Patents by Inventor Xavier Cayla

Xavier Cayla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pro-apoptotic peptides
    Patent number: 8957184
    Abstract: The invention relates to chimeric peptides useful as pro-apoptotic agents, for inhibition of in vitro cell proliferation and for treatment of tumors.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: February 17, 2015
    Inventors: Angelita Rebollo Garcia, Alphonse Garcia, Xavier Cayla, Issam Arrouss, Katy Billot, Angelique Godet
  • Synthetic or natural peptides binding protein phosphatase 2A, identification method and uses
    Patent number: 8299213
    Abstract: The present invention relates to novel synthetic or natural peptides for use in treating viral or parasitic infections or in the treatment of tumors. The peptides of the present invention are less than 30 amino acids in size, preferably less than 20 amino acids, in particular 15 to 20 amino acids, and in vitro the peptides specifically bind a type 2A protein phosphatase holoenzyme or one of its subunits. The invention also relates to a method for identifying said peptides, and to their uses.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: October 30, 2012
    Assignee: Universite Pierre et Marie Curie (Paris 6)
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo, Gordon Langsley
  • PRO-APOPTOTIC PEPTIDES
    Publication number: 20120021999
    Abstract: The invention relates to chimeric peptides useful as pro-apoptotic agents, for inhibition of in vitro cell proliferation and for treatment of tumors.
    Type: Application
    Filed: March 29, 2010
    Publication date: January 26, 2012
    Inventors: Angelita Rebollo Garcia, Alphonse Garcia, Xavier Cayla, Issam Arrouss, Katy Billot, Angelique Godet
  • SYNTHETIC OR NATURAL PEPTIDES BINDING PROTEIN PHOSPHATASE 2A, IDENTIFICATION METHOD AND USES
    Publication number: 20110269674
    Abstract: The present invention relates to novel synthetic or natural peptides for use in treating viral or parasitic infections or in the treatment of tumors. The peptides of the present invention are less than 30 amino acids in size, preferably less than 20 amino acids, in particular 15 to 20 amino acids, and in vitro the peptides specifically bind a type 2A protein phosphatase holoenzyme or one of its subunits. The invention also relates to a method for identifying said peptides, and to their uses.
    Type: Application
    Filed: March 4, 2011
    Publication date: November 3, 2011
    Applicant: UNIVERSITE PARIS 6 PIERRE ET MARIE CURIE
    Inventors: ALPHONSE GARCIA, XAVIER CAYLA, ANGELITA REBOLLO, GORDON LANGSLEY
  • METHODS OF SCREENING OF PP1-INTERACTING POLYPEPTIDES OR PROTEINS, PEPTIDES INHIBITING PP1c BINDING TO Bcl-2 PROTEINS, BCL-XL AND BCL-W, AND USES THEREOF
    Publication number: 20110028387
    Abstract: The invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as Bcl-xL and Bcl-w).
    Type: Application
    Filed: April 6, 2010
    Publication date: February 3, 2011
    Applicant: INSTITUT PASTEUR
    Inventors: ALPHONSE GARCIA, XAVIER CAYLA, ANGELITA REBOLLO
  • Methods of screening of PP1-interacting polypeptides or proteins, peptides inhibiting PP1c binding to Bcl-2 proteins, Bcl-xand Bcl-w, and uses thereof
    Patent number: 7741288
    Abstract: The present invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as BCl-xL and Bcl-w), and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: June 22, 2010
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale, Universite Pierre et Marie Curie (Paris 6), Institut National de la Recherche Agronomique (INRA)
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo
  • PEPTIDES BINDING THE PHOSPHATASE 2A PROTEIN
    Publication number: 20100009909
    Abstract: The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids long and binding in vitro to a phosphatase 2A protein holoenzyme or one of its subunits. The invention also relates to polynucleotides encoding the novel peptides, vectors expressing same, as well as antibodies identifying same and probes identifying transcripts thereof.
    Type: Application
    Filed: January 12, 2009
    Publication date: January 14, 2010
    Applicant: INSTITUT PASTEUR
    Inventors: Alphonse Garcia, Frederic Dessauge, Xavier Cayla, Angelita Rebollo
  • Peptides binding to the phosphatase 2A protein
    Patent number: 7498306
    Abstract: The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids long and binding in vitro to a phosphatase 2A protein holoenzyme or one of its subunits. The invention also relates to polynucleotides encoding the novel peptides, vectors expressing same, as well as antibodies identifying same and probes identifying transcripts thereof.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: March 3, 2009
    Assignee: Institut Pasteur
    Inventors: Alphonse Garcia, Frederic Dessauge, Xavier Cayla, Angelita Rebollo
  • METHODS OF SCREENING APOPTOSIS MODULATING COMPOUNDS, COMPOUNDS IDENTIFIED BY SAID METHODS AND USE OF SAID COMPOUNDS AS THERAPEUTIC AGENTS
    Publication number: 20070184435
    Abstract: A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type, said method comprising: (a) culturing cells of said particular cell-type under non apoptotic conditions and culturing cells of said particular cell-type under apoptotic conditions, and (b) determining subcellular localisation of said cellular polypeptides in the cultured cells, wherein a localization of a cellular polypeptide in lipid rafts in cultured cells under non apoptotic conditions and a segregation of said cellular polypeptide from lipid rafts in cultured cells under apoptotic conditions is indicative that said cellular polypeptide has a pro-apoptotic or an anti-apoptotic activity in said particular cell-type.
