Abstract: A recombinant AAV vector including a sequence for introducing the expression of G protein-coupled receptor 173 (GPR173) and specifically targeting GPR173 expressing neurons in a brain is provided. A method of restoring the excitatory/inhibitory (E/I) balance in brain or for prophylaxis and/or therapy of a neurological condition in a subject in need thereof by administrating the recombinant AAV vector or a GPR173 agonist to the subject is also provided.

Abstract: A bidirectional transmission circuit for a universal signal, comprising an intrinsically safe energy limiting module, a first signal coupling module, an isolation transformer module, a second signal coupling module and a control module; the first signal coupling module adjusts a first direct current signal of a universal signal to a first alternating current signal, the isolation transformer module transmits the first alternating current signal to the second signal coupling module in an isolation manner, and the second signal coupling module adjusts the first alternating current signal to a second direct current signal to a universal signal receiving terminal; the second signal coupling module further adjusts a third direct current signal of a control signal to a second alternating current signal, and the first signal coupling module further adjusts the second alternating current signal to a fourth direct current signal to a control signal receiving terminal.

Abstract: Disclosed are techniques for compressing data of an image. Intermediate pixels may be determined. Each location of the image may be associated with a block of a plurality of blocks of a first size and a block of a plurality of blocks of a second size. For each block of the first size and of the second size, a first cost for a first mode and a second cost for a second mode may be determined in parallel using the intermediate pixels. A final mode and a final block size may be selected for each location of the image using the first cost and the second cost for each of a respective block of the first size and a respective block of the second size associated with a corresponding location. Final pixels may be determined, and a representation of the image may be obtained based on the final pixels.

Abstract: The disclosure describes methods for measuring the potency of anti-Respiratory Syncytial Virus (RSV) antibody against respiratory syncytial virus in a cell culture system using an RSV reporter virus. The disclosure also describes respiratory syncytial viruses that carry a reporter gene, and expression vectors for producing an infectious recombinant respiratory syncytial virus (RSV) that carry a reporter gene.

Abstract: This application provides materials and methods related to replication competent, noninfectious coronavirus reporter replicons, such as for SARS-CoV-2, MERS, or SARS-CoV-1 comprising at least one coronavirus gene and at least one reporter gene. The application also provides methods for assaying candidate agents for inhibition of coronavirus viral replication.

Abstract: A fastener tool includes a motor, a drive mechanism connected to the motor and adapted to drive a piston, and a cylinder filled with compressed gas. The piston is accommodated in the cylinder and suitable for a reciprocating motion within the cylinder. The drive mechanism includes a blade fixed to the piston, and a gear coupled to the motor. The gear contains a plurality of teeth adapted to engage with a plurality of lugs on the blade such that a rotation of the gear is transformed to a linear movement of the blade. The drive mechanism further includes a disengagement module which within a period of a rotation cycle of the gear, is configured to prevent one of the plurality of teeth from unintentionally engaging with a misaligned one of the lugs.

Abstract: Disclosed are apparatuses, systems, and techniques that may perform methods of pyramid optical flow processing with efficient identification and handling of object boundary pixels. In pyramid optical flow, motion vectors for pixels of image layers having a coarse resolution may be used as hints for identification of motion vectors for pixels of image layers having a higher resolution. Pixels that are located near apparent boundaries between foreground and background objects may receive multiple hints from lower-resolution image layers, for more accurate identification of matching pixels across different image levels of the pyramid.

Abstract: A fastener tool includes a motor, a drive mechanism connected to the motor and adapted to drive a piston, and a cylinder filled with high-pressure gas. The piston is accommodated in the cylinder and suitable for a reciprocating motion within the cylinder. The drive mechanism includes a blade fixed to the piston and a gear coupled to the motor. The gear contains a plurality of teeth adapted to engage with a plurality of lugs on the blade such that a rotation of the gear is transformed to a linear movement of the blade. The drive mechanism further includes a disengagement module which, within a period of a rotation cycle of the gear, is configured to prevent one of the plurality of teeth from unintentionally engaging with a misaligned one of the lugs.

Abstract: Disclosed are techniques for compressing data of an image using multiple processing cores. The techniques include obtaining, using a first (second, etc.) processing core, a first (second, etc.) plurality of reconstructed blocks approximating source pixels of a first (second, etc.) portion of an image and filtering, using the first processing core, the first plurality of reconstructed blocks. The filtering includes enabling application of one or more filters to a first plurality of regions that include pixels of the first plurality of reconstructed blocks but not pixels of the second plurality of reconstructed blocks. The filtering further includes disabling application of the one or more filters to a second plurality of regions that include pixels of the first plurality of reconstructed blocks and pixels of the second plurality of reconstructed blocks.

