Abstract: A compound containing a bis(azanylylidene) sulfonyl structure of formula (I) as a PKR agonist and/or USP9X inhibitor, which can be used for treating related diseases mediated and regulated by PKR and USP9X, wherein the related diseases comprise, but are not limited to: sickle-cell anemia, ?-thalassemia, hereditary non-spherocytic hemolytic anemia, hemolytic anemia, hereditary spherocytosis, hereditary elliptocytosis, abetalipoproteinemia, paroxysmal nocturnal hemoglobinuria, acquired hemolytic anemia, congenital anemia, anemia of chronic diseases, colorectal cancer, kidney cancer, pancreatic cancer, breast cancer, lung cancer, esophageal cancer, melanoma, lymphoma, glioblastoma, or multiple myeloma.

Abstract: Disclosed is a photodetector with a resonant waveguide structure, including: a substrate; a light absorption layer located on the substrate and configured for detecting an optical signal; a resonant waveguide structure including a first waveguide portion and a second waveguide portion spaced apart; the first waveguide portion receives the optical signal and transmits the received optical signal to a first region of the second waveguide portion, the second waveguide portion includes a second region for coupling the optical signal to the light absorption layer, and the second waveguide portion provides a circular transmission path for transmission of the optical signal to transmit the optical signal that transmitted to the first region to the second region along part of the circular transmission path and retransmit the optical signal that flows through the second region without being coupled to the light absorption layer to the second region along the circular transmission path.

Abstract: A method and apparatus for optimizing operation simulation of a data center are disclosed, and the method includes: constructing a data center simulation model; acquiring a state data set and an action data set of the data center; inputting the state data set and the action data set into a first state prediction model to obtain a next state data set; judging whether the next state data set meets a state safe judgment condition; if so, inputting the state data set and the action data set into a second state prediction model to obtain a next state data set; optimizing network parameters of a reinforcement learning algorithm; and determining an action data set corresponding to a real-time state data set of the data center by using the trained reinforcement learning algorithm.

Abstract: A device and a method to detect unauthorized opening of a casing is disposed in the upper or lower casing of an apparatus. The device includes a base plate with vibrator, carrier, and sensor on the lower case, and receiving grooves. Balls of a lesser number than the number of receiving grooves are installed in the grooves in a predetermined arrangement by the manufacturer. A waveguide element and magnet, fixed on the upper casing, is in contact with the balls, and when the waveguide is vibrated, the number and locations of the balls govern the form of a setting signal derived therefrom at the factory. If the upper casing is separated from the lower casing, the waveguide element separates from the carrier, the magnetic element gathers the balls, the predetermined arrangement being thereby lost, when tested by an authorized repair engineer.

Abstract: A system of determining a flight path for an aerial vehicle, includes a memory storing a program code, and a processor configured to execute the program code to identify, during a flight, an abnormal state occurring at a first location, in response to the abnormal state, control the aerial vehicle to fly along a first flight path from the first location to a first destination, after the aerial vehicle arrives at the first destination, evaluate a status of the aerial vehicle at the first destination to obtain an evaluation result, and based on the evaluation result, determine a second flight path of the aerial vehicle to a second destination. The first flight path is a reverse of a last flight path of the aerial vehicle before the aerial vehicle reaches the first location.

Abstract: The present disclosure provides an avalanche photodetector and a preparation method therefor.

Abstract: A device to detect unauthorized opening of a casing is disposed in the upper or lower casing of an apparatus. The device includes a base plate with vibrator, carrier, and sensor on the lower case, and receiving grooves. Balls of a lesser number than the number of receiving grooves are installed in the grooves in a predetermined arrangement by the manufacturer. A waveguide element and magnet, fixed on the upper casing, is in contact with the balls, and when the waveguide is vibrated, the number and locations of the balls govern the form of a setting signal derived therefrom at the factory. If the upper casing is separated from the lower casing, the waveguide element separates from the carrier, the magnetic element gathers the balls, the predetermined arrangement being thereby lost, when tested by an authorized repair engineer.

Abstract: Techniques are described with regard to container image configuration in a computing environment. An associated computer-implemented method includes initializing a container image storage engine associated with a logical tree structure having a plurality of container image nodes, where each of the plurality of container image nodes includes a hash layer array and a hash data array. The method includes building at least one new container image node to incorporate into the plurality of container image nodes. The method further includes applying a software patch to a target container image node among the plurality of container image nodes. In an embodiment, the method further includes starting at least one container based upon a respective container image node among the plurality of container image nodes.

