Patents by Inventor Xiaojun Zhao
Xiaojun Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12006310Abstract: The present invention relates to the technical field of natural medicines, and in particular to a triterpenoid compound with an effect of improving glucose and lipid metabolism disorders, and preparation and application thereof. A novel triterpenoid compound was obtained by separation from Momordica charantia L. for the first time in the present invention. Studies on a mouse primary hepatocyte model and a 3T3-L1 preadipocyte model show that the novel triterpenoid compound in the present invention has activity of regulating glucose and lipid metabolism, and after combination with known triterpenoid compound Momordicoside G, the activity of regulating glucose and lipid metabolism is significantly higher than that of a single compound at the same dose, indicating that the novel triterpenoid compound and a complex thereof in the present invention can be used to improve glucose and lipid metabolism disorders and provide a new way for diabetes treatment.Type: GrantFiled: July 1, 2022Date of Patent: June 11, 2024Assignee: SERICULTURAL & AGRI-FOOD RESEARCH INSTITUTE GUANGDONG ACADEMY OF AGRICULTERAL SCIENCESInventors: Mingwei Zhang, Yuanyuan Deng, Guang Liu, Yan Zhang, Zhencheng Wei, Pengfei Zhou, Ping Li, Zhihao Zhao, Xuchao Jia, Xiaojun Tang
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Patent number: 11992503Abstract: The present disclosure provides modified immune cells (e.g., modified T cells) comprising a chimeric antigen receptor (CAR) having affinity for a prostate-specific membrane antigen (PSMA) (e.g., human PSMA). The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor. The present disclosure provides modified immune cells (e.g., modified T cells) comprising a CAR having affinity for PSMA and a dominant negative receptor and/or a switch receptor, wherein the modified cell is capable of expressing and secreting a bispecific antibody.Type: GrantFiled: July 20, 2020Date of Patent: May 28, 2024Assignee: The Trustees of the University of PennsylvaniaInventors: Yangbing Zhao, Szu Hua Sharon Lin, Xiaojun Liu, Anne Chew
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Patent number: 11993626Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.Type: GrantFiled: December 13, 2022Date of Patent: May 28, 2024Assignee: Hongene Biotech CorporationInventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Aldrich N. K. Lau
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Patent number: 11993659Abstract: Disclosed herein are anti-BCMA antibodies and antigen-binding fragments, chimeric antigen receptors (“CARs”) having these anti-BCMA antibodies and antigen-binding fragments (“BCMA CARs”) and genetically modified immune effector cells having such BCMA CARs. Polynucleotides encoding the anti-BCMA antibodies and antigen-binding fragments and BCMA CARs are also provided herein. Compositions comprising anti-BCMA antibodies and antigen-binding fragments and BCMA CARs are also provided herein. The present disclosure also relates to use of the anti-BCMA antibodies and antigen-binding fragments and genetically modified immune effector cells having such BCMA CARs in cancer treatment.Type: GrantFiled: December 6, 2022Date of Patent: May 28, 2024Assignee: UTC THERAPEUTICS (SHANGHAI) CO., LTD.Inventors: Yangbing Zhao, Wei Pan, Xiaojun Liu
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Publication number: 20240156774Abstract: A composition containing a docetaxel albumin nanoparticle. The composition contains docetaxel and an acid-denatured albumin, wherein the acid-denatured albumin is obtained by means of adding an acid to human serum albumin to adjust the pH value. The composition can be prepared into an injection or a freeze-dried powder injection. A composition with satisfactory physical and chemical stability is obtained by means of controlling the content of sodium octanoate in human serum albumin, preferably in an acid denaturation condition.Type: ApplicationFiled: March 4, 2022Publication date: May 16, 2024Inventors: Chunlei LI, Xiaojun ZHANG, Yuanyuan ZHAO, Dongjian CHEN, Min LIANG, Qianbin XING, Nan LI, Yun SHU
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Publication number: 20240153257Abstract: A monitoring system based on a digital converter station includes a first monitoring terminal deployed at a first-level monitoring side, a second monitoring terminal deployed at a second-level monitoring side, and a third monitoring terminal deployed at a third-level monitoring side; the monitoring terminal at each level includes a communication module, a human-machine interaction module, a device status monitoring module, a device alarm management module, a video fusion processing module, and a data transmission adjustment and control module.Type: ApplicationFiled: January 11, 2024Publication date: May 9, 2024Applicants: STATE GRID CORPORATION OF CHINA, STATE GRID ECONOMIC AND TECHNOLOGICAL RESEARCH INSTITUTE CO., LTD, NR ELECTRIC CO., LTD., XJ GROUP CORPORATION, NARI TECHNOLOGY CO., LTD, BEIJING SGITG ACCENTURE INFORMATION TECHNOLOGY CENTER CO., LTD., HUAWEI TECHNOLOGY CO., LTDInventors: Wei JIN, Qing WANG, Xianshan GUO, Jun LYU, Siyuan LIU, Xiang ZHANG, Yanguo WANG, Zhanguo ZHANG, Haifeng WANG, Chong TONG, Ming LI, Wei CHENG, Ning ZHAO, Zhou CHEN, Xiaojun HOU, Hanqing ZHAO
