Abstract: Provided herein is a method of reprogramming a non-neuronal cell to a neuron. Aspects of the present disclosure relate to using cell reprogramming agent suppresses the expression or activity of PTB to convert a non-neuronal cell into a neuron. Also provided herein is a method of treating neurodegenerative disease by reprogramming non-neuronal cells in vivo to functional neurons.

Abstract: An electrical connector includes an insulative housing and a plurality of contacts retained within the housing as a contact module. The housing includes a base and a mating tongue forwardly extending from the base. The contacts are arranged with two rows contacting sections respectively exposed upon two opposite surfaces of the mating tongue, and one row mounting sections for mounting to a same plane of a printed circuit board. Each contact has a linking section between the contacting section and the mounting section. The contacts are grouped by one grounding contact associated with a pair of neighboring differential pair signal contacts in an isosceles triangular configuration wherein the grounding contact is located at the top apex. The linking section of grounding contact of the outermost group is widened compared with those of the remaining contacts for lowering the corresponding impedance.

Abstract: A femoral prosthesis and a knee prosthesis are provided. The femoral prosthesis includes a condyle surface having a first surface section contacting a tibial joint surface over a first range of flexion angles and a second surface section contacting the tibial joint surface over a second range of flexion angles; the first range of flexion angles from a first to a second flexion angle; the second range of flexion angles from the second to a third flexion angle; the first flexion angle selected from ?20° to 0°, the second flexion angle selected from 45° to 75°, the third flexion angle selected from 50° to 90° and the third flexion angle greater than the second flexion angle; the first surface section having a radius of curvature of a constant length, and the second surface section having a radius of curvature that decreases from a front end to the rear end.

Abstract: Backlight units include a light guide plate having a plurality of light extraction features, at least one light source optically coupled to a second major surface of the light guide plate, a rear reflector positioned proximate the second major surface, and a patterned reflective layer positioned proximate a first major surface of the light guide plate. Display and lighting devices comprising such backlight units are further disclosed.

Abstract: A knee prosthesis includes a tibial component, a bearing and a femoral component. The tibial component includes a platform and at least one rib extending upwardly and forwardly, a front edge of upper surface of the platform is provided with at least one front lug boss, and back edge of the upper surface of the platform is provide with at least one back lug boss. The lower surface of the bearing is provided with a groove matching with the at least one rib, a front slot matching with the front lug boss and a back slot; the femoral component is articulated with the bearing; at least one rib is provided with a medial wall and a lateral wall, one of the them is provided with a bent portion and formed with a first inclined surface which extends in a direction away from the other one.

Abstract: Reactive diluent fluid (22) is introduced into a stream of synthesis gas (or “syngas”) produced in a heat-generating unit such as a partial oxidation (“POX”) reactor (12) to cool the syngas and form a mixture of cooled syngas and reactive diluent fluid. Carbon dioxide and/or carbon components and/or hydrogen in the mixture of cooled syngas and reactive diluent fluid is reacted (26) with at least a portion of the reactive diluent fluid in the mixture to produce carbon monoxide-enriched and/or solid carbon depleted syngas which is fed into a secondary reformer unit (30) such as an enhanced heat transfer reformer in a heat exchange reformer process. An advantage of the invention is that problems with the mechanical integrity of the secondary unit arising from the high temperature of the syngas from the heat-generating unit are avoided.

Abstract: Embodiments of a deadfront article for a display are disclosed herein. The deadfront article includes a cover structure having: an inner surface; an outer surface opposite the inner surface; a glass layer located between the inner surface and the outer surface; and a first layer of light transmitting ink or pigment located between the inner surface of the cover structure and the glass layer. The deadfront article also includes a light guide layer having: an inner surface; and an outer surface facing toward the inner surface of the cover structure. A light extraction layer located on at least one of the inner surface and the outer surface of the light guide layer.

Abstract: An electrical connector with an insulative housing and a plurality of contacts retained thereto. The housing includes a base and a tongue extending forwardly from the base. Each first contact includes, along the front-to-back direction perpendicular to the transverse direction, a front first contacting section, exposed above a mating face of the tongue, a rear first soldering section extending out of the housing, and a first connecting section located therebetween wherein in the pair of first different contacts, the first connecting sections are transversely offset from the corresponding first contacting sections and toward each other so as to have therebetween a distance, in the transverse direction, smaller than that between the corresponding first contacting sections.

Abstract: A backlight unit suitable for use as an illuminator for liquid crystal display devices. The backlight unit comprises a glass light guide plate with a glass sheet including a first glass surface comprising a plurality of channels separated by peaks and arranged periodically therein, and a plurality of light emitting diodes arranged in an array along at least one edge surface of the glass sheet.

