Abstract: The road simulation device includes a frame structure and a transmission structure. The transmission structure includes a first test bench, a second test bench, a third test bench and a fourth test bench. A first sliding plate structure of the first test bench slides in a first direction and a second direction, a second sliding plate structure of the second test bench slides in the first direction, and a third sliding plate structure of the third test bench slides in the second direction. The first sliding plate structure and the first base structure, the second sliding plate structure and the second base structure, the third sliding plate structure and the third base structure, as well as the fourth baffle plate structure and the fourth base structure are connected by spherical hinges. Damages to the frame structure caused by huge acting force generated by rigid connection during testing can be avoided.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.

Abstract: CD73 (also known as ecto-5?-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I and pharmaceutically acceptable esters or salts thereof.

Abstract: Systems and methods for detecting, testing, and validating inactive paths or backup/protection paths of Label Switched Paths (LSPs) in a Multiprotocol Label Switching (MPLS) network are provided. A method, according to one implementation, includes the step of identifying an active path defining a traffic route along which data packets are transmitted from an ingress node to an egress node via one or more intermediate nodes. The method also includes sending an echo request from the ingress node to the one or more intermediate nodes, wherein the echo request allows the one or more intermediate nodes to detect and validate one or more inactive paths. The one or more inactive paths are configured as one or more protection paths when an event is detected that impedes the transmission of the data packets along the active path.

Abstract: Systems and methods for detecting, testing, and validating inactive paths or backup/protection paths of Label Switched Paths (LSPs) in a Multiprotocol Label Switching (MPLS) network are provided. A method, according to one implementation, includes the step of identifying an active path defining a traffic route along which data packets are transmitted from an ingress node to an egress node via one or more intermediate nodes. The method also includes sending an echo request from the ingress node to the one or more intermediate nodes, wherein the echo request allows the one or more intermediate nodes to detect and validate one or more inactive paths. The one or more inactive paths are configured as one or more protection paths when an event is detected that impedes the transmission of the data packets along the active path.

Abstract: Disclosed is a method for task planning of a space information network based on resource interchange. The method includes: initializing basic parameters of the space information network; dividing a planning horizon into K time slots of equal length, and constructing a resource time-varying graph for the space information network; sampling a feasible resource combination space of each task, and obtaining a candidate resource combination set comprised of the resource combinations with independence greater than or equal to a threshold n; calculating a conflict relation between resource combinations, and constructing a resource combination conflict graph; obtaining a maximum independent set of the resource combination conflict graph to obtain a global planning result; and searching a neighborhood of the global planning result, and completing a local adjustment of a task planning scheme through the resource interchange, to complete the task planning based on characteristics of the resource interchange.

Abstract: This patent provides a deadlock-free adaptive routing apparatus, method and computer storage medium for packets in two-dimensional mesh network based on the overlapping virtual network partitioning scheme, including: according to the offset between the source node and the destination node of the packet along the x-dimension or y-dimension, then use the x dimension and the y dimension to partition the two-dimensional mesh network into virtual networks; corresponding to each of the partitioned virtual networks, corresponding packet classes are respectively set, then merge virtual networks; based on the class the packet, inject the packet into the corresponding merged virtual network to route. This routing method balances utilization of the channels and improves efficiency of the data transmission.

Abstract: Systems and methods include receiving a traceroute packet at a relay node; responding to the traceroute packet with a first data structure inside the traceroute packet that indicates a propagation mode at the node and an operation type performed at the node, receiving subsequent traceroute packets from the initiator node with a second data structure inside the subsequent traceroute packets with data used to indicate changes in a header of the subsequent traceroute packets, and forwarding the subsequent traceroute packets with the changes to the header based on the data. The systems and methods can include utilizing the first data structure to determine the changes in the header of the subsequent traceroute packets. This can be used in Multiprotocol Label Switching (MPLS), Segment Routing (SR), and Internet Protocol (IP), where a TTL/Hop Limit propagation is limited.

