Patents by Inventor Wolfhard Semmler

Wolfhard Semmler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In-vivo diagnostic method by means of near infrared radiation
    Publication number: 20010055567
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Application
    Filed: May 7, 2001
    Publication date: December 27, 2001
    Applicant: Institut Fur Diagnostikforschung GmbH An Der Freien Universitat Berlin
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Optical diagnostic agents for diagnosis of neurodegenerative diseases by means of near infrared radiation (NIR radiation)
    Patent number: 6329531
    Abstract: The invention relates to compounds of formula (I): Fm(—A1)(—Bn)(—Wo) wherein F is a colorant-signal molecule with a maximum absorption value ranging from 600-1200 nm; A is a &bgr;-amyloid plaque binding biomolecule; B is a &bgr;-amyloid plaque binding colorant; and W is a &bgr;-amyloid plaque binding hydrophilic low-molecular structural element. The invention also describes the use of these compounds in in vivo an din vitro diagnosis of neurodegenerative diseases such as Alzheimer's disease by means of near infra-red radiation (NIR radiation) as a constrasting agent in fluoresecence and transillumination diagnosis in the NIR range. Diagnostic agents containing said componenets are also disclosed.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: December 11, 2001
    Assignee: Schering AG
    Inventors: Jonathan Turner, Thomas Dyrks, Wolfhard Semmler, Kai Licha, Bjorn Riefke
  • In-vivo diagnostic method by near infrared radiation
    Patent number: 6258340
    Abstract: This invention relates to a in-vivo diagnostic method based on near infrared ra ation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: July 10, 2001
    Assignees: Institut fur Diagnostikforschung GmbH, der Freien Universitat Berlin
    Inventors: Kai Licha, Björn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Device for highly sensitive magnetic detection of analytes
    Patent number: 6123902
    Abstract: An apparatus for the qualitative and/or quantitative measurement of analytes, in particular in biological samples by means of receptor ligand binding and having a magnetizing device for the production of a magnetic field at the location of the sample and with a detection device for measurement of magnetic properties of the sample is characterized in that the magnetizing device is spatially disposed with respect to the detection device in such a fashion that the magnetic field produced by the magnetization device at the location of the magnetization is attenuated by at least a factor of 10, and preferentially by a factor of 1000 or more, at the location occupied by the sample during the measurement, or in that a switching device is provided for which, throughout a predetermined time duration and in particular during the measurement phase of the detection device can switch-off the magnetic field of the magnetizing device at the location of the sample.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: September 26, 2000
    Assignee: Institut Fuer Diagnostik-Forschung an Der Freien Universitaet Berlin
    Inventors: Hans Koch, Hartmut Matz, Roman Kotitz, Dietmar Drung, Lutz Trahms, Werner Weitschies, Wolfhard Semmler
  • Near infrared radiation in-vivo diagnostic methods and dyes
    Patent number: 6083485
    Abstract: This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific photophysical and pharmaco-chemical properties, as a contrast medium for fluorescence and transillumination diagnostics in the NIR range, to new dyes and pharmaceuticals containing such dyes.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: July 4, 2000
    Assignees: Institut fur Diagnostikforschung GmbH, der Freien Universitat Berlin
    Inventors: Kai Licha, Bjorn Riefke, Wolfhard Semmler, Ulrich Speck, Christoph-Stephan Hilger
  • Iron-containing nanoparticles with double coating and their use in diagnosis and therapy
    Patent number: 6048515
    Abstract: Modular iron-containing nanoparticles are disclosed, as well as their production and use in diagnosis and therapy. The nanoparticles are characterised in that they have an iron-containing core, a primary coat (synthetic polymer) and a secondary coat (target polymer), and optional auxiliary pharmaceutical substances, pharmaceuticals and/or adsorption mediators.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: April 11, 2000
    Assignees: Institut fur Diagnostikforschung GmbH, Der Freien Universitat Berline
    Inventors: Mayk Kresse, Detlev Pfefferer, Rudiger Lawaczek, Susanne Wagner, Wolfgang Ebert, Volker Elste, Wolfhard Semmler, Matthias Taupitz, Josef Gaida, Anja Herrmann, Monika Jukl, Udo Swiderski