Abstract: The disclosure provides compositions and methods for the Vectored Augmentation of the Destruction, Expression and/or Regulation of proteins, e.g., VA-DER systems and methods.

Abstract: Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of anemia.

Abstract: The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: An electrical connector includes an insulating body and first through eighth terminals sequentially arranged in a lateral direction in the insulating body, wherein the first and second terminals, the third and sixth terminals, the fourth and fifth terminals, and the seventh and eighth terminals are respectively used to transmit a pair of differential signals, each terminal including: a mating portion for mating to a mating connector; a tail portion opposite to the mating portion; and a connecting portion connected therebetween, the connecting portions of the third terminal to the fifth terminal are all provided with a coupling portion; wherein the coupling portions of the third through fifth terminals are in three different planes, respectively, and the coupling portion of the fifth terminal and the coupling portion of the third terminal at least partially overlap in a longitudinal direction perpendicular to the lateral direction.

Abstract: An electrical connector includes a terminal module having a circuit board having first through eighth conductive traces sequentially arranged in a transverse direction and corresponding first through eighth terminals, the third terminal and the sixth terminal being configured for transmitting a pair of differential signals, the fourth terminal and the fifth terminal being configured for transmitting another pair of differential signals, the first through eighth conductive traces being respectively electrically connected to corresponding first through eighth terminals, each of the third conductive trace and the fifth conductive trace including a coupling portion, a size of the coupling portion in the transverse direction is larger than a size of the other part of the corresponding conductive trace in the transverse direction, wherein the coupling portion of the third conductive trace and the coupling portion of the fifth conductive trace overlap in an up and down direction to increase mutual coupling.

Abstract: An air leak detection device, air leak detection method and system thereof are provided. The air leak detection method is used for a cavity. The air leak detection method includes the following steps. A scanning signal is input into the cavity. A response signal of the cavity related to the scanning signal is recorded. The response signal is analyzed to determine whether the cavity is air leaking.

Abstract: A speaker includes a frame, a vibration assembly and a magnetic circuit assembly. The vibration assembly is assembled on the frame. The magnetic circuit assembly is assembled on the frame. The vibration assembly includes a voice coil and a piezoelectric element, the voice coil and the piezoelectric element are arranged coaxially, and the voice coil is between the piezoelectric element and the magnetic circuit assembly.

Abstract: A high pitch enhanced passive radiator is adapted to be utilized in a passive radiator speaker. The high pitch enhanced passive radiator includes a shell, a woofer, and the passive radiator speaker. The shell has a first slot and a second slot. The woofer is connected to the first slot. The passive radiator speaker is connected to the second slot and includes a flange, a piezoelectric speaker, and a counterweight plate. The piezoelectric speaker is connected to the flange. The projected area of the counterweight plate and the projected area of the piezoelectric speaker at least partially overlap with each other.

Abstract: A combustion pre-chamber assembly includes pre-chamber device body defining an annular plenum that is in fluid communication with the at least one bore that extends through the spark plug shell. The annular plenum is also in communication with at least one purging passage that extends from the annular plenum to an end surface of the pre-chamber device body. Residual exhaust gases in the annular volume of the spark plug are purged by fresh charge flow from the main combustion chamber as the piston approaches top dead center. The fresh charge flow that is provided to the annular plenum through the at least one purging passage and into the annular volume of the spark plug through the at least one bore through the spark plug shell.

Abstract: An information display method, terminal, and server, where the method includes obtaining, by a terminal, content information of at least one content source, where the at least one content source corresponds to at least two pieces of account information stored in the terminal, integrating, by the terminal, the content information into content display information, and displaying, by the terminal, the content display information. Content information of a content source is obtained, integrated, and then displayed to a user by classification, so that it is concise and intuitive for the user to query information without cumbersomeness.

Abstract: The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.

Abstract: The present invention relates to adeno-associated viral (AAV) particles modulatory polynucleotides encoding at least one siRNA molecules and methods of use thereof.

Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.

Abstract: A combustion pre-chamber device for a spark ignition internal combustion engine is configured to engage a spark plug and be mounted to a cylinder head in communication with a combustion chamber of a cylinder of the engine. The combustion pre-chamber device includes any one or combination of a number of features to improve operating effectiveness, including extending the combustion operating range by improving cooling and optimizing the flow field inside the combustion pre-chamber device.

Abstract: A knowledge graph embedding method, system, and computer program product using a computing device to embed a knowledge graph using a graph convolutional network, the method including learning, by the computing device, an embedding of the knowledge graph that includes entities, relations, and edges, weighing, by the computing device, initial feature vectors of nodes and a convolutional layer output to compute a weight and modifying the embedding based on the weight, and using, by the computing device, the modified embedding to perform a task related to the knowledge graph.

Abstract: A graph neural network (GNN) training method, system, and computer program product in a graph, include generating, by the computing device, one or more one or more hypothetical edges between two or more nodes of a plurality of nodes of a graph neural network, testing, by the computing device, to determine whether the one or more generated hypothetical edges should be connected by using negative sampling, and permanently connecting, by the computing device, the one or more tested hypothetical edges if the negative sampling indicates the connectivity.

Abstract: An electrical connector includes an insulating body and first through eighth terminals sequentially arranged in a lateral direction in the insulating body, wherein the first and second terminals, the third and sixth terminals, the fourth and fifth terminals, and the seventh and eighth terminals are respectively used to transmit a pair of differential signals, each terminal including: a mating portion for mating to a mating connector; a tail portion opposite to the mating portion; and a connecting portion connected therebetween, the connecting portions of the third terminal to the fifth terminal are all provided with a coupling portion; wherein the coupling portions of the third through fifth terminals are in three different planes, respectively, and the coupling portion of the fifth terminal and the coupling portion of the third terminal at least partially overlap in a longitudinal direction perpendicular to the lateral direction.

Abstract: Provided are a computer-implemented method, system, and computer program product for multidimensional data recover. A snapshot restore request is received with at least one parameter defining at least one dimension for data recovery. At least one snapshot is reconstructed from a single continuous snapshot stream taken for a certain period of time based on the at least one parameter. A selected snapshot is received for data recovery selected from the at least one reconstructed snapshot. The selected snapshot is restored.

Abstract: An electrical connector includes a terminal module having a circuit board having first through eighth conductive traces sequentially arranged in a transverse direction and corresponding first through eighth terminals, the third terminal and the sixth terminal being configured for transmitting a pair of differential signals, the fourth terminal and the fifth terminal being configured for transmitting another pair of differential signals, the first through eighth conductive traces being respectively electrically connected to corresponding first through eighth terminals, each of the third conductive trace and the fifth conductive trace including a coupling portion, a size of the coupling portion in the transverse direction is larger than a size of the other part of the corresponding conductive trace in the transverse direction, wherein the coupling portion of the third conductive trace and the coupling portion of the fifth conductive trace overlap in an up and down direction to increase mutual coupling.

Abstract: A method, a computer program product, and a system for non-obvious relationship detection. The method includes receiving a knowledge and inputting a first node and a second node from the knowledge graph into a twin neural network. The method also includes embedding the first node and the second node, aggregating neighborhood information and position information into the node embeddings. The method further includes concatenating the neighborhood information and the position information of the first node and the second node to produce a first output vector and a second output vector. The method also includes generating a final score by comparing the first output vector with the second output vector. The final score indicates a probability of a non-obvious relationship between the first node and the second node.