Abstract: Methods of treatment, genetic screening, and disease models for heart conditions associated with RBM20 deficiency are disclosed. In particular, methods of treating heart conditions associated with RBM20 deficiency, including RBM20-dependent dilated cardiomyopathy and heart failure with compounds that upregulate expression of RBM20, such as all-trans retinoic acid are provided. Also disclosed are methods of genetic screening to detect the presence of a P633L mutation in RBM20 in order to identify individuals having a genetic predisposition to developing RBM20-dependent DCM. Induced pluripotent stem cell-derived cardiomyocytes (IPSC-CMs) produced by differentiation of IPSCs comprising at least one RBM20 allele encoding a P633L mutation and methods of using them in screening for therapeutics for treating RBM20-dependent DCM are also disclosed.

Abstract: A semiconductor device and a lead frame. The semiconductor device comprises at least one semiconductor chip that is attached to a surface of a base island in a first plane, wherein a connecting rib is connected to the base island, and has a first part which is obliquely connected to the base island; the connecting rib has a second part, and the second part has a surface in a second plane; the second plane is parallel to the first plane and is a plane different from the first plane; the connecting rib has a branch part divided from the second part and the branch part has, in the second plane, a surface used for receiving a lead connected to the semiconductor chip; and the branch part has an edge which is distant from a first edge of the base island by a first distance.

Abstract: Disclosed are a packaging substrate, a grid array package, and a preparation method therefor. The packaging substrate comprises a plurality of packaging units, and each packaging unit is defined by a closed packaging line. The packaging substrate comprises: a base substrate having a first surface and a second surface that are opposite to each other, a plurality of solder pads provided on the first surface, and a metal layer provided on the second surface. In a given packaging unit, the metal layer comprises a plurality of lead pads, at least one lead pad extending from an inner side of the packaging unit defined by the packaging line to an outer side. The lead pad is connected to one solder pad by means of a connecting member penetrating through the base substrate, and an orthographic projection of the connecting member on the base substrate at least partially covers the packaging line.

Abstract: Methods of treatment, genetic screening, and disease models for heart conditions associated with RBM20 deficiency are disclosed. In particular, methods of treating heart conditions associated with RBM20 deficiency, including RBM20-dependent dilated cardiomyopathy and heart failure with compounds that upregulate expression of RBM20, such as all-trans retinoic acid are provided. Also disclosed are methods of genetic screening to detect the presence of a P633L mutation in RBM20 in order to identify individuals having a genetic predisposition to developing RBM20-dependent DCM. Induced pluripotent stem cell-derived cardiomyocytes (IPSC-CMs) produced by differentiation of IPSCs comprising at least one RBM20 allele encoding a P633L mutation and methods of using them in screening for therapeutics for treating RBM20-dependent DCM are also disclosed.

Abstract: Aspects include detecting, by an agent of a remote debugging tool that a first controller currently associated with the agent for a debugging session has not responded to a status inquiry from the agent. The first controller interacts with an end user, sends requests to the agent to operate a target program, and processes responses from the agent. Based on detecting that the first controller has not responded to the status inquiry from the agent, the agent identifies a second controller, associates the second controller with the agent for the debugging session, and resumes the debugging session with the second controller in place of the first controller. The associating includes synchronizing a debugging session state between the second controller and the agent. The target program continues to execute during the identifying, associating, and resuming, and the debugging session state is not changed by the identifying, associating, and resuming.

Abstract: Aspects include detecting, by an agent of a remote debugging tool that a first controller currently associated with the agent for a debugging session has not responded to a status inquiry from the agent. The first controller interacts with an end user, sends requests to the agent to operate a target program, and processes responses from the agent. Based on detecting that the first controller has not responded to the status inquiry from the agent, the agent identifies a second controller, associates the second controller with the agent for the debugging session, and resumes the debugging session with the second controller in place of the first controller. The associating includes synchronizing a debugging session state between the second controller and the agent. The target program continues to execute during the identifying, associating, and resuming, and the debugging session state is not changed by the identifying, associating, and resuming.

