Abstract: Exemplary embodiments include a sample collection device having a tube with an inner seal producing a sequestered lower compartment. In certain embodiments, the sequestered compartment may have a stabilizing reagent. The device may also have a cap suited towards the sample type being stored in the tube. In some cases, the cap may pierce the inner seal to allow a liquid sample to mix with the stabilizing reagent. In the case of liquid samples, a funnel may be used to aid in the deposition of the sample. In other cases, a swab or similar collection tool can be inserted into the tube, piercing the inner seal, and the cap will retain the swab in the cap. The device can be used for the collection of saliva, swab, or other samples at home without clinical supervision. The samples can be transported and stored for further analysis of the sample for DNA, RNA, or other biological components.

Abstract: A microfluidic assay device having a chemiluminescent testing assembly including a detection area, a sample inlet, and a microfluidic network including a first and second path extending to the detection area configured to capture a target analyte. When a fluid is provided to the sample inlet, a first portion of the fluid rehydrates a first dried reagent disposed along the first path to produce a first rehydrated reagent and a second portion of the fluid rehydrates a second dried reagent to produce a second rehydrated reagent. The first rehydrated reagent and the second rehydrated reagent are then sequentially delivered to the detection area by capillary-driven flow to perform the assay, where they react, optionally in the presence of a catalyst to form a chemiluminescent signal.

Abstract: A helmet is provided that can include a cage defining a front end, a back end opposite the front end, a first lateral end and a second lateral end opposite the first lateral end. The cage can include multiple longitudinal beams that extend between the back end of the cage and the front end of the cage; and a transverse beam that extends between the first lateral end of the cage and the second lateral end of the cage. The transverse beam can be anchored to the multiple longitudinal beams. The helmet can include a body that fully encapsulates the multiple longitudinal beams of the cage and that partially encapsulates the transverse beam. The body can define multiple vents. Each vent can be situated between two adjacent longitudinal beams. The transverse beam can extend through one of the multiple vents.

Abstract: Embodiments of the present disclosure disclose a method and a system for training a neural network for improving adversarial robustness. The method includes collecting a plurality of data samples comprising clean data samples and adversarial data samples. The training of the neural network includes training of a probabilistic encoder to encode the plurality of data samples into a probabilistic distribution over a latent space representation. In addition, the training of the neural network comprising training of a classifier to classify an instance of the latent space representation to produce a classification result. In addition, the method includes training shared parameters of a first instance of the neural network using the clean data samples and a second instance of the neural network using the adversarial data samples. Further, the method includes outputting the shared parameters of the first instance of the neural network and the second instance of the neural network.

Abstract: Disclosed are systems for applying materials to components. The system comprises a tool operable for transferring a portion of a material from a supply of the material to a component. A first portion of the tool may be configured for cutting along a side or edge of the portion of the material. A second portion of the tool may be configured for tamping, pressing, or pushing against the portion of the material to cause uncut sides or edges of the portion of the material attached to the supply of the material to be torn, severed, detached, or separated from the supply of the material.

Abstract: A three-phase load is powered by a PWM (e.g., SVPWM) driven DC-AC inverter having a single shunt-topology. A shunt voltage and a branch voltage of the inverter (across a transistor to be calibrated) are measured during a second period of each SVPWM sector, and the drain-to-source resistance of the calibrated transistor is calculated. During the fourth period of each SVPWM sector, the branch voltage is measured again, and another branch voltage across another transistor is measured. Using the drain-to-source resistance of the calibrated transistor and the voltage across the calibrated transistor measured during the fourth period, the phase current through the calibrated transistor is calculated. Using the other branch voltage measured during the fourth period and the drain-to-source resistance of its corresponding transistor (known from a prior SVPWM sector), the phase current through that transistor is calculated. From the two calculated phase currents, the other phase current can be calculated.

Abstract: Aspects of the invention provide a biological sample collection pad (e.g., for the collection of fecal, liquid or tissue samples). Method of using such pads and analyzing collected samples are also provided.

Abstract: Provided herein are aqueous compositions, kits and methods for the stabilization of cell-free nucleic acids. Provided herein are aqueous compositions for the stabilization of a cell-free nucleic acid (cfNA) population in a blood sample. In certain embodiments, the aqueous composition comprises a polyvinylpyrrolidone (PVP), an apoptosis inhibitor and one or more eryptosis inhibitors.