Abstract: Disclosed are techniques for compressing data of an image. Intermediate pixels may be determined. Each location of the image may be associated with a block of a plurality of blocks of a first size and a block of a plurality of blocks of a second size. For each block of the first size and of the second size, a first cost for a first mode and a second cost for a second mode may be determined in parallel using the intermediate pixels. A final mode and a final block size may be selected for each location of the image using the first cost and the second cost for each of a respective block of the first size and a respective block of the second size associated with a corresponding location. Final pixels may be determined, and a representation of the image may be obtained based on the final pixels.

Abstract: Disclosed are apparatuses, systems, and techniques for real-time codec encoding of video files using hardware-assisted accelerators that utilize a combination of parallel and sequential processing, in which at least a part of intra-frame block prediction is performed with parallel processing.

Abstract: A fastener tool which contains a motor, a drive mechanism connected to the motor and adapted to drive a piston, and a locking module. The locking module includes a rotating member coupled with the drive mechanism and adapted to rotate with a spindle and define a rotation axis; and a receiving member adapted to engage with the rotating member at and engaging portion. The rotating member includes a latch and a biasing member, wherein the biasing member moveably supports the latch in a direction substantially perpendicular to the rotation axis. Therefore, the locking module provides a locking mechanism that prevents back driving of the fastener tool that increases the lifespan and efficiency of the tool.

Abstract: A more efficient method of data collecting using multicast instead of individual slave-by-slave requests for data defines a multicast address through a master station. Slave stations are divided into feature groups according to their feature value and a mapping relationship table between the multicast addresses and the feature groups is established. Data request frames from the master station to the slave stations include a destination address which is parsed by all the slave stations, and if the destination address is the same as the multicast address in the mapping relationship table, the slave stations in the feature group associated with the destination address transmit data in response to the master station, the data request being discarded by other slave stations which are not associated.

Abstract: A bit rate control method includes the following operations: receiving a first target bit of a video to be coded; determining a second target bit for first coding tree units (CTUs) in CTUs of the video according to the first target bit; determining a fourth target bit of at least one fourth CTU in the CTUs according to an actual bit of at least one second CTU in the CTUs and a third target bit of at least one third CTU in the CTUs, in which the at least one second CTU is completely coded, the at least one third CTU is not completely coded, and a coding of the at least one fourth CTU is not started; and sequentially adjusting at least one coding parameter for coding the video according to the second target bit, the third target bit, and the fourth target bit.

Abstract: Methods of treating subjects with atopic dermatitis, e.g., associated with mutations in the TMEM79 gene, using Wnt inhibitors, e.g., porcupine inhibitors.

Abstract: A more efficient method of data collecting using multicast instead of individual slave-by-slave requests for data defines a multicast address through a master station. Slave stations are divided into feature groups according to their feature value and a mapping relationship table between the multicast addresses and the feature groups is established. Data request frames from the master station to the slave stations include a destination address which is parsed by all the slave stations, and if the destination address is the same as the multicast address in the mapping relationship table, the slave stations in the feature group associated with the destination address transmit data in response to the master station, the data request being discarded by other slave stations which are not associated.

Abstract: A computer-implemented method for training a deep neural network includes defining a loss function corresponding to the deep neural network, receiving a training dataset comprising training samples, and setting current parameter values to initial parameter values. An optimization method is performed which iteratively minimizes the loss function. During each iteration, a steepest direction of the loss function is calculated by determining the gradient of the loss function at the current parameter values. A batch of samples included in training samples is selected. A matrix-free CG solver is applied to obtain an inexact solution to a linear system defined by the steepest direction of the loss function and a stochastic Hessian matrix with respect to the batch of samples. A descent direction is determined, and the parameter values are updated based on the descent direction. Following the optimization method, the parameter values are stored in relationship to the deep neural network.

Abstract: A bit rate control method includes the following operations: receiving a first target bit of a video to be coded; determining a second target bit for first coding tree units (CTUs) in CTUs of the video according to the first target bit; determining a fourth target bit of at least one fourth CTU in the CTUs according to an actual bit of at least one second CTU in the CTUs and a third target bit of at least one third CTU in the CTUs, in which the at least one second CTU is completely coded, the at least one third CTU is completely coded, and a coding of the at least one fourth CTU is not started; and sequentially adjusting at least one coding parameter for coding the video according to the second target bit, the third target bit, and the fourth target bit.