Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: A mechanism is provided for enhancing security access to a data processing system. Responsive to authenticating a first factor of the multi-factor authentication by matching a scanned fingerprint/thumbprint of a user to at least one previously scanned fingerprint/thumbprint in a set of previously scanned fingerprints/thumbprints, a determination is made as to whether a touch pressure level exerted by the user on a touch pressure sensor associated with the data processing system matches at least one previously stored touch pressure level in a set of previously stored touch pressure levels. Responsive to matching the touch pressure level exerted by the user to a previously stored touch pressure level in the set of previously stored touch pressure levels, a second factor of the multi-factor authentication is authenticated. Access is then granted for the user to the data processing system.

Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: A display panel and a display device are provided. The display panel includes a substrate, signal lines located on the substrate, and a plurality of light-emitting elements each located on a side of one of the signal lines facing away from the substrate. Each light-emitting element includes a first electrode, a light-emitting layer, and a second electrode that are stacked sequentially. Each signal line includes at least one overlapping portion overlapping the light-emitting layer of one of the light-emitting elements in a direction perpendicular to the display panel. An angle ? between an extending direction of a part of the at least one overlapping portion and a pixel column direction in a display region that satisfies: 0°<?<90°, or an angle ? between an extending direction of a tangent of a part of the at least one overlapping portion and a pixel column direction in a display area that satisfies: 0°<?<90°.

Abstract: A method, system and computer program product for processing messages sent to a recipient. The communication channel used to send the message is identified, where such a communication channel is not currently being used by the recipient. After identifying the communication channel(s) currently being used by the recipient, the contact information of users who have previously communicated with the recipient using the communication channel(s) currently being used by the recipient are analyzed. The message is then marked with the identity of the sender as well as the communication channel used by the sender after matching the contact information of the sender with the contact information of a user who had previously communicated with the recipient using the communication channel(s) currently being used by the recipient. The marked message is then sent to the recipient using a communication channel currently being used by the recipient.

Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: A method, system and computer program product for processing messages sent to a recipient. The communication channel used to send the message is identified, where such a communication channel is not currently being used by the recipient. After identifying the communication channel(s) currently being used by the recipient, the contact information of users who have previously communicated with the recipient using the communication channel(s) currently being used by the recipient are analyzed. The message is then marked with the identity of the sender as well as the communication channel used by the sender after matching the contact information of the sender with the contact information of a user who had previously communicated with the recipient using the communication channel(s) currently being used by the recipient. The marked message is then sent to the recipient using a communication channel currently being used by the recipient.

Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.

Abstract: A method, system and computer program product for processing messages sent to a recipient. The communication channel used to send the message is identified, where such a communication channel is not currently being used by the recipient. After identifying the communication channel(s) currently being used by the recipient, the contact information of users who have previously communicated with the recipient using the communication channel(s) currently being used by the recipient are analyzed. The message is then marked with the identity of the sender as well as the communication channel used by the sender after matching the contact information of the sender with the contact information of a user who had previously communicated with the recipient using the communication channel(s) currently being used by the recipient. The marked message is then sent to the recipient using a communication channel currently being used by the recipient.

Abstract: Disclosed herein are technologies for a WYSIWYG user interface (UI) design tool that enables runtime behaviors (e.g., content update and user interaction) with UI controls during design time of such controls. That is, using a UI design tool in accordance with the technology described herein, the human designer can see and experience the runtime behavior of the UI controls while designing those controls. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: A mechanism is provided for enhancing security access to a data processing system. Responsive to authenticating a first factor of the multi-factor authentication by matching a scanned fingerprint/thumbprint of a user to at least one previously scanned fingerprint/thumbprint in a set of previously scanned fingerprints/thumbprints, a determination is made as to whether a touch pressure level exerted by the user on a touch pressure sensor associated with the data processing system matches at least one previously stored touch pressure level in a set of previously stored touch pressure levels. Responsive to matching the touch pressure level exerted by the user to a previously stored touch pressure level in the set of previously stored touch pressure levels, a second factor of the multi-factor authentication is authenticated. Access is then granted for the user to the data processing system.

Abstract: A method, system and computer program product for processing messages sent to a recipient. The communication channel used to send the message is identified, where such a communication channel is not currently being used by the recipient. After identifying the communication channel(s) currently being used by the recipient, the contact information of users who have previously communicated with the recipient using the communication channel(s) currently being used by the recipient are analyzed. The message is then marked with the identity of the sender as well as the communication channel used by the sender after matching the contact information of the sender with the contact information of a user who had previously communicated with the recipient using the communication channel(s) currently being used by the recipient. The marked message is then sent to the recipient using a communication channel currently being used by the recipient.

Abstract: Described herein is a technology for modifying hotspot objects in a user interface (UI). In one implementation, a view of a user interface is presented on a display by a hotspot manager. UI interaction including selection of a location in the view is received. A hotspot object associated to the selected location of the view may be modified based on the UI interaction when the hotspot manager is in an edit mode. The hotspot object contains information of the selected location. An updated content of the hotspot object may be presented in the edit mode, the updated content resulting from changes to an existing hotspot object or addition of a new hotspot object.

Abstract: Disclosed herein are technologies for a WYSIWYG user interface (UI) design tool that enables runtime behaviors (e.g., content update and user interaction) with UI controls during design time of such controls. That is, using a UI design tool in accordance with the technology described herein, the human designer can see and experience the runtime behavior of the UI controls while designing those controls. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: A lateral double diffusion metal-oxide-semiconductor (LDMOS) transistor is provided. The LDMOS transistor includes a semiconductor substrate having a well region and a drain region in the well region. The LDMOS transistor also includes at least one drifting region in the well region and an annular source region in the drifting region surrounding the drain region. Further, the LDMOS transistor includes at least one annular isolation structure surrounding the drain region in the drifting region. Further, the LDMOS transistor also includes an annular gate dielectric layer on the well region and an annular gate on the annular gate dielectric layer.

Abstract: Disclosed herein are technologies for a WYSIWYG user interface (UI) design tool that enables runtime behaviors (e.g., content update and user interaction) with UI controls during design time of such controls. That is, using a UI design tool in accordance with the technology described herein, the human designer can see and experience the runtime behavior of the UI controls while designing those controls. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: Described herein is a technology for modifying hotspot objects in a user interface (UI). In one implementation, a view of a user interface is presented on a display by a hotspot manager. UI interaction including selection of a location in the view is received. A hotspot object associated to the selected location of the view may be modified based on the UI interaction when the hotspot manager is in an edit mode. The hotspot object contains information of the selected location. An updated content of the hotspot object may be presented in the edit mode, the updated content resulting from changes to an existing hotspot object or addition of a new hotspot object.

Abstract: Described herein is a technology to dynamically generate a user interface (UI). In one implementation, a data source is analyzed to determine field information of the data source. UI controls are mapped to fields of the data source based on the field information to generate UI control mapping information. Based on the field information and the UI control mapping information, a layout may be generated. The layout may then be presented for preview.

Abstract: Disclosed herein are technologies for a WYSIWYG user interface (UI) design tool that enables runtime behaviors (e.g., content update and user interaction) with UI controls during design time of such controls. That is, using a UI design tool in accordance with the technology described herein, the human designer can see and experience the runtime behavior of the UI controls while designing those controls. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.