Abstract: A method of preparing a cement hydration product nano-thin film, the method including: (1) preparing a cement hydration product; (2) preparing a water sacrificial layer film; (3) depositing the cement hydration product obtained in (1) on the surface of the water sacrificial layer film obtained in (2) to obtain a cement hydration product film; and (4) immersing the cement hydration product film in a saturated aqueous solution of calcium hydroxide to dissolve the water sacrificial layer film to obtain a nano-thin film of the cement hydration product.

Abstract: The present application relates to a method (I) for preparing a brivaracetam intermediate, comprising the steps of dissolving the compound represented by B-P and 1S,2S-diphenylethylenediamine in a solvent for resolution, crystallizing, filtering, and recrystallizing to obtain the compound represented by B-Q, which is then converted to the brivaracetam intermediate represented by B-R. This method can effectively resolve the compound represented by B-P. The present application also provides a method for preparing brivaracetam using the compound represented by B-R. The method can separate the effective components only through simple steps such as extraction, washing, drying, and concentration without requiring use of chiral chromatography column to separate isomers in the preparation process, and thus the separation process is simple, greatly reducing the production cost of brivaracetam.

Abstract: The present invention relates to a crystalline form of compound 3-((L-valyl)amino)-1-propanesulfonic acid, preparation method and uses thereof.

Abstract: There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.

Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.

Abstract: Systems and methods for a self-compressed YANG (Yet Another Next Generation) model allow a model data provider (e.g., a client that provides configuration information to a server, or a server that provides response data to a query) to dynamically select either text format or compressed format using the same data model. This approach can significantly increase the YANG management performance of both network elements and servers (e.g., Operations, Administration, and Maintenance (OAM) devices). The self-compressed YANG model maintains full compatibility to existing standards/implementations, namely, the enhanced compression is available where supported.

Abstract: Systems and methods for a self-compressed YANG (Yet Another Next Generation) model allow a model data provider (e.g., a client that provides configuration information to a server, or a server that provides response data to a query) to dynamically select either text format or compressed format using the same data model. This approach can significantly increase the YANG management performance of both network elements and servers (e.g., Operations, Administration, and Maintenance (OAM) devices). The self-compressed YANG model maintains full compatibility to existing standards/implementations, namely, the enhanced compression is available where supported.

Abstract: CD73 (also known as ecto-5?-nucleotidase) inhibitor compounds are provided, as well as compositions and uses thereof for treating or preventing CD73-associated or related diseases, disorders and conditions, including cancer- and immune-related disorders. CD73 inhibitor compounds include compounds having the structure set forth in Formula I and pharmaceutically acceptable esters or salts thereof.

Abstract: A space-saving lengthwise and widthwise movable panel system capable of being fully opened belongs to the field of smart building technology and includes a lengthwise panel moving compartment, a panel storage space and a panel control module. The movable panel system can be used as a door and/or window system. All of the panels of the system can be entirely stored in the panel storage space and when storing all of the panels entirely in the panel storage space, the panel system is fully open to allow full lengthwise access to a space. The panel storage space may be located in a wall or outside the room to hide the stacked panels. By controlling the operation of the moving system, the panels are effectively connected to one another in an aligned manner and can move automatically, so the space-saving movable panel system is convenient to use, and space-saving.

Abstract: A method of preparing a cement hydration product nano-thin film, the method including: (1) preparing a cement hydration product; (2) preparing a water sacrificial layer film; (3) depositing the cement hydration product obtained in (1) on the surface of the water sacrificial layer film obtained in (2) to obtain a cement hydration product film; and (4) immersing the cement hydration product film in a saturated aqueous solution of calcium hydroxide to dissolve the water sacrificial layer film to obtain a nano-thin film of the cement hydration product.

Abstract: A two-dimensional transition-metal dichalcogenide layer is grown by reacting a non- or low-volatile source material with a volatilized halogen or halide compound to produce a volatilized composition comprising at least one reaction product. The volatilized composition is flowed through an open chamber of a tube furnace with a temperature gradient, wherein the temperature changes along a path through which the volatilized composition flows through the open chamber of the tube furnace. Where the temperature along the path in the open chamber is in a reaction-temperature range, the volatilized composition is deposited as a two-dimensional crystalline transition-metal dichalcogenide layer.

Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.