Patents by Inventor Wu-Che Wen

Wu-Che Wen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090082425
    Abstract: The present invention relates to a tumor-inhibiting compound, in particular to verrucarin A and verrucarin J isolated from Myrothecium sp., and its use in inhibiting the growth of cancer cell including lung cancer, hepatic cancer and prostate cancer. Verrucarin A and verrucarin J in the present invention were applied in inhibiting the growth of human hepatic cancer cell lines Hep3B and HepG2, human lung cancer cell line A549, and human prostate cancer cell lines LNCaP and DU-145, which can further be used as pharmaceutical compositions for inhibition of cancers including hepatic cancer, lung cancer and prostate cancer.
    Type: Application
    Filed: February 29, 2008
    Publication date: March 26, 2009
    Inventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
  • Patent number: 7501454
    Abstract: The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: March 10, 2009
    Assignee: Golden Biotechnology Corporation
    Inventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
  • Patent number: 7468392
    Abstract: The present invention relates to a compound of Antrodia camphorata used to delay physiological fatigue, in particular to a extract isolated from Antrodia camphorata, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6-10-trienyl)-cyclohex-2-enone, and its use in delaying fatigue. Immediate supplementation of the compound according to the invention after high intensity exhausted exercise at 80% VO2max can promote the metabolism of creatine phosphate kinase and blood ammonia in human bodies, be beneficial to their recovery, further achieves the function in delaying physiological fatigue.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: December 23, 2008
    Assignee: Golden Biotechnology Corporation
    Inventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
  • Publication number: 20080312334
    Abstract: The present invention relates to a compound of Antrodia camphorata used to treat autoimmune diseases, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, isolated from Antrodia camphorata, and its use in alleviating symptoms of autoimmune diseases such as systemic lupus erythematosus (SLE). The cyclohexenone compound according to the present invention helps to decrease proteinuria levels and antinuclear antibody titers in SLE mammals in order to alleviate kidney inflammation and disease, as well as the self-damage caused by antinuclear antibodies. The purpose for prevention and treatment of autoimmune diseases and kidney diseases by the natural, side-effect free substance can then be accomplished.
    Type: Application
    Filed: July 31, 2007
    Publication date: December 18, 2008
    Applicant: Golden Biotechnology Corporation
    Inventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
  • Publication number: 20080312335
    Abstract: The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorate. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPX) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.
    Type: Application
    Filed: September 24, 2007
    Publication date: December 18, 2008
    Inventors: Sheng-Yun Liu, Wu-Che Wen, Mao-Tien Kuo
  • Publication number: 20080312474
    Abstract: The present invention relates to a compound of Antrodia camphorata used to delay physiological fatigue, in particular to a extract isolated from Antrodia camphorata4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, and its use in delaying fatigue. Immediate supplementation of the compound according to the invention after high intensity exhausted exercise at 80%VO2max can promote the metabolism of creatine phosphate kinase and blood ammonia in human bodies, be beneficial to their recovery, further achieves the function in delaying physiological fatigue.
    Type: Application
    Filed: July 27, 2007
    Publication date: December 18, 2008
    Inventors: Sheng-Yun LIU, Mao-Tien Kuo, Wu-Che Wen
  • Patent number: 7456225
    Abstract: The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPx) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: November 25, 2008
    Assignee: Golden Biotechnology Corporation
    Inventors: Sheng-Yun Liu, Wu-Che Wen, Mao-Tien Kuo
  • Publication number: 20080226749
    Abstract: The present invention discloses a pharmaceutical composition for inhibiting a snore symptom, which comprises medicinal material of Uncaria rhynchophylla. The above pharmaceutical composition of the present invention also comprises medicinal materials of Uncaria rhynchophylla, Ephedra, Prunus armeniaca, and Glycyrrhiza uralensis.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 18, 2008
    Applicant: Brion Research Institute of Taiwan
    Inventors: Shuenn-Jyi Sheu, Hsiao-Yin Yeh, Wu-Che Wen, Ching-Che Lin, Chen-Ying Chiang
  • Patent number: 7411003
    Abstract: The present invention relates to a compound of Antrodia camphorata used to inhibit HBV, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata, and its use in inhibiting HBV effectively. The cyclohexenone compound according to the present invention showed cytotoxicity on HBV-secreting human hepatoma cell line HepG2 2.2.15, decreased synthesis of HBV particles, further inhibited synthesis of HbsAg and HbeAg effectively to achieve the goal of HBV inhibition.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: August 12, 2008
    Assignee: Golden Biotechnology Corporation
    Inventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
  • Patent number: 7385088
    Abstract: The present invention relates to a novel compound and use thereof, in particular to Antroquinonol B and Antroquinonol C isolated from Antrodia camphorata extracts which can effectively inhibit the growth of cancer cells. The compounds from Antrodia camphorata are first reported, which can be applied not only in inhibiting growth of breast cancer, lung cancer, hepatic cancer and prostate cancer, but also in anti-cancer medicinal compositions for the abovementioned cancer cells.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: June 10, 2008
    Assignee: Golden Biotechnology Corporation
    Inventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
  • Publication number: 20080119565
    Abstract: The present invention relates to a novel compound and use thereof, in particular to Antroquinonol B and Antroquinonol C isolated from Antrodia camphorata extracts which can effectively inhibit the growth of cancer cells. The compounds from Antrodia camphorata are first reported, which can be applied not only in inhibiting growth of breast cancer, lung cancer, hepatic cancer and prostate cancer, but also in anti-cancer medicinal compositions for the abovementioned cancer cells.