Abstract: A one-hand control method for a touchscreen includes receiving a first input from a hand of a user on a first touch region; and performing target processing on a target object in a target interface based on a processing parameter corresponding to an input parameter of the first input, where the input parameter includes an input parameter for a holding part of the hand.

Abstract: The present disclosure provides a computer-implemented method, computer system and computer program product for data protection. According to the method, a first container may be created before an application container is ready for running. The first container is configured to: receive a first key from a key management device; obtain first encrypted data for the application container from a storage device; decrypt the first encrypted data using the first key to obtain first decrypted data; and mount the first decrypted data into the application container. The first container may be exited, and then the application container may be switched to ready for running.

Abstract: A system for simulating operation of a battery pack comprising a plurality of battery modules includes an electrical model configured to simulate electrical behavior of a respective battery module and a thermal model configured to simulate thermal behavior of the respective battery module. The electrical model provides outputs coupled as inputs to the thermal model, and the thermal model provides outputs coupled as inputs to the electrical model. A coolant model is configured to couple with the thermal model, the coolant model to simulate cooling of the respective battery module based on a temperature and a heat transfer coefficient associated with the respective battery module.

Abstract: Provided is a multifunctional high-frequency electric knife, comprising processing portion, sheath portion, and operating portion. The processing portion is provided with an electrode and a clip component; the electrode is provided with a hollow tubular portion; the electrode can be pushed out or retracted relative to far end of the sheath portion; the clip component can be pushed out or retracted relative to far end of the sheath portion; the sheath portion is disposed at near end of the processing portion and comprises a hollow pull rod and a spring tube; and the operating part is located at near end of the sheath portion and comprises a high-frequency joint connected to the electrode by wire, a component driving, by operating line, the electrode to move, a member driving the hollow pull rod to move, and a liquid inlet allowing liquid to flow to the hollow tubular portion of the electrode.

Abstract: Apparatuses, systems, and techniques to allocate processor memory. In at least one embodiment, an application programming interface is used to execute instructions to asynchronously allocate memory locations to processors.

Abstract: The present disclosure provides methods of controlling the size of cellulose crystals by mixing a first composition comprising cellulose and coagulating this mixture with varying concentrations of hydrogen peroxide.

Abstract: A compound of formula (I) capable of inhibiting plasmin activity, delaying fibrinolysis, and having coagulation and hemostatic activity, pharmaceutically acceptable salts, hydrates, isomers, prodrugs and mixtures thereof, wherein X, and R1 to R5 are as defined in the description.

Abstract: A gimbal servo control method includes obtaining a predicted flight trajectory of an aircraft within a preset time period from a current time, and adjusting an attitude of a gimbal carried by the aircraft according a predicted velocity direction of the aircraft at a point of the predicted flight trajectory.

Abstract: A composite aerogel based on graphdiyne motif arrangement and a preparation method thereof are provided by the embodiments of the disclosure, belonging to the technical field of photothermal evaporation materials, including firstly growing graphdiyne on a surface of the graphene oxide to obtain a graphdiyne-coated graphene oxide, taking an additional graphene oxide, adding the additional graphene oxide and the graphdiyne-coated graphene oxide obtained by the coupling reaction into pure water, and ultrasonically mixing to obtain a mixed dispersion, adding a polyvinyl alcohol aqueous solution into the mixed dispersion, and transferring to a reaction kettle after ultrasonic mixing, putting the reaction kettle after sealing into a blast drying box for hydrothermal reaction to obtain a gel structure, and cleaning the gel structure, and freeze-drying to obtain a composite aerogel containing graphdiyne-coated reduced graphene oxide and reduced graphene oxide.

Abstract: A method and apparatus for optimizing operation simulation of a data center are disclosed, and the method includes: constructing a data center simulation model; acquiring a state data set and an action data set of the data center; inputting the state data set and the action data set into a first state prediction model to obtain a next state data set; judging whether the next state data set meets a state safe judgment condition; if so, inputting the state data set and the action data set into a second state prediction model to obtain a next state data set; optimizing network parameters of a reinforcement learning algorithm; and determining an action data set corresponding to a real-time state data set of the data center by using the trained reinforcement learning algorithm.

Abstract: Computationally efficient and accurate methods of fitting black box simulation data to obtain Linear Parametrically Varying models useful for design of thermal management systems are disclosed. The Linear Parametrically Varying models may be used in dynamic simulations to determine temperatures in thermal systems. A computer-implemented model is run at a plurality of fixed values of the scheduling parameter to obtain output responses to excitations of the input at the fixed values of the scheduling parameter. LTI representations are fit to the output responses, the LTI representations having state-space variables characterized by negative real poles. Coefficient matrices of the LTI representations are updated, and an LPV-ROM representation is generated.