Abstract: The present disclosure provides TrkA antibodies, compositions comprising such antibodies, and methods of using such antibodies for the prevention and/or treatment of a disease or disorder associated with an inappropriate expression or function of TrkA, such as pain.

Abstract: A light source module includes a blue light generation portion, a cyan light generation portion, a yellow-green light generation portion and a red light generation portion. The red light generation portion includes a first additional light emitter and a second additional light emitter, the first additional light emitter emits a light having a main emission peak in the red light wave band, the second additional light emitter emits a light having a secondary emission peak in the red light wave band, and a spectral intensity of the secondary emission peak is 30.0%-80.0% of a spectral intensity of the main emission peak. An emitted light of the light source module is a white light with a color temperature of 3000K˜6000K, and in a CIE1931 color space, a distance between the emitted light and a blackbody locus BBL is duv=?0.007-0.007.

Abstract: The present invention discloses a nucleic acid detection kit and a detection method based on photo-controlled CRISPR-Cas, wherein the kit comprises silent guide RNA and Cas protein; the silent guide RNA is formed by annealing hybridization of silent nucleotide and guide RNA; the guide RNA, designed according to a target nucleic acid sequence, includes two regions, i.e. a repetitive region and a spacer region; the silent nucleotide is completely complementarily paired with a the of the guide RNA, or is completely paired with a the of the guide RNA; the bases of the silent nucleotide are linked by PC linker; and the Cas protein is Cas12 protein or Cas13 protein. Although this method separates the nucleic acid amplification from the CRISPR-Cas detection in time, it can allow them to be completed in the same closed reaction tube, thereby avoiding the transfer process of uncapped reagent, ensuring that the detection is not affected by aerosol pollution while ensuring high detection sensitivity.

Abstract: Disclosed are a method for generating a high-precision road map, a high-precision road map generation device, equipment and a storage medium. The method includes: based on a constant temperature control system, collecting a plurality of road information to be processed by different sensors, so that the different sensors can all operate at a suitable temperature and are not affected by the environment; performing feature extraction on the plurality of the road information to be processed, and obtaining road feature information; and connecting a mileage meter by a vehicle controller area network port or a related domain controller to obtain mileage information of the vehicle and posture control information of the vehicle, and predicting the posture of the vehicle to provide auxiliary information for an inertial system, and finally generating a high-precision road map according to the road feature information, vehicle body posture control information of a vehicle and mileage information.

Abstract: Disclosed are an aroyl substituted tricyclic compound, a preparation method therefor and use thereof. Specifically, the aroyl substituted tricyclic compound of the present invention has a structure of formula (C), and has, as a BTK inhibitor, the advantages of high activity, good selectivity and low toxic and side effects.

Abstract: This application belongs to the field of optical cables and provides a reinforced protection micro-bunched cable and a manufacturing process thereof. The reinforced protection micro-bunched cable includes reinforced protection micro-bunched tubes; the outer surface of the reinforced protection micro-bunched tube is arranged with bumps and there is a gap between bumps. The thickness of the micro-bunched tube wall at the gap between the bumps is still small, and the bump material is softer than the tube body material. The thickness of the micro-bunched tube wall at the gap between the bumps is still small, which can meet the construction requirements of easiness for stripping; the bump can effectively buffer the external force; further, the added bumps can increase the longitudinal tensile properties of the whole tube, and the tube was not easy to be broken under tension.

Abstract: A unidirectional stranded micro-bundle optical cable and a manufacturing process thereof, where the unidirectional stranded micro-bundle optical cable provided by the present disclosure includes micro-bundle tubes, a reinforcing layer, a water-blocking tape and an outer sheath; a first water-blocking yarn is arranged between the micro-bundle tubes, a tearing rope is arranged in the water-blocking tape, and a reinforcing member is arranged in the outer sheath; the micro-bundle tubes adopt a spiral stranding with a stranding mode of unidirectional stranding and a stranding pitch of 800 mm to 900 mm; the reinforcing layer adopts a spiral stranding with a stranding mode of unidirectional stranding and a stranding pitch of 600 mm to 800 mm; a stranding direction of the micro-bundle tube is opposite to a stranding direction of the reinforcing layer.

Abstract: This application discloses a cache management method, apparatus, and system, and a storage medium, and belongs to the computer field. The system includes a processor and a memory controller. The processor and the memory controller are connected through a first channel and a second channel, the first channel is used to perform a memory read/write operation, and the second channel is used to transmit event information corresponding to the memory read/write operation. The processor is configured to send event information of a first event to the memory controller through the second channel. The memory controller is configured to manage a cache storage based on the event information, and the cache storage is configured to cache a part of data that is in the memory storage. This application can improve utilization of the cache storage.

Abstract: Provided an automatic feeding device for automotive wheel hub, comprising a separable material rack having material rack units capable of being stacked in turn, a first roller table for conveying the separable material rack containing the wheel hub to a second roller table, and a material rack separating device having a support frame and material rack inserting and taking devices; the second roller table, under which a lifting platform is mounted, is located at a first end of lower part of the material rack inserting and taking device; the material rack inserting and taking device splitting the separable material rack into units, and placing to a third roller table being arranged at a second end of the lower part thereof; a manipulator, for grasping and placing the wheel hub from the material rack unit to a fourth roller table being on a second side thereof.