    Type: Application
    Filed: January 29, 2008
    Publication date: May 22, 2008
    Applicant: Golden Biotechnology Corporation
    Inventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
  • Publication number: 20080103195
    Abstract: The present invention relates a compound for inhibiting the growth of tumor cells. More specifically, the compound of the present invention is 4,7-dimethoxy-5-methy-1,3-benzodioxole. 4,7-dimethoxy-5-methy-1,3-benzodioxole of the present invention is used for inhibiting the growth of tumor cells of breast cancer, liver cancer, and prostate cancer, and the pharmaceutical composition comprises an effective dose of 4,7-dimethoxy-5-methy-1,3-benzodioxole.
    Type: Application
    Filed: May 16, 2007
    Publication date: May 1, 2008
    Inventors: Sheng-Yun Liu, Wu-Che Wen, Wan-Ling Tsou, Mao-Tien Kuo
  • Publication number: 20080063734
    Abstract: A medical herb composition for the alleviation of cardiopulmonary ailments or the improvement of cardiopulmonary function in a mammal is disclosed. The medical herb composition comprises: Schisandra extract; Ginseng extract; Radix ophiopogonis extract; and Saliva miltiorrhiza extract. The medical herb composition comprising the extracts above is proved to be efficient in enhancing cardiopulmonary function of a mammalian patient without heart disease, enforcing energy and raising strength. The medical herb composition is also capable of reducing the symptoms of breathing difficulties and stagnation of vital energy.
    Type: Application
    Filed: August 23, 2007
    Publication date: March 13, 2008
    Applicant: Brion Research Institute of Taiwan
    Inventors: Shuenn-Jyi Sheu, Hsiao-Yin Yeh, Wu-Che Wen, Ching-Che Lin, Chen-Ying Chiang
  • Patent number: 7342137
    Abstract: The present invention relates to a novel compound and its uses, which is an extract isolated and purified from Antrodia camphorate, in particular to 4-hydroxy-2,3 -dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, and its use in tumor growth inhibition. The compound of the invention, which has never been discovered in Antrodia camphorate, can be applied in inhibiting the growth of cancer cells, such as breast cancer, hepatic cancer and prostate cancer; and be used as a pharmaceutical composition to inhibit the tumor growth; or further be applied in prevention of heart and blood vessel disease or dietary supplements for health needs through its antioxidant activity.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: March 11, 2008
    Assignee: Golden Biotechnology Corporation
    Inventors: Sheng-Yun Liu, Wu-Che Wen, Wan-Ling Tsou, Mao-Tien Kuo, Chun-Hung Huang, Ka-Hang Fok, Ya-Ying Li, Chun-Chou Chang
  • Publication number: 20070292451
    Abstract: A medical herb composition for promoting the growth of hair of a mammal is disclosed. The medical herb composition comprises: an extract of Sophorae Radix; an extract of at least one vital-energy-invigorating plant; and an extract of at least one blood-nourishing plant. Moreover, the weight percentage of the extract of Sophorae Radix is 2-38, the weight percentage of the extract of the vital-energy-invigorating plant is 2-60, and the weight percentage of the extract of the blood-nourishing plant is 2-60. In addition, the medical herb composition can optionally further comprise an extract of at least one skin-pathogen-expelling plant, an extract of at least one diuresis-inducing plant, an extract of at least one heat-clearing plant, an extract of at least one spleen-invigorating plant, or/and an extract of at least one dampness-removing plant. The disclosed medical herb composition can also be used to treat skin disorders of a mammal.
    Type: Application
    Filed: June 1, 2007
    Publication date: December 20, 2007
    Applicant: Brion Research Institute of Taiwan
    Inventors: Shuenn-Jyi Sheu, Hsiao-Yin Yeh, Chung-Lin Yu, Wu-Che Wen, Ching-Che Lin, Chen-Ying Chiang