Abstract: A method of pairing users for an uplink multi-user multiple-input-multiple-output (MU-MIMO) system under coordinated multipoint transmission (CoMP) scenario in a communication system, which includes: selecting, by a first cell of the communication system, at least one initial user served by the cell as a first paired user; selecting, by the first cell, a candidate paired user according to the service type of the first paired user; and determining, from the different service types of the first paired user and the candidate paired user, a pairing type to be formed, and determining whether the candidate paired user and the first paired user can be paired into the pairing type to be formed by using a predetermined determination criterion according to the pairing type. It is further provided a device for performing the method. The throughput and communication efficiency of the communication system can be improved with the method and device for pairing users.