Patents by Inventor Wolfhard Semmler

Wolfhard Semmler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Near Infrared Imaging Agent
    Publication number: 20100129293
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Application
    Filed: January 26, 2010
    Publication date: May 27, 2010
    Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Kai Licha, Bjórn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Near infrared imaging agent
    Patent number: 7655217
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: February 2, 2010
    Assignee: Institut fur Diagnosikforschung GmbH
    Inventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • In-vivo diagnostic method by near infrared radiation
    Patent number: 7445767
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: November 4, 2008
    Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
    Patent number: 7175953
    Abstract: The description herein includes cyanine dyes and analogs of the vaso-active intestinal peptide. These are useful to provide peptide-dye conjugates for use as contrast media in optical diagnoses.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: February 13, 2007
    Assignee: Institute Fuer Diagnostik Forschung
    Inventors: Kai Licha, Andreas Becker, Wolfhard Semmler, Bertram Wiedenmann, Carsten Hessenius, Rudolf Volkmer-Engert, Jens Schneider-Mergner
  • Near infrared imaging agent
    Publication number: 20060165599
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Application
    Filed: March 22, 2006
    Publication date: July 27, 2006
    Applicant: Institut fur Diagnostikforschung GmbH
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • In-vivo diagnostic method by near infrared radiation
    Publication number: 20060165598
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Application
    Filed: March 22, 2006
    Publication date: July 27, 2006
    Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • In-vivo diagnostic method by means of near infrared radiation
    Patent number: 7025949
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: April 11, 2006
    Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Short-warp peptide dye conjugate as contrast agent for optical diagnostic
    Publication number: 20060036072
    Abstract: The invention relates to compounds for tumor diagnosis that consist of conjugates of dyes with short-chain peptides, which are derived from vaso-active intestinal peptide, somatostatin or neurotensin, the use of these compounds as optical diagnostic agents, and diagnostic agents that contain these compounds.
    Type: Application
    Filed: July 25, 2003
    Publication date: February 16, 2006
    Applicant: Institut fur Diagnostikforschung GmbH
    Inventors: Kai Licha, Andreas Becker, Wolfhard Semmler, Bertram Wiedenmann, Carsten Hessenius, Rudolf Volkmer-Engert, Jens Schneider-Mergner
  • In-vivo diagnostic method by means of near infrared radiation
    Patent number: 6926885
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: August 9, 2005
    Assignees: Institut fur Diagnostikforschung GmbH, Freien Universitat Berlin
    Inventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Near infrared imaging agent
    Publication number: 20050169844
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 4, 2005
    Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Near infrared imaging agent
    Patent number: 6913743
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: July 5, 2005
    Assignee: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • In-vivo diagnostic method by near infrared radiation
    Publication number: 20050106106
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Application
    Filed: December 16, 2004
    Publication date: May 19, 2005
    Applicant: Institut fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Short-chain peptide-dye conjugates as contrast media for optical diagnosis
    Patent number: 6630570
    Abstract: The invention relates to compounds for tumor diagnosis that consist of conjugates of dyes with short-chain peptides, which are derived from vaso-active intestinal peptide, somatostatin or neurotensin, the use of these compounds as optical dignostic agents, and diagnostic agents that contain these compounds.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: October 7, 2003
    Assignee: Insitut für Diagnostikforschung GmbH
    Inventors: Kai Licha, Andreas Becker, Wolfhard Semmler, Bertram Wiedenmann, Carsten Hessenius, Rudolf Volkmer-Engert, Jens Schneider-Mergner
  • Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
    Publication number: 20030185757
    Abstract: The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes.
    Type: Application
    Filed: March 27, 2002
    Publication date: October 2, 2003
    Inventors: Mayk Kresse, Detlev Pfefferer, Ruediger Lawaczeck, Susanne Wagner, Wolfgang Ebert, Volker Elste, Wolfhard Semmler, Matthias Taupitz, Josef Gaida, Anja Herrmann, Monika Ebert, Udo Swiderski
  • Near infrared imaging agent
    Publication number: 20030170179
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Application
    Filed: February 19, 2003
    Publication date: September 11, 2003
    Applicant: Institut fur Diagnostikforschung GMBH an der freien Universita (copy)
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
    Patent number: 6576221
    Abstract: The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes. The nanoparticles according to the invention are characterized in that they consist of an iron-containing core, a primary coat (synthesis polymer), and a secondary coat (targeting polymer) and, optionally, of pharmaceutic adjuvants, pharmaceuticals, and/or adsorption mediators/enhancers.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: June 10, 2003
    Assignees: Institut fur Diagnostikforschung GmbH, Der Freien Universitat Berline
    Inventors: Mayk Kresse, Detlev Pfefferer, Rüdiger Lawaczek, Susanne Wagner, Wolfgang Ebert, Volker Elste, Wolfhard Semmler, Matthias Taupitz, Josef Gaida, Anja Herrmann, Monika Jukl, Udo Swiderski
  • Acid-labile and enzymatically divisible dye compounds for diagnosis with near infrared light and for therapy
    Patent number: 6534041
    Abstract: The invention relates to acid-labile and enzymatically divisible compounds for in-vivo and in-vitro diagnosis by means of near infrared radiation (NIR-radiation), the use of said compounds as optic diagnostic and therapeutic agents, and the diagnostic agents containing said compounds.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: March 18, 2003
    Assignee: Institute for Diagnostic Research GmbH of the Free University of Berlin
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Wolfgang Wrasidlo
  • In-vivo diagnostic method by means of near infrared radiation
    Publication number: 20030026763
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Application
    Filed: June 26, 2002
    Publication date: February 6, 2003
    Applicant: Institut Fur Diagnostikforschung GmbH an der Freien Universitat Berlin
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christopher -Stephen Hilger
  • Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
    Publication number: 20020141943
    Abstract: The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes.
    Type: Application
    Filed: September 26, 2001
    Publication date: October 3, 2002
    Applicant: INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH
    Inventors: Mayk Kresse, Detlev Pfefferer, Ruediger Lawaczeck, Susanne Wagner, Wolfgang Ebert, Volker Elste, Wolfhard Semmler, Matthias Taupitz, Josef Gaida, Anja Herrmann, Monika Ebert, Udo Swiderski
  • Complex compounds for diagnosis of vascular diseases
    Patent number: 6342201
    Abstract: The present invention concerns novel complexes for use in the diagnosis of vascular diseases, methods of manufacturing such complexes and diagnostic agents containing them. These complexes strongly enrich themselves in atherosclerotic plaques and are thus suitable for use in non-invasive procedures for diagnosing atherosclerosis.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: January 29, 2002
    Assignee: Institut for Diagnostikforschung GmbH an der Freien Universitat
    Inventors: Ludger Dinkelborg, Christoph Stephan Hilger, Wolfhard Semmler, Ulrich Speck, Peter Henklein