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Patent number: 11979506Abstract: In a method for statistical analysis of aggregate encrypted data with key-leakage resilience for smart grids, every user area is managed by a fog node which plays the role of data aggregation gateway and data relay. All the users' electricity consumption data sent by smart meters in the same user area are firstly aggregated by the fog node to generate a fog-level aggregate ciphertext. Then the fog node further generates a digital signature for the fog-level aggregate ciphertext and sends these data to a cloud server for long-time storage. The cloud server stores all the aggregate ciphertexts and digital signatures received from different user areas in its database, and provides data query and statistical analysis services for the control center of smart grids. On the premise of without violating users' privacy, the cloud server could provide enough information for the control center, enabling it to compute the sum, arithmetic mean and variance of all users' data in specified areas in a privacy-preserving way.Type: GrantFiled: July 14, 2020Date of Patent: May 7, 2024Assignee: SOUTHWEST PETROLEUM UNIVERSITYInventors: Xiaojun Zhang, Chao Huang, Jingwei Zhang, Jie Gong, Ziyu Zhou, Shuang Zheng, Jie Zhao
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Patent number: 11959869Abstract: A method for monitoring mechanochemical activation of metal powders in dynamic electrochemical environment and a device thereof are provided. The method includes constructing a dynamic testing environment in an electrochemical cell, using a three-electrode system, and collecting data from an external electrochemical workstation. The three-electrode system is composed of the working metal plate, the reference electrode, and the platinum electrode. The dynamic testing environment includes small load impacts and changes in pH and composition of the solution. Under the premise of simulating the production environment of the mechanical plating and the water-based metal coating material, the monitoring method described in the present disclosure cooperates with an electrochemical workstation for OCPT testing to achieve the monitoring of mechanochemical activation of metal powders in dynamic electrochemical environment.Type: GrantFiled: September 8, 2023Date of Patent: April 16, 2024Assignee: Kunming University of Science and TechnologyInventors: Shengmin Wang, Chengyu Wang, Xiaojun Zhao, Peng Liu
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Publication number: 20240117362Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.Type: ApplicationFiled: August 16, 2023Publication date: April 11, 2024Inventors: Mufa Zou, David Yu, Aldrich N.K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
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Patent number: 11816443Abstract: The disclosure provides a method and an apparatus for generating a response, an electronic device, and a storage medium. The method includes: obtaining a current user request in a current conversation and historical coreference information in the current conversation; extracting content matching the current user request from the historical coreference information; updating the current user request based on the content to obtain an updated current user request; and generating a response of the current user request based on the updated current user request.Type: GrantFiled: July 22, 2021Date of Patent: November 14, 2023Assignee: BEIJING BAIDU NETCOM SCIENCE AND TECHNOLOGY CO., LTD.Inventors: Xiaojun Zhao, Meng Wang, Qingwei Huang
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Patent number: 11718782Abstract: A compound for use in oil recovery includes a quantum dot and a zwitterionic surfactant. The quantum dot has a diameter no greater than 25 nm and the quantum dot is bonded to the zwitterionic surfactant. A nanofluid for use in oil recovery includes the compound described above and a fluid carrier. A method for recovering oil from a formation includes flooding the formation with a nanofluid. The nanofluid has a quantum dot diameter no greater than 25 nm bonded to a zwitterionic surfactant and a fluid carrier.Type: GrantFiled: December 31, 2020Date of Patent: August 8, 2023Assignee: University of North DakotaInventors: Yanxia Zhou, Xu Wu, Julia Xiaojun Zhao, Hui Pu
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Patent number: 11355109Abstract: Embodiments of the present disclosure provide a method and apparatus for man-machine conversion, and an electronic device. The method includes: outputting question information to a user based on a first task of a first conversation scenario; judging, in response to receiving reply information returned by the user, whether to trigger a second conversation scenario based on the reply information; generating, in response to determining the second conversation scenario being triggered based on the reply information, response information corresponding to the reply information based on the second conversation scenario; and outputting the response information to the user.Type: GrantFiled: December 10, 2019Date of Patent: June 7, 2022Assignee: Beijing Baidu Netcom Science and Technology Co., Ltd.Inventors: Xuefeng Lou, Qingwei Huang, Weiwei Wang, Cheng Peng, Xiaojun Zhao
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Publication number: 20210350085Abstract: The disclosure provides a method and an apparatus for generating a response, an electronic device, and a storage medium. The method includes: obtaining a current user request in a current conversation and historical coreference information in the current conversation; extracting content matching the current user request from the historical coreference information; updating the current user request based on the content to obtain an updated current user request; and generating a response of the current user request based on the updated current user request.Type: ApplicationFiled: July 22, 2021Publication date: November 11, 2021Inventors: Xiaojun ZHAO, Meng Wang, Qingwei Huang
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Publication number: 20210269702Abstract: A compound for use in oil recovery includes a quantum dot and a zwitterionic surfactant. The quantum dot has a diameter no greater than 25 nm and the quantum dot is bonded to the zwitterionic surfactant. A nanofluid for use in oil recovery includes the compound described above and a fluid carrier. A method for recovering oil from a formation includes flooding the formation with a nanofluid. The nanofluid has a quantum dot diameter no greater than 25 nm bonded to a zwitterionic surfactant and a fluid carrier.Type: ApplicationFiled: December 31, 2020Publication date: September 2, 2021Inventors: Yanxia Zhou, Xu Wu, Julia Xiaojun Zhao, Hui Pu