Abstract: An image acquisition method includes importing a three-dimensional model of an object into a three-dimensional virtual photographing scene having a virtual world coordinate system, determining model position information and model attitude information of the three-dimensional model in the virtual world coordinate system, determining, according to a layout pattern of a plurality of virtual cameras in the three-dimensional virtual photographing scene, camera position information and camera attitude information of each of the plurality of virtual cameras in the virtual world coordinate system, and acquiring, for each of the plurality of virtual cameras, an image of the object from a viewing angle of the virtual camera according to the model position information, the model attitude information, the camera position information, and the camera attitude information.

Abstract: Disclosed is a heterocyclic lactam compound or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, as represented in formula (I), wherein the compounds have an inhibitory effect on RIPK1 and the definition of each group in the formula is detailed in the description. In addition, further disclosed are a pharmaceutical composition containing the compound, and the use thereof in the preparation of a drug for treating RIPK1-related diseases or conditions.

Abstract: The present disclosure provides TrkA antibodies, compositions comprising such antibodies, and methods of using such antibodies for the prevention and/or treatment of a disease or disorder associated with an inappropriate expression or function of TrkA, such as pain.

Abstract: A trusted anonymous voting method includes: performing a hash operation on original voting content to obtain a hash output including a commitment value cvi; blinding the commitment value cvi based on information of other voters to obtain commitment value tuples {tilde over (c)} and {tilde over (x)}; signing the commitment value tuple {tilde over (c)} by using an ESDSA to obtain a signature tuple {tilde over (s)}; and establishing a vote tuple ({tilde over (c)}, {tilde over (s)}, {tilde over (d)}) based on the commitment value tuple {tilde over (c)}, the signature tuple {tilde over (s)} and a signature tuple {acute over (d)} of other voters, and uploading the vote tuple (?, ?, {acute over (d)}) and the commitment value tuple {tilde over (x)} to the blockchain, where signature tuple {tilde over (d)} is generated in a case that other voters verify the signature tuple {tilde over (s)} and the signature tuple {tilde over (s)} passes the verification, and the commitment value tuple {tilde over (x)} is used to decry

Abstract: Provided is a pyridino- or pyrimido-cyclic compound having an inhibitory effect on a KRAS gene mutation, or a pharmaceutically acceptable salt, a stereoisomer or a solvate thereof, wherein the structure of the compound is as shown in formula (AI) or (AII), and the definition of each group in the formula is detailed in the description. In addition, also disclosed are a pharmaceutical composition comprising the compound, and the use thereof in the preparation of a cancer drug.

Abstract: Techniques for code modification for detecting abnormal activity are described. Web code is obtained. Modified web code is generated by changing a particular programmatic element to a modified programmatic element throughout the web code. Instrumentation code is generated configured to monitor and report on one or more interactions with versions of the particular programmatic element. The instrumentation code is caused to be provided in association with the modified web code to the first client device in response to the first request from the first client device. Report data generated by the instrumentation code is received. The report data describes abnormal activity at the first client device, the abnormal activity comprising an interaction with a version of the particular programmatic element that does not exist in the modified web code. Based on the report, it is determined that the first client device is likely controlled by malware.

Abstract: A timestamp generation method and apparatus, and an electronic device and a storage medium, which are used for solving the technical problem of recorded information being easily leaked because a trusted third party is usually needed as a timestamp authority for recording in a traditional trusted timestamp generation method. In the present invention, the method comprises: acquiring a file record; calculating a hash value of the file record; sending the hash value to a random issuer, and receiving a signature result returned by the random issuer, wherein the signature result is generated after the random issuer signs the hash value and a receiving time, and the receiving time is the time when the random issuer receives the hash value; and storing the signature result in a blockchain as a timestamp of the file record.

Abstract: An image noise reduction method including: obtaining a first image to be processed and a second image as a reference image; obtaining a block of the first image by dividing the first image; determining a motion intensity of the block based on the second image; obtaining filter coefficient description information matching the motion intensity based on: a first pixel difference of a first pixel point value of the first image and a second pixel point value of the second image, and a filter coefficient; obtaining a target pixel difference between a third pixel point value of the block and a fourth pixel point value of the second image; determining a target filter coefficient corresponding to the target pixel difference based on the filter coefficient description information; and determining a target noise reduction image of the first image based on the target filter coefficient.

Abstract: A video frame processing method, performed by a computer device, includes: receiving video frames carrying noise, wherein the video frames include an object; extracting poses of a part of the object; determining deflection degree values of the part based on the poses; generating a control signal based on the deflection degree values; obtaining updated deflection values based on backlash filtering of the control signal; and performing image processing on the video frames based on the updated deflection values.

Abstract: The invention provides method, device, and system to commission medical devices using different wireless communication protocol or from different manufacturers to a network by introducing a pairing device and a guiding device. The commissioning process includes two steps, e.g., a pairing the medical device to the pairing device and a pairing between the pairing device and server of the network. By configuring a pairing device dynamically with the aid of a guiding device, the pairing device can receive broadcast messages from medical devices using different communication protocols and send the same to a remote server having a specific network address. Further, the guiding device is introduced not only to assist in the configuration of the pairing device, but also provide an opportunity to the pairing device to obtain a real-time feedback from the remote server through the guiding device during installation.

Abstract: Systems and methods for generating an entity classification model using text classification of raw text information of entities are described. Generating the classification model includes obtaining raw text information associated with a plurality of entities, converting the raw text information for each entity of the plurality of entities into one or more character strings, generating a numerical vector for each entity of the plurality of entities based on the one or more character strings for each entity, and selecting, based on the numerical vectors for each entity of the plurality of entities, one or more entity properties to be used for entity classification. A classification of a first entity coupled to a network is performed based on the one or more selected entity properties.