    Type: Application
    Filed: April 5, 2007
    Publication date: August 9, 2007
    Applicants: INSTITUT PASTEUR, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alphonse GARCIA, Xavier Cayla, Angelita Rebollo, Veronica Ayllon, Aarne Fleischer
  • Methods of screening apoptosis modulating compounds, compounds identified by said methods and use of said compounds as therapeutic agents
    Patent number: 7217534
    Abstract: A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type by: (a) culturing cells of the particular cell-type under non apoptotic conditions and culturing cells of the particular cell-type under apoptotic conditions, and (b) determining subcellular localization of the cellular polypeptides in the cultured cells, wherein a localization of a cellular polypeptide in lipid rafts in cultured cells under non apoptotic conditions and a segregation of the cellular polypeptide from lipid rafts in cultured cells under apoptotic conditions is indicative that the cellular polypeptide has a pro-apoptotic or an anti-apoptotic activity in the particular cell-type.
    Type: Grant
    Filed: May 31, 2005
    Date of Patent: May 15, 2007
    Assignees: Institut Pasteur, Consejo Superior de Investigaciones Cientificas, Centre National de la Recherche Scientifque
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo, Veronica Ayllon, Aarne Fleischer
  • Peptides binding the phosphatase 2A protein and polynucleotides encoding same
    Publication number: 20070065410
    Abstract: The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids long and binding in vitro to a phosphatase 2A protein holoenzyme or one of its subunits. The invention also relates to polynucleotides encoding the novel peptides, vectors expressing same, as well as antibodies identifying same and probes identifying transcripts thereof.
    Type: Application
    Filed: April 18, 2005
    Publication date: March 22, 2007
    Applicant: INSTITUT PASTEUR
    Inventors: Alphonse Garcia, Frederic Dessauge, Xavier Cayla, Angelita Rebollo
  • Methods of screening apoptosis modulating compounds, compounds identified by said methods and use of said compounds as therapeutic agents
    Publication number: 20060040331
    Abstract: A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type, said method comprising: (a) culturing cells of said particular cell-type under non apoptotic conditions and culturing cells of said particular cell-type under apoptotic conditions, and (b) determining subcellular localisation of said cellular polypeptides in the cultured cells, wherein a localization of a cellular polypeptide in lipid rafts in cultured cells under non apoptotic conditions and a segregation of said cellular polypeptide from lipid rafts in cultured cells under apoptotic conditions is indicative that said cellular polypeptide has a pro-apoptotic or an anti-apoptotic activity in said particular cell-type.
    Type: Application
    Filed: May 31, 2005
    Publication date: February 23, 2006
    Applicants: INSTITUT PASTEUR, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo, Veronica Ayllon, Aarne Fleischer
  • Synthetic or natural peptides binding protein phosphatase 2A, identification method and uses
    Publication number: 20060014930
    Abstract: The present invention relates to novel synthetic or natural peptides for use in treating viral or parasitic infections or in the treatment of tumors. The peptides of the present invention are less than 30 amino acids in size, preferably less than 20 amino acids, in particular 15 to 20 amino acids, and in vitro the peptides specifically bind a type 2A protein phosphatase holoenzyme or one of its subunits. The invention also relates to a method for identifying said peptides, and to their uses.
    Type: Application
    Filed: January 26, 2004
    Publication date: January 19, 2006
    Applicants: INSTITUT PASTEUR, Institut National de la Recherche Agronomique, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, Centre National De La Recherche Scient.
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo, Gordon Langsley
  • Methods of screening of PP1-interacting polypeptides or proteins, peptides inhibiting PP1c binding to Bcl-2 proteins, Bcl-xL and Bcl-w, and uses thereof
    Publication number: 20050244844
    Abstract: The present invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as BCl-xL and Bcl-w), and pharmaceutical compositions comprising the same.
    Type: Application
    Filed: November 8, 2004
    Publication date: November 3, 2005
    Applicant: INSTITUT PASTEUR
    Inventors: Alphonse Garcia, Xavier Cayla, Angelita Rebollo