Abstract: The present disclosure relates to a method, system, and computer program product for integrating data between a plurality of different enterprise systems. An illustrative embodiment of the disclosure provides a method for integrating data between different systems, comprising: acquiring a user interface metadata for each of a plurality of enterprise systems, wherein the user interface metadata of an enterprise system corresponds to data in the same enterprise system and describes how the data should be presented on a user interface of the enterprise system; in response to acquiring the user interface metadata for each of the plurality of enterprise systems, generating a user interface presentation for each of the plurality of enterprise systems according to the user interface metadata; and establishing, for each of the plurality of enterprise systems, a first mapping between the user interface presentation and a structure of the data.

Abstract: A leakage protection method and device having a live/neutral wire identification function that identify the live wire and neutral wire of an input power source by means of a live/neutral wire identification device 1.

Abstract: The present disclosure relates to a method, system, and computer program product for integrating data between a plurality of different enterprise systems. An illustrative embodiment of the disclosure provides a method for integrating data between different systems, comprising: acquiring a user interface metadata for each of a plurality of enterprise systems, wherein the user interface metadata of an enterprise system corresponds to data in the same enterprise system and describes how the data should be presented on a user interface of the enterprise system; in response to acquiring the user interface metadata for each of the plurality of enterprise systems, generating a user interface presentation for each of the plurality of enterprise systems according to the user interface metadata; and establishing, for each of the plurality of enterprise systems, a first mapping between the user interface presentation and a structure of the data.

Abstract: A multi-attach reusable security tag (MARST) that is attached to an article in two stages. In a first stage, an attachment clip is coupled to an article, such as but not limited to clothing, to be protected by a manufacturer or assembler. This attachment clip is durable to withstand harsh manufacturing environments. Once the article with the attachment clip is ready for presentation, for example, at a retail establishment, during a second stage, the attachment clip is then secured in a releasable locking mechanism of a housing containing a security element therein. The security element may comprise EAS (including AM, RF, EM and microwave), RFID (including LF, HF and UHF) elements or any combination thereof. Alternatively, a fluke element can be used to secure the attachment clip to the releasable locking mechanism and wherein this fluke element permits the attachment clip to swivel outside of the housing.

Abstract: A multi-attach disposable security tag that is attached to an article in two stages. In a first stage, an attachment clip is coupled to an article, such as but not limited to clothing, to be protected by a manufacturer or assembler. This attachment clip is durable to withstand harsh manufacturing environments. Once the article with the attachment clip is ready for presentation, for example, at a retail establishment, during a second stage, the attachment clip is then permanently secured in a locking mechanism of a housing containing a deactivatable security element therein. The security element may comprise EAS (including AM, RF, EM and microwave), RFID (including LF, HF and UHF) elements or any combination thereof. A preferred embodiment of the security tag uses all non-ferrous components including its locking mechanism.

Abstract: The present invention is directed to a thermostatic water mixing valve having a sub-base coupled to a base, both having a hot water inlet, a cold water inlet and a mixed water outlet. A disk assembly including a lower or stationary disk and an upper or rotatable disk are positioned on the base. The lower disk also has a peripheral notch that receives an extent of an engaging member that extends from a sidewall of the base, while the upper disk has a peripheral cavity that also receives an extent of the engaging member. A cap is coupled to the upper disk, wherein the cap and the upper disk rotate as a unit with respect to the lower disk. The cap has a hot water cavity and cold water cavity positioned about a central opening. A cartridge assembly includes a collar with at least one aperture aligned with the cold water cavity of the cap and a depending skirt with at least one aperture aligned with the hot water cavity of the cap.

Abstract: The present invention is directed to a thermostatic water mixing valve having a sub-base coupled to a base, both having a hot water inlet, a cold water inlet and a mixed water outlet. A disk assembly including a lower or stationary disk and an upper or rotatable disk are positioned on the base. Each disk includes a hot water inlet, a cold water inlet and a central opening. The lower disk also has a peripheral notch that receives an extent of an engaging member that extends from a sidewall of the base, while the upper disk has a peripheral cavity that also receives an extent of the engaging member. A cap is coupled to the upper disk, wherein the cap and the upper disk rotate as a unit with respect to the lower disk. The cap has a hot water cavity and cold water cavity positioned about a central opening. A cartridge assembly extends through the cap and includes a collar with at least one aperture aligned with the cold water cavity of the cap.