Abstract: An electrical connector includes an insulative housing and a plurality of contacts retained within the housing as a contact module. The housing includes a base and a mating tongue forwardly extending from the base. The contacts are arranged with two rows contacting sections respectively exposed upon two opposite surfaces of the mating tongue, and one row mounting sections for mounting to a same plane of a printed circuit board. Each contact has a linking section between the contacting section and the mounting section. The contacts are grouped by one grounding contact associated with a pair of neighboring differential pair signal contacts in an isosceles triangular configuration wherein the grounding contact is located at the top apex. The linking section of grounding contact of the outermost group is widened compared with those of the remaining contacts for lowering the corresponding impedance.

Abstract: A method of making a glass article, for example a glass light guide plate comprising at least one structured surface including a plurality of channels and peaks. The glass article may be suitable for enabling one dimensional dimming when used in a backlight unit for use as an illuminator for liquid crystal display devices.

Abstract: A memristor-reconstructed near-infrared SPR biosensor with adjustable penetration depth includes a prism unit, a first non-conductive dielectric film layer, a metal film layer, a second non-conductive dielectric film layer and a conductive dielectric film layer, wherein the prism unit is configured to generate an ATR (Attenuated Total Reflection) attenuation evanescent wave; the first non-conductive dielectric film layer, the metal film layer, and the second non-conductive dielectric iv film layer define a sensing unit for achieving a basic sensing function; the metal film layer, the second non-conductive dielectric film layer and the conductive dielectric film layer define a memristive unit; a voltage applying device is provided between the first electrode and the second electrode for applying a bias voltage to the memristive unit so as to realize infrared memristive reconfiguration.

Abstract: Reactive diluent fluid (22) is introduced into a stream of synthesis gas (or “syngas”) produced in a heat-generating unit such as a partial oxidation (“PDX”) reactor (12) to cool the syngas and form a mixture of cooled syngas and reactive diluent fluid. Carbon dioxide and/or carbon components and/or hydrogen in the mixture of cooled syngas and reactive diluent fluid is reacted (26) with at least a portion of the reactive diluent fluid in the mixture to produce carbon monoxide-enriched and/or solid carbon depleted syngas which is fed into a secondary reformer unit (30) such as an enhanced heat transfer reformer in a heat exchange reformer process. An advantage of the invention is that problems with the mechanical integrity of the secondary unit arising from the high temperature of the syngas from the heat-generating unit are avoided.

Abstract: Reactive diluent fluid (22) is introduced into a stream of synthesis gas (or “syngas”) produced in a heat-generating unit such as a partial oxidation (“POX”) reactor (12) to cool the syngas and form a mixture of cooled syngas and reactive diluent fluid. Carbon dioxide and/or carbon components and/or hydrogen in the mixture of cooled syngas and reactive diluent fluid is reacted (26) with at least a portion of the reactive diluent fluid in the mixture to produce carbon monoxide-enriched and/or solid carbon depleted syngas which is fed into a secondary reformer unit (30) such as an enhanced heat transfer reformer in a heat exchange reformer process. An advantage of the invention is that problems with the mechanical integrity of the secondary unit arising from the high temperature of the syngas from the heat-generating unit are avoided.

Abstract: Described herein, are cleansing compositions comprising a surfactant, phenoxyethanol, sodium salicylate, a polydentate chelating agent, and a structuring agent selected from: a gum and a polyacrylate.

Abstract: The invention provides compositions and in vivo, ex vivo and in vitro methods for trans-differentiation of or re-programming mammalian cells to functional neurons. In particular, the invention provides methods for engineering non-neuronal cells into neurons, including fully functional human neuronal cells, and methods for engineering non-neuronal cells into neurons, e.g., fully functional human neuronal cells, in the brain to treat a neurodegenerative disease. In alternative embodiments, the invention provides compositions comprising re-differentiated or re-programmed mammalian cells, such as human cells, of the invention. The invention also provides compositions and methods for direct reprogramming of cells to a second phenotype or differentiated phenotype, such as a neuron, including a fully functional human neuronal cell.

Abstract: An image sensor system, comprising: an image sensor including an image sensing pixel array; a supporting module; a ground line coupling the image sensor with the supporting module; a power line coupling the image sensor with the supporting module; a data/control line coupling the image sensor with the supporting module; and a clock line coupling the image sensor with the supporting module; wherein the ground line and the power line are based on electrical conduction, and wherein the clock line is based on fiber optics.

Abstract: The embodiment of the present disclosure relates to a system and a method for loading and unloading a cassette. The system comprises: a lifting device vertically moving between a first height and a second height; a first conveying device in the lifting device to move the cassette horizontally; a second conveying device to move the cassette in horizontally; a third conveying device to move the cassette horizontally, a plurality of first position sensors to detect a position of the lifting device; and a control device to control vertical movements of the lifting device, and adjust further movements of the first conveying device in the lifting device based on an initial stop position of the lifting device such that the first conveying device is aligned with the second conveying device at the first height, or is aligned with the third conveying device at the second height.

Abstract: A method to detect chromatin-interacting RNAs in any given state of a cell or tissue by examining global RNA interactions with DNA by deep sequencing. A method to generate a global view of chromatin-RNA interactome by mapping the binding locations on the genome of each detected chromatin interacting RNA.