Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

Abstract: A computer-implemented method for searching in a database is provided according to one embodiment. The method includes, in response to receiving a search request to search in a database, extracting from the search request a condition for searching in the database. The method further includes selecting a search algorithm matching the condition from a plurality of search algorithms registered to the database, based on historical statistic data of historical search conducted on the database. Moreover, the method includes obtaining a search result from the database by using the search algorithm. The database is a time series database.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

Abstract: A computer-implemented method of processing a data query, includes in an edge device, processing a subquery of the data query, storing first statistical data on the subquery, and analyzing the first statistical data to optimize a parameter for processing subqueries.

Abstract: A heat dissipater having capillary component includes: a heat spreader including a shell member having at least one through hole and a first capillary structure disposed in the shell member; a heat pipe, received in the through hole and including a pipe member and a second capillary structure disposed in the pipe member. The pipe member includes an opening formed in the shell member; and a capillary component, accommodated in the shell member and including a block member extended with a protruding part and arranged adjacent to the first capillary structure. The protruding part is received in the opening and arranged adjacent to the second capillary structure. Accordingly, the heat pipe and the heat spreader can be combined for operation, and an internal working fluid can flow between the heat pipe and the heat spreader.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

Abstract: Antibodies to human GITR are provided, as well as uses thereof, e.g., in treatment of proliferative and immune disorders.

Abstract: Antibodies to human GITR are provided, as well as uses thereof, e.g., in treatment of proliferative and immune disorders.

Abstract: A computer-implemented method for searching in a database is provided according to one embodiment. The method includes, in response to receiving a search request to search in a database, extracting from the search request a condition for searching in the database. The method further includes selecting a search algorithm matching the condition from a plurality of search algorithms registered to the database, based on historical statistic data of historical search conducted on the database. Moreover, the method includes obtaining a search result from the database by using the search algorithm. The database is a time series database.

Abstract: Data processing device and method. The device includes: a spreadsheet of data displaying row for displaying a part of data retrieved from a database and a hyper row for expressing the remaining data; a data processor configured to calculate the value of the formula based on the data retrieved from the database. According to the device and method of the present invention, it is possible to eliminate overhead for loading data from the database to the spreadsheet when there are massive data records, continuously update the resulting data, and minimize users' development and migration cost.

Abstract: A heat dissipater having capillary component includes: a heat spreader including a shell member having at least one through hole and a first capillary structure disposed in the shell member; a heat pipe, received in the through hole and including a pipe member and a second capillary structure disposed in the pipe member. The pipe member includes an opening formed in the shell member; and a capillary component, accommodated in the shell member and including a block member extended with a protruding part and arranged adjacent to the first capillary structure. The protruding part is received in the opening and arranged adjacent to the second capillary structure. Accordingly, the heat pipe and the heat spreader can be combined for operation, and an internal working fluid can flow between the heat pipe and the heat spreader.

Abstract: The present disclosure relates to methods and systems for storing and querying data. According to the embodiments of the present invention, two-layer indexes are created for multi-dimension data, wherein the primary index is created based on two or more dimensions to retrieve respective data units of the data, while the secondary index is created based on specific dimensions to retrieve respective data blocks in the data unit. Correspondingly, when receiving a multi-dimension query request for data, the primary retrieval first determines a data unit including the target data based on a primary index, and then the secondary retrieval quickly locates a data block including the target data based on the secondary index. In this way, the multi-dimension retrieval can be efficiently performed. Moreover, by appropriately setting the size of a smallest data block, the I/O efficiency of data access will be significantly enhanced.

Abstract: A method for processing a time series includes dividing, with a processing device, the time series into a plurality of windows by time; extracting at least one group of similar subsequences from a current window among the plurality of windows; and updating a candidate list on the basis of comparison between similar subsequences in each group of the at least one group with k characteristic subsequences in the candidate list; wherein the k characteristic subsequences are k characteristic subsequences with a greatest number of occurrences in at least processed parts of the time series.

Abstract: The present disclosure relates to methods and systems for storing and querying data. According to the embodiments of the present invention, two-layer indexes are created for multi-dimension data, wherein the primary index is created based on two or more dimensions to retrieve respective data units of the data, while the secondary index is created based on specific dimensions to retrieve respective data blocks in the data unit. Correspondingly, when receiving a multi-dimension query request for data, the primary retrieval first determines a data unit including the target data based on a primary index, and then the secondary retrieval quickly locates a data block including the target data based on the secondary index. In this way, the multi-dimension retrieval can be efficiently performed. Moreover, by appropriately setting the size of a smallest data block, the I/O efficiency of data access will be significantly enhanced.

Abstract: A method for processing a time series includes dividing, with a processing device, the time series into a plurality of windows by time; extracting at least one group of similar subsequences from a current window among the plurality of windows; and updating a candidate list on the basis of comparison between similar subsequences in each group of the at least one group with k characteristic subsequences in the candidate list; wherein the k characteristic subsequences are k characteristic subsequences with a greatest number of occurrences in at least processed parts of the time series.

Abstract: Antibodies to human GITR are provided, as well as uses thereof, e.g., in treatment of proliferative and immune disorders.

Abstract: Embodiments of films and filters comprising nanoparticles, (e.g., in which each of a plurality of nanoparticles comprises a core surrounded by a ligand and/or where the diameter of each of at least some of nanoparticles is less than about 50 nm), and methods of making and using such films and filters.

Abstract: Antibodies to human GITR are provided, as well as uses thereof, e.g., in treatment of proliferative and immune disorders.

Abstract: Antibodies to human GITR are provided, as well as uses thereof, e.g., in treatment of proliferative and immune disorders.

Abstract: An electrical connector includes an insulative housing, a number of electrical contacts and an IC (Integral Circuit). The insulative housing has a body and a contact insert received in the body. The electrical contacts are secured to the contact insert and each has a mating end, a solder end projecting out of the insulative housing and a connecting end located therebetween. The IC is bonded to contact insert for electrical connecting with the connecting ends of the electrical contacts, respectively.