Abstract: Provided are an RNA plasmid delivery system and an application thereof. The RNA plasmid delivery system comprises a plasmid carrying an RNA fragment required to be delivered; the plasmid can be enriched in an organ tissue of a host, and spontaneously forms an exosome containing the RNA fragment in the organ tissue of the host, and therefore can enter and be combined with a target tissue to deliver the RNA fragment into the target tissue. The RNA delivery system is safe, reliable, good in druggability, and strong in universality.

Abstract: Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.

Abstract: An RNA delivery system for the treatment of Huntington's disease. The system comprises a viral vector, the viral vector carries RNA fragments capable of treating Huntington's disease, the viral vector is capable of enrichment in organ tissues of a host and endogenously and spontaneously forming a complex containing the RNA fragments capable of treating Huntington's disease in the organ tissues of the host, and the complex can deliver the RNA fragments into a target tissue to treat Huntington's disease. The safety and reliability of the RNA delivery system for the treatment of Huntington's disease have been fully verified. The system has good medicinal properties, strong versatility, and has economic benefits and application prospects.

Abstract: Provided are a viral vector-based RNA delivery system and a use thereof. The RNA delivery system comprises a viral vector. The viral vector carries an RNA fragment needing to be delivered, and can be enriched in organ tissues of a host. In the host organ tissues, the viral vector can endogenously and spontaneously form a composite structure containing the RNA fragment. The composite structure can enter and bind to target tissues, and feed the RNA fragment into the target tissues. The viral vector has a targeting tag. The composite structure is an exosome. The viral vector RNA delivery system is safe and reliable, and has good druggability and high universality.

Abstract: A method and device for milling a large-diameter aspheric surface by using a splicing method and a polishing method to solve the problems of large time consumption and serious tool wear in the machining of a meter-scale large-diameter aspheric surface are disclosed. where an aspheric surface is discretized into a series of rings with different radii, and the rings are sequentially machined via generating cutting by using an annular grinding wheel tool with an outer diameter less than ¼ of a diameter of the aspheric surface; the rings are equally spaced, there are a total of N rings, and a width of any ring is jointly determined by the Nth ring, the (N?1)th ring, positioning accuracy and a generatrix equation of the aspheric surface; and the aspheric surface is enveloped by a large number of rings. A contact area between the tool and a workpiece surface is rings.

Abstract: A lock, a vehicle parking system, and a vehicle parking method are provided. The lock includes a main body, a lock switch, a lock controller, a lock communication circuit, and a battery. The battery is connected to the lock switch, the lock controller, and the lock communication circuit, and configured to supply electrical energy to the lock switch, the lock controller, and the lock communication circuit. The lock communication circuit is connected to the lock controller, and transmits a locking instruction or an unlocking instruction to the lock controller when receiving the locking instruction or the unlocking instruction from a second device located outside the lock. The lock controller is connected to the lock switch connected to the main body, and the lock controller controls, when receiving the locking instruction or the unlocking instruction, the main body to perform a locking operation or an unlocking operation through the lock switch.

Abstract: A building photovoltaic data interpolation method based on WGAN and whale optimization algorithm is provided, which includes: obtaining historical building roof photovoltaic output data, perform preprocessing on the historical building roof photovoltaic output data, and uses CNN to build a GAN; describing missing value position of preprocessed data by using a binary mask matrix, and setting Wasserstein distance to define a loss function of a GAN generator and a discriminator; taking the loss function as a fitness function, optimizing an input to the GAN generator through a whale optimization algorithm and obtaining optimized candidate samples; fusing the optimized candidate samples and a photovoltaic data processed by the binary mask matrix to obtain completed reconstructed samples, so as to improve the complementary accuracy, optimize the random noise, remove the unfavorable influencing components, and provide services for building rooftop PV data interpolation more accurately.

Abstract: The present disclosure provides an anti-tumor polypeptide Bax-BH3, a fluorescent polymeric nanomicelle, a preparation method and use thereof, belonging to the technical field of medicines. The anti-tumor polypeptide Bax-BH3 has an amino acid sequence set forth in SEQ ID No: 1; the fluorescent polymeric nanomicelle includes the anti-tumor polypeptide Bax-BH3 and a polymer carrier; and the polymer carrier is a block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)). In the present disclosure, the anti-tumor polypeptide Bax-BH3 has desirable biocompatibility and biological activity; and the fluorescent polymeric nanomicelle encapsulates the anti-tumor polypeptide Bax-BH3 by the block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)), with high encapsulation rate and drug loading, and good release performance.

Abstract: The invention relates to the field of aluminum wheel casting molds, and more particularly relates to a closed-loop control method and system for a mold temperature in a wheel casting process. The control method includes: step 1, acquiring data, that is, acquiring a plurality of mold position temperatures, and cooling pipeline opening and closing signals in a target wheel casting process according to a fixed frequency; step 2, storing, based on acquired mold opening and closing signals of casting equipment, the acquired data in a database in the form of a unique ID according to a single wheel casting process; step 3, calculating new process parameters based on the acquired plurality of position temperatures and time; and step 4, integrating the calculated process parameters, and issuing the process parameters to a PLC of a casting equipment to perform new casting.