Abstract: Provided herein are devices and methods for sample isolation comprising a planar member configured to rotate around a bearing, and a plurality of apertures positioned at an angle to the planar member. Exemplary embodiments relate generally to the field of sample isolation, and more particularly to sample isolation using centrifugal and magnetic forces.

Abstract: A three-phase load is powered by a PWM (e.g., SVPWM) driven DC-AC inverter having a single shunt-topology. A shunt voltage and a branch voltage of the inverter (across a transistor to be calibrated) are measured during a second period of each SVPWM sector, and the drain-to-source resistance of the calibrated transistor is calculated. During the fourth period of each SVPWM sector, the branch voltage is measured again, and another branch voltage across another transistor is measured. Using the drain-to-source resistance of the calibrated transistor and the voltage across the calibrated transistor measured during the fourth period, the phase current through the calibrated transistor is calculated. Using the other branch voltage measured during the fourth period and the drain-to-source resistance of its corresponding transistor (known from a prior SVPWM sector), the phase current through that transistor is calculated. From the two calculated phase currents, the other phase current can be calculated.

Abstract: Solutions, reagents, and methods for nucleic acid purification. In certain aspects, cationic surfactant and, optionally, an anionic surfactant solutions are provided which can be used for phase separation and capture of nucleic acids, such as plasmid or genomic DNA, to a solid phase carrier, such as a mineral matrix.

Abstract: Solutions, reagents, and methods for nucleic acid purification. In certain aspects, cationic surfactant and, optionally, an anionic surfactant solutions are provided which can be used for phase separation and capture of nucleic acids, such as plasmid or genomic DNA, to a solid phase carrier, such as a mineral matrix.

Abstract: Disclosed are systems for applying materials to components. The system comprises a tool operable for transferring a portion of a material from a supply of the material to a component. A first portion of the tool may be configured for cutting along a side or edge of the portion of the material. A second portion of the tool may be configured for tamping, pressing, or pushing against the portion of the material to cause uncut sides or edges of the portion of the material attached to the supply of the material to be torn, severed, detached, or separated from the supply of the material.

Abstract: Disclosed are systems for applying materials to components. The system comprises a tool operable for transferring a portion of a material from a supply of the material to a component. A first portion of the tool may be configured for cutting along a side or edge of the portion of the material. A second portion of the tool may be configured for tamping, pressing, or pushing against the portion of the material to cause uncut sides or edges of the portion of the material attached to the supply of the material to be torn, severed, detached, or separated from the supply of the material.

Abstract: A three-phase load is powered by a PWM (e.g., SVPWM) driven DC-AC inverter having a single shunt-topology. A shunt voltage and a branch voltage of the inverter (across a transistor to be calibrated) are measured during a second period of each SVPWM sector, and the drain-to-source resistance of the calibrated transistor is calculated. During the fourth period of each SVPWM sector, the branch voltage is measured again, and another branch voltage across another transistor is measured. Using the drain-to-source resistance of the calibrated transistor and the voltage across the calibrated transistor measured during the fourth period, the phase current through the calibrated transistor is calculated. Using the other branch voltage measured during the fourth period and the drain-to-source resistance of its corresponding transistor (known from a prior SVPWM sector), the phase current through that transistor is calculated. From the two calculated phase currents, the other phase current can be calculated.

Abstract: A three-phase load is powered by a PWM (e.g., SVPWM) driven DC-AC inverter having a single shunt-topology. A shunt voltage and a branch voltage of the inverter (across a transistor to be calibrated) are measured during a second period of each SVPWM sector, and the drain-to-source resistance of the calibrated transistor is calculated. During the fourth period of each SVPWM sector, the branch voltage is measured again, and another branch voltage across another transistor is measured. Using the drain-to-source resistance of the calibrated transistor and the voltage across the calibrated transistor measured during the fourth period, the phase current through the calibrated transistor is calculated. Using the other branch voltage measured during the fourth period and the drain-to-source resistance of its corresponding transistor (known from a prior SVPWM sector), the phase current through that transistor is calculated. From the two calculated phase currents, the other phase current can be calculated.

Abstract: Methods are provided for determining a genomic methylation profile in a DNA sample. In certain aspects, the methods can be used to determine if a subject has, or is at risk for developing, a bladder cancer or other cancers of the urinary tract. Methods for treatment of such subjects are likewise provided.