Abstract: Substituted phenylthiohydantoins are provided for use in detecting the presence of tumor cells having androgenic receptors and providing for cytostatic and cytotoxic activity toward such cells. The subject compounds provide for vehicles for specific targeting to the androgenic receptor containing cells of cytostatic and/or cytotoxic agents, heavy or light radioactive or radioopaque atoms, and the like for detection and treatment of cancer cells involving androgenic receptors or blocking androgenic receptors.

Abstract: Chemotherapeutic agents that exhibit cytotoxicity similar to that of daunomycin against cancer cells, but exhibit lessened cytotoxicity against normal, non-transformed cells are disclosed, as are compositions, processes for making and using the same.

Abstract: A method for inducing apoptosis in target cells employs designed enediynes which are triggered to become chemically reactive when bound to target cells. Conversely, a method for inhibiting the induction of apoptosis employs compounds which compete with the above compounds which induce apoptosis, but which are chemically unreactive with respect to the target cells.

Abstract: Chemotherapeutic agents that exhibit cytotoxicity similar to that of daunomycin against cancer cells, but exhibit lessened cytotoxicity against normal, non-transformed cells are disclosed, as are compositions, processes for making and using the same.

Abstract: The invention provides for antinomycin D derivatives and methods of producing antinomycin D derivatives. Such derivatives include isocyanate, thioisocyanate, carboxylic acid, bromide, aldehyde and sulfonic acid derivatives. The invention also provides for actinomycin D derivatives conjugated to target cell binding proteins. Methods are provided to make such conjugates through attachment of the derivatized moiety to a reactive group on a target cell binding protein or on a spacer. The conjugates can be administered to an animal and produce localized cytotoxic effects on target cells.

Abstract: A method and generator for preparing the radioisotope of lead, .sup.212 Pb, whereby .sup.228 Th, in a closed chamber, is allowed to decay to gaseous .sup.220 Rn which is then readily separated from the thorium and other decay products by diffusing the .sup.220 Rn gas into a second chamber, where it decays to .sup.212 Pb which can then be collected from the second chamber. The .sup.228 Th preferably is amorphous, such as thorium stearate. Collection of .sup.212 Pb occurs in a medium of high and open porosity into which the .sup.220 Rn diffuses so that the decay products recoil into the medium. The .sup.212 Pb can be recovered from this medium by dissolving the medium or by reacting it with an antibody-chelating complex solution to entrap it in the antibody-chelating complex.

Abstract: A fabric of a polymer material useful for filtration and other purposes can be treated with a mixture of a solvent for the polymer material in a liquid which is not a solvent for the polymer material and which is more volatile than the solvent for a time and at a temperature sufficient to dissolve some polymer material in the strands. As this occurs the surface tension of the dissolved polymer will cause the dissolved polymer to move to create a continuous, smooth walled, curved surface connecting adjacent strands and extending between such strands.