Abstract: A battery pack electrically connected to an electrical device for power supply or connected to a charging device for charging, including an information acquiring module and a communication module.

Abstract: A battery management circuit a logic control module configured to output a power control signal in response to receiving a logic-enable signal, and to skip outputting a power control signal in response to receiving no logic-enable signal; a power control module configured to turn on the power supply from a battery to the main control module in response to receiving a power control signal from the logic control module, and to turn off the power supply from the battery to the main control module in response to receiving no power control signal from the logic control module; a main control module configured to send a logic-enable signal to the logic control module when powered from a battery, and to skip sending the logic-enable signal to the logic control module when in a first predetermined state.

Abstract: A foldable adjustable photovoltaic module, comprising angle adjusting device, comprising adjusting component and basic photovoltaic panel on the adjusting component; and folding device, comprising first and second folding components, is provided. One end of the basic photovoltaic panel is installed with protective photovoltaic panel, and the first folding component is between the basic and the protective photovoltaic panels. Both sides of the basic and the protective photovoltaic panels are provided with side photovoltaic panels, and the second folding component connects the side photovoltaic panels, the basic photovoltaic panel and the protective photovoltaic panel. The module can control multiple photovoltaic panels for angle adjustment, so as to conveniently obtain the optimal illumination angle.

Abstract: The present disclosure provides a boom, a boom assembly and a work machine. The work machine comprises a boom support structure and the boom assembly connected to the boom support structure, wherein the boom assembly comprises a plurality of first booms hinged to one another, at least one of the first boom is the boom, the boom has a box-type structure and comprises a body comprising a first body portion and a second body portion, the first body portion and the second body portion overlapping each other to enclose and form the box-type structure. The boom can be designed to have a light weight, and a split-type design facilitates simplifying a mold, improving the versatility of a mold, alleviating the inconsistent of thermal deformation of the boom, and facilitating later maintenance.

Abstract: Electronic device package on package (POP) technology is disclosed. A POP can comprise a first electronic device package including a heat source. The POP can also comprise a second electronic device package disposed on the first electronic device package. The second electronic device package can include a substrate having a heat transfer portion proximate the heat source that facilitates heat transfer from the heat source through a thickness of the substrate. The substrate can also have an electronic component portion at least partially about the heat transfer portion that facilitates electrical communication. In addition, the POP can comprise an electronic component operably coupled to the electronic component portion.

Abstract: Embodiments of this application provide an article display processing method and apparatus and an electronic device. An exemplary method includes: displaying a plurality of articles on a webpage, each of the plurality of articles being associated with an user interface; receiving a user selection of the user interface associated with a selected article from a first user; obtaining an environment template corresponding to the selected article, wherein the environment template is a digitally-generated simulated environment and stored in a database; generating a display image comprising the environment template fused with the selected article as a main view angle according to feature data of the selected article; and sending the display image to a client device of the first user for display.

Abstract: Methods, systems, and computer programs are presented for estimating disease-spreading based on facility and behavioral parameters. One method includes an operation for causing presentation of a user interface (UI) for entering facility parameters. The method further includes an operation for calculating the number of infections at the facility for a predetermined time period. The calculation includes setting values for simulation parameters based on the facility parameters, modeling a contact network for people at the facility, and performing a plurality of simulations to determine the number of infections, the plurality of simulations based on the contact network and the facility simulation parameters. Further, the method includes an operation for causing presentation of the number of infections in the UI.

Abstract: The disclosed computer-implemented method for identifying and mitigating phishing attacks may include (i) receiving a request for sensitive data utilized to access a network service, (ii) launching an autofill provider for providing the sensitive data to the network service, (iii) identifying, utilizing the autofill provider, a domain for the network service and a data type associated with the sensitive data utilized to access the network service, (iv) determining, utilizing the autofill provider, a reputation for the network service based on the domain and the data type, and (v) performing a security action that protects against a phishing attack based on the reputation determined for the network service. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A quinoline derivative used for soft tissue sarcoma combination therapy, relating to a use of the quinoline derivative in combination with a second therapeutic drug to treat soft tissue sarcoma, wherein the second therapeutic drug may be a chemotherapy drug, a small molecule targeted anti-tumour drug or an immunotherapy drug. The chemical name of the quinoline derivative compound I is 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]methyl]cyclopropylamine.

Abstract: A computer-implemented method for fording depth estimation based on a real-time image recognition is provided according an embodiment of the present disclosure. In the method, a first image of a low-lying road being submerged under a bridge can be acquired. At least one second image of the low-lying road without being submerged can be determined. A fording depth of the low-lying road can be estimated based on the first image and the at least one second image.

Abstract: The present techniques are related a dock with a cooling solution. The performance dock includes a thermoelectric device, an alignment mechanism, and an air mover. The alignment mechanism is to align the computing device when docking the computing device, and the thermoelectric device is to cool the computing device when docked, and the air mover is to enable an airflow through the dock to cool the thermoelectric device when the computing device is docked.