Patents by Inventor Xiangqun Zeng
Xiangqun Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7888134Abstract: An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as Staphylococcus aureus having protein A or protein G.Type: GrantFiled: August 6, 2007Date of Patent: February 15, 2011Assignees: Oakland University, Vanderbilt UniversityInventors: Xiangqun Zeng, Raymond L. Mernaugh
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Patent number: 7886577Abstract: An ionic liquid bound on an exposed surface of a device such as for detecting organic chemicals, preferably a gas sensor is described. The gas sensor can operate at high temperatures with a fast linear response which is also reversible. At high temperatures, the frequency change (?f) versus concentration (C) curve mirrors the Henry's gas law, such that the concentration of a gas sample in liquid solvent is proportional to the concentration or partial pressure of the sample in gas phase. A single gas sensor, or an array of sensors, can be used for the detection and quantitative analysis of gas vapors.Type: GrantFiled: March 20, 2007Date of Patent: February 15, 2011Assignee: Oakland UniversityInventor: Xiangqun Zeng
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Publication number: 20100248283Abstract: A surface plasmon resonance biosensor device and system are provided. The simplicity of SPR biosensor design allows easy integration with both QCM and electrochemistry techniques, not found in current SPR biosensor devices. In some embodiments, the surface plasmon resonance biosensor device has a dual SPR/QCM sample holder which allows simultaneous detection by both surface plasmon resonance and also quartz crystal microbalance (QCM) techniques. In additional embodiments, the surface plasmon resonance biosensor device and/or the dual SPR/QCM technique can be integrated with electrochemistry techniques by incorporate reference and counter electrodes in the SPR or SPR/QCM sample holder. Methods of using the device and system to determine whether an analyte of interest is present in a sample are also provided.Type: ApplicationFiled: October 10, 2006Publication date: September 30, 2010Applicant: Oakland UniversityInventors: Caide Xiao, Xiangqun Zeng
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Publication number: 20090293590Abstract: An electrochemical piezoelectric sensor is disclosed. The sensor includes a piezoelectric substrate, three (or more) electrodes over a first surface of the substrate, and another electrode over a second (opposing) surface of the substrate. An ionic liquid in the form of a film is adhered, bound, immobilized, or otherwise positioned over the substrate and electrodes of the first surface. The ionic liquid film permits the absorption and detection of analytes from a gaseous sample, for environmental gases, example explosive vapors and/or explosive vapor species in the gaseous sample. Detection (optionally including analyte quantitation and qualitative identification) can be performed by both electrochemical and piezoelectric techniques using a single sensor. Systems incorporating and methods of using the electrochemical piezoelectric sensor also are disclosed.Type: ApplicationFiled: May 5, 2009Publication date: December 3, 2009Applicant: Oakland UniversityInventors: Xiangqun Zeng, Lei Yu, Yue Huang, Andrew J. Mason
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Patent number: 7464580Abstract: An ionic liquid piezoelectric gas sensor for the detection of polar and nonpolar organic vapors. The gas sensor can operate at high temperatures with a fast linear response which is also reversible. At high temperatures, the frequency change (?f) versus concentration (C) curve mirrors the Henry's gas law, such that the concentration of a gas sample in liquid solvent is proportional to the concentration or partial pressure of the sample in gas phase. The gas sensor can be used for quantitative analysis of gas vapors and determination of Henry constants.Type: GrantFiled: September 18, 2006Date of Patent: December 16, 2008Assignee: Oakland UniversityInventors: Xiangqun Zeng, Lei Yu, Rex Xiaofeng Ren
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Publication number: 20080193965Abstract: Methods of binding and detecting a microorganism on a solid substrate. The microorganism is bound on a solid substrate covalently bound to a capture agent having a saccharide moiety. A lectin capable of binding to the microorganism and the saccharide moiety of the capture agent is added to the sample to bind the microorganism on the solid substrate. Further provided are biosensor devices, such as a quartz crystal microbalance (QCM) device or a surface plasmon resonance (SPR) device, that incorporate the solid substrate for the detection of microorganisms.Type: ApplicationFiled: October 9, 2007Publication date: August 14, 2008Applicant: Oakland UniversityInventors: Xiangqun Zeng, Zhihong Shen
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Publication number: 20080171346Abstract: An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as Staphylococcus aureus having protein A or protein G.Type: ApplicationFiled: August 6, 2007Publication date: July 17, 2008Applicants: Oakland UniversityInventors: Xiangqun Zeng, Raymond L. Mernaugh
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Patent number: 7329536Abstract: An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time, is described. Each piezoelectric mass sensor comprises a piezoelectric crystal with a receptor surface which has immobilized thereon a lawn of recombinant antibodies comprising single VH chain or single-chain Fv (scFv) polypeptides specific for a particular antigen. Binding of antigen to the recombinant antibodies results in a change in mass on the receptor surface which is detected as a change in resonant frequency. In a preferred embodiment, the receptor layer is a precious metal such as gold which facilitates self-assembly of the recombinant antibodies into a lawn on the receptor surface via a cysteine residue at the carboxy terminus of the attachment polypeptide.Type: GrantFiled: June 4, 2004Date of Patent: February 12, 2008Assignees: Oakland University, Vanderbilt UniversityInventors: Xiangqun Zeng, Gabrielle Stryker, Raymond L. Mernaugh
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Publication number: 20070231918Abstract: An ionic liquid bound on an exposed surface of a device such as for detecting organic chemicals, preferably a gas sensor is described. The gas sensor can operate at high temperatures with a fast linear response which is also reversible. At high temperatures, the frequency change (?f) versus concentration (C) curve mirrors the Henry's gas law, such that the concentration of a gas sample in liquid solvent is proportional to the concentration or partial pressure of the sample in gas phase. A single gas sensor, or an array of sensors, can be used for the detection and quantitative analysis of gas vapors.Type: ApplicationFiled: March 20, 2007Publication date: October 4, 2007Applicant: Oakland UniversityInventor: Xiangqun Zeng
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Publication number: 20070068222Abstract: An ionic liquid piezoelectric gas sensor for the detection of polar and nonpolar organic vapors. The gas sensor can operate at high temperatures with a fast linear response which is also reversible. At high temperatures, the frequency change (?f) versus concentration (C) curve mirrors the Henry's gas law, such that the concentration of a gas sample in liquid solvent is proportional to the concentration or partial pressure of the sample in gas phase. The gas sensor can be used for quantitative analysis of gas vapors and determination of Henry constants.Type: ApplicationFiled: September 18, 2006Publication date: March 29, 2007Applicant: Oakland UniversityInventors: Xiangqun Zeng, Lei Yu
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Publication number: 20050003560Abstract: An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time, is described. Each piezoelectric mass sensor comprises a piezoelectric crystal with a receptor surface which has immobilized thereon a lawn of recombinant antibodies comprising single VH chain or single-chain Fv (scFv) polypeptides specific for a particular antigen. Binding of antigen to the recombinant antibodies results in a change in mass on the receptor surface which is detected as a change in resonant frequency. In a preferred embodiment, the receptor layer is a precious metal such as gold which facilitates self-assembly of the recombinant antibodies into a lawn on the receptor surface via a cysteine residue at the carboxy terminus of the attachment polypeptide.Type: ApplicationFiled: June 4, 2004Publication date: January 6, 2005Applicants: Oakland Univesity, Vanderbilt UniversityInventors: Xiangqun Zeng, Gabrielle Stryker, Raymond Mernaugh