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Publication number: 20210216594Abstract: A method and an apparatus are provided. The method may include: determining a service scenario based on a query sentence; entering the service scenario, and entering a first dialog node tree corresponding to the service scenario; storing, in response to determining that a common scenario needs to be entered based on a verification of a related parameter by the each parameter verification dialog node, the each parameter verification dialog node and jumping to the common scenario, and entering a second dialog node tree; collecting user information using the second dialog node tree, and in response to determining that the user information is collected successfully, determining whether a processing result of the second dialog node tree meets a backtracking condition; and returning to the service scenario based on the stored parameter verification dialog node and continuing to execute other dialog logic processing of the service scenario.Type: ApplicationFiled: March 29, 2021Publication date: July 15, 2021Inventors: Lianghuang FAN, Xuefeng LUO, Xiaojun Zhao, Xie HE, Changfu BAI
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Publication number: 20210216713Abstract: A method, an apparatus, a device and a storage medium for intelligent response are provided. The method may include: acquiring a current to-be-responded sentence, and determining a current to-be-collected entity corresponding to an intention of the current to-be-responded sentence; acquiring, if a pre-set entity clarification condition is met according to the current to-be-responded sentence, an entity clarification sentence corresponding to the current to-be-collected entity, where the entity clarification sentence is used to clarify an entity value of the current to-be-collected entity; and outputting the entity clarification sentence as a reply sentence of the current to-be-responded sentence.Type: ApplicationFiled: March 25, 2021Publication date: July 15, 2021Inventors: Xiaojun ZHAO, Xie HE, Xuefeng LUO, Lianghuang FAN, Changfu BAI
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Publication number: 20210214678Abstract: A method of making a porous three-dimensional graphene mesh includes combining a graphene-containing material and a polymer having a plurality of hydroxyl groups in an alcohol solvent to form a mixture, adding a salt to the mixture, heating the mixture to form a gel, and washing the gel with water to remove the salt from the gel, leaving behind stable pores to form a scaffold. A three-dimensional porous graphene mesh includes a graphene-containing material and a polymer. The polymer is crosslinked with the graphene-containing material such that the Young's Modulus of the mesh is at least about 5 GPa.Type: ApplicationFiled: March 26, 2021Publication date: July 15, 2021Applicant: University of North DakotaInventors: Ying Zhang, Julia Xiaojun Zhao, Diane Darland
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Patent number: 10988732Abstract: A method of making a porous three-dimensional graphene mesh includes combining a graphene-containing material and a polymer having a plurality of hydroxyl groups in an alcohol solvent to form a mixture, adding a salt to the mixture, heating the mixture to form a gel, and washing the gel with water to remove the salt from the gel, leaving behind stable pores to form a scaffold. A three-dimensional porous graphene mesh includes a graphene-containing material and a polymer. The polymer is crosslinked with the graphene-containing material such that the Young's Modulus of the mesh is at least about 5 GPa.Type: GrantFiled: January 28, 2020Date of Patent: April 27, 2021Assignee: University of North DakotaInventors: Ying Zhang, Julia Xiaojun Zhao, Diane Darland
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Publication number: 20200342868Abstract: Embodiments of the present disclosure provide a method and apparatus for man-machine conversion, and an electronic device. The method includes: outputting question information to a user based on a first task of a first conversation scenario; judging, in response to receiving reply information returned by the user, whether to trigger a second conversation scenario based on the reply information; generating, in response to determining the second conversation scenario being triggered based on the reply information, response information corresponding to the reply information based on the second conversation scenario; and outputting the response information to the user.Type: ApplicationFiled: December 10, 2019Publication date: October 29, 2020Inventors: Xuefeng Lou, Qingwei Huang, Weiwei Wang, Cheng Peng, Xiaojun Zhao
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Patent number: 10808220Abstract: A method of making a porous three-dimensional graphene mesh includes combining a graphene-containing material and a polymer having a plurality of hydroxyl groups in an alcohol solvent to form a mixture, adding a salt to the mixture, heating the mixture to form a gel, and washing the gel with water to remove the salt from the gel, leaving behind stable pores to form a scaffold. A three-dimensional porous graphene mesh includes a graphene-containing material and a polymer. The polymer is crosslinked with the graphene-containing material such that the Young's Modulus of the mesh is at least about 5 GPa.Type: GrantFiled: March 9, 2018Date of Patent: October 20, 2020Assignee: University of North DakotaInventors: Ying Zhang, Julia Xiaojun Zhao, Diane Darland