Abstract: Anti-ACVR2A antibodies or antigen binding fragment thereof and uses thereof for inhibiting or antagonizing ACVR2A. The antibodies and antigen binding fragments may be used in therapeutic methods for treating ACVR2A or ACVR2A ligands associated diseases or disorders, which are ameliorated or improved by inhibition of ACVR2A.

Abstract: A binding molecule comprising a binding domain that binds to an antigen expressed on an activated hepatic stellate cells (HSC), and a functional domain that is capable of enhancing an antibody effector function such as antibody-dependent cell-mediated cytotoxicity (ADCC) toward activated HSCs. Uses of such binding molecule are also provided herein.

Abstract: A sport balance board includes an elastic layer, a supporting plate layer, and an anti-slip layer; the elastic layer and the anti-slip layer are positioned on opposite sides of the supporting plate layer, respectively; the supporting plate layer has an upper surface and a lower surface, the lower surface is a spherical or aspherical surface. The balance board of the present disclosure adopts an ergonomic design that enables users to naturally perform various swing and rotation actions while maintaining a good balance and stability, making the actions seem effortless and comfortable.

Abstract: An exercise board includes a main body and an elastic body configured on an upper surface of the main body. The upper surface of the main body is provided with at least one cavity, the cavity at least includes a first cavity part and a second cavity part, the first cavity part is located above the second cavity part, and a diameter of the first cavity part is less than that of the second cavity part. A lower surface of the elastic body is provided with at least one protrusion connected to the cavity, the protrusion at least includes a first protrusion part and a second protrusion part, the first protrusion part is located above the second protrusion part, and shapes of the first protrusion part and the second protrusion part match with shapes of the first cavity part and second cavity part.

Abstract: The present disclosure discloses an anti-fatigue mat and methods for making the same. The method for making an anti-fatigue mat includes providing a leather comprising a first surface and a second surface opposite to the first surface, forming a color layer on the first surface, cutting the leather, putting the cut leather into a mold, injecting an elastomeric material into the mold, curing the elastomeric material to form an elastic layer on the second surface and a plurality of concave structures corresponding to the plurality of protruding structures on the first surface, and polishing the first surface to remove the color layer without caving towards the second surface. The anti-fatigue mat can have anti-fatigue performance and vivid stereoscopic impression, where being simple to fabricate with low costs and can be industrialized.

Abstract: An exercise board includes a main body and an elastic body configured on an upper surface of the main body. The upper surface of the main body is provided with at least one cavity, the cavity at least includes a first cavity part and a second cavity part, the first cavity part is located above the second cavity part, and a diameter of the first cavity part is less than that of the second cavity part. A lower surface of the elastic body is provided with at least one protrusion connected to the cavity, the protrusion at least includes a first protrusion part and a second protrusion part, the first protrusion part is located above the second protrusion part, and shapes of the first protrusion part and the second protrusion part match with shapes of the first cavity part and second cavity part.

Abstract: The present invention provides an anti-slip cushioning sensor mat. The mat comprises a PVC leather layer, a polyurethane foaming layer disposed below the PVC leather layer, a sensitive layer disposed below the polyurethane foaming layer; and a rubber layer disposed below the sensitive layer. The sensitive layer further comprises a first flexible thin-film plate, a first conductive layer disposed below the first flexible thin-film plate, an intermediate layer disposed below the first conductive layer, a second conductive layer disposed below the intermediate layer. and a second flexible thin-film plate disposed below the second conductive layer. The present invention also provides an alarm system comprising the anti-slip cushioning sensor mat and a server, and a method for making the anti-slip cushioning sensor mat.

Abstract: The present invention provides an anti-slip cushioning sensor mat. The mat comprises a PVC leather layer, a polyurethane foaming layer disposed below the PVC leather layer, a sensitive layer disposed below the polyurethane foaming layer; and a rubber layer disposed below the sensitive layer. The sensitive layer further comprises a first flexible thin-film plate, a first conductive layer disposed below the first flexible thin-film plate, an intermediate layer disposed below the first conductive layer, a second conductive layer disposed below the intermediate layer. and a second flexible thin-film plate disposed below the second conductive layer. The present invention also provides an alarm system comprising the anti-slip cushioning sensor mat and a server, and a method for making the anti-slip cushioning sensor mat.

Abstract: The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.

Abstract: The present disclosure discloses an anti-fatigue mat and methods for making the same. The method for making an anti-fatigue mat includes providing a leather comprising a first surface and a second surface opposite to the first surface, forming a color layer on the first surface, cutting the leather, putting the cut leather into a mold, injecting an elastomeric material into the mold, curing the elastomeric material to form an elastic layer on the second surface and a plurality of concave structures corresponding to the plurality of protruding structures on the first surface, and polishing the first surface to remove the color layer without caving towards the second surface. The anti-fatigue mat can have anti-fatigue performance and vivid stereoscopic impression, where being simple to fabricate with low costs and can be industrialized.