, 1992
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Quirico Branca, Hans P. Marki, Werner Neidhart, Henri Ramuz, Wolfgang Wostl
  • Amino acid derivatives
    Patent number: 5134123
    Abstract: The compounds of the formula ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as set forth above, are described.The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency.
    Type: Grant
    Filed: March 3, 1989
    Date of Patent: July 28, 1992
    Assignee: Hoffman-La Roche Inc.
    Inventors: Quirico Branca, Werner Neidhart, Henri Ramuz, Heinz Stadler, Wolfgang Wostl