Abstract: A machine learning method predicts whether a specified subject is at high risk of developing cognitive impairment based upon a data record for said specified subject, and a method of training a dual neural network for such. These methods may work by automatically classifying said subject into a first class associated with a first predicted risk of cognitive impairment or a second class associated with a second predicted risk of cognitive impairment. Subject records are obtained comprising a first set of measured data and a second set of data including results for two or more health assessment questionnaires; and a label indicating that the subject belongs to the first class or second class. These records are used to train first and second neural networks, and in the latter method these trained networks are able to predict whether a specified subject should belong to said first class or second class.

Abstract: The present invention relates to a thin-film composite (TFC) membrane composition comprising macrocycles. The invention also relates in part to a method of fabricating a TFC membrane and to a method of using the TFC membrane to separate a desired liquid or gas from a liquid or gas mixture.

Abstract: This application relates to a galvanometer-based laser synchronization controlling method, calibration method and apparatus, and a LiDAR. The galvanometer-based laser synchronization controlling method includes obtaining a fast-axis feedback signal when a galvanometer scans; obtaining a first phase difference between a fast-axis drive signal and the fast-axis feedback signal and obtaining a second phase difference between an emission period of a laser beam and the fast-axis drive signal; and setting a phase for the fast-axis drive signal based on the first phase difference and the second phase difference.

Abstract: The present disclosure describes membrane compositions and methods for preparing membrane compositions. In particular, the methods employ a layer-by-layer approach to membrane preparation. The membrane compositions provide significantly enhanced membrane performance over existing commercial membranes, particularly in terms of permeability and selectivity.

Abstract: The disclosure relates to an expression method of a Haemocoagulase Acutus (Halase) recombinant protein. The method includes the following steps: (1) optimizing a halase gene; (2) performing Polymerase Chain Reaction (PCR) amplification on an optimized halase gene; (3) constructing an Agkis-pMCX expression vector, transforming plasmids to competent cells of an Escherichia coli for amplification, screening in an Amp-resistant manner for positive cloning, sequencing and extracting recombinant plasmids with correct sequencing; (4) transfecting recombinant plasmids to CHO cells; and (5) expressing the recombinant protein and identifying. According to the expression method, a recombinant halase is expressed first using the CHO cells cultured in a serum-free suspension manner; and by utilizing a bioengineering means, the actual production problems of insufficient raw material sources and unstable quality of a snake venom product are solved successfully.

Abstract: Method of making a cross metathesis product, the method comprising at least step (X) or step (Y): (X) reacting in a cross metathesis reaction a first compound comprising a terminal olefinic group with a second compound comprising a terminal olefinic group, wherein the first and the second compound may be identical or may be different from one another; or (Y) reacting in a ring-closing metathesis reaction two terminal olefinic groups which are comprised in a third compound; wherein the reacting in step (X) or step (Y) is performed in the presence of a ruthenium carbene complex comprising a [Ru?C]-moiety and an internal olefin.

Abstract: A machine learning method predicts whether a specified subject is at high risk of developing cognitive impairment based upon a data record for said specified subject, and a method of training a dual neural network for such. These methods may work by automatically classifying said subject into a first class associated with a first predicted risk of cognitive impairment or a second class associated with a second predicted risk of cognitive impairment. Subject records are obtained comprising a first set of measured data and a second set of data including results for two or more health assessment questionnaires; and a label indicating that the subject belongs to the first class or second class. These records are used to train first and second neural networks, and in the latter method these trained networks are able to predict whether a specified subject should belong to said first class or second class.

Abstract: The present disclosure describes membrane compositions and methods for preparing membrane compositions. In particular, the methods employ a layer-by-layer approach to membrane preparation. The membrane compositions provide significantly enhanced membrane performance over existing commercial membranes, particularly in terms of permeability and selectivity.

Abstract: A ReRAM device manufactured using 2-D Si2Te3 (silicon telluride) nanowires or nanoplates. The Si2Te3 nanowires exhibit a unique reversible resistance switching behavior driven by an applied electrical potential, which leads to switching of the NWs from a high-resistance state (HRS) to a low-resistance state (LRS). This switched LRS is highly stable unless the opposite potential is applied to switch the resistance back. This provides a new class of resistive switching based on semiconductor rather than dielectric materials. In several embodiments, the polarity of the initially applied potential along the Si2Te3 nanowires defines the switch “on” and “off” directions, which become permanent once set.

Abstract: The present disclosure relates to a compound and a preparation method and application thereof, the compound having a chemical structure formula of: wherein M in the formula is selected from a group consisting of CF3 or CF2H, and R1, R2, and R3 are each independently selected from a group consisting of aryl, heteroaryl, and alkyl. The compound provided by the present disclosure can be used as a trifluoroethanolation reagent or difluoroethanolation reagent as synthetic intermediates of many organic compounds, and some of the compounds have pharmaceutical activity. The preparation steps of such compounds are simplified, with mild synthesis conditions and wide applicability of substrates.

Abstract: The present invention relates to a thin-film composite (TFC) membrane composition comprising macrocycles. The invention also relates in part to a method of fabricating a TFC membrane and to a method of using the TFC membrane to separate a desired liquid or gas from a liquid or gas mixture.

Abstract: The present disclosure describes membrane compositions and methods for preparing membrane compositions. In particular, the methods employ a layer-by-layer approach to membrane preparation. The membrane compositions provide significantly enhanced membrane performance over existing commercial membranes, particularly in terms of permeability and selectivity.

Abstract: A method for fabricating a photonic integrated circuit (PIC) comprises providing a silicon-on-insulator (SOI) wafer comprising an insulator layer disposed between a base semiconductor layer and a SOI layer, wherein the SOI layer comprises a waveguide, providing at least one slot within the SOI layer, wherein the at least one slot is positioned on the same or opposite sides of the waveguide, and wherein the at least one slot is positioned at a predetermined distance away from the waveguide, and removing a portion of the insulator layer to form an etched-out portion of the insulator layer, wherein the etched-out portion is positioned directly beneath the waveguide, and wherein a width of the etched-out portion is at least the width of the waveguide.

Abstract: A free space coupling system comprising a waveguide horizontally positioned on an integrated circuit, and a silicon housing coupled to the waveguide, wherein the silicon housing comprises a reflective surface, a first port, wherein the first port is configured to receive light from an optic source positioned substantially parallel to the waveguide at a coupling point, and a second port, wherein the second port is oriented at about ninety degrees with respect to the first port, and wherein the second port is aligned with a grating port on the waveguide.

Abstract: A ReRAM device manufactured using 2-D Si2Te3 (silicon telluride) nanowires or nanoplates. The Si2Te3 nanowires exhibit a unique reversible resistance switching behavior driven by an applied electrical potential, which leads to switching of the NWs from a high-resistance state (HRS) to a low-resistance state (LRS). This switched LRS is highly stable unless the opposite potential is applied to switch the resistance back. This provides a new class of resistive switching based on semiconductor rather than dielectric materials. In several embodiments, the polarity of the initially applied potential along the Si2Te3 nanowires defines the switch “on” and “off” directions, which become permanent once set.

Abstract: Method of making a cross metathesis product, the method comprising at least step (X) or step (Y): (X) reacting in a cross metathesis reaction a first compound comprising a terminal olefinic group with a second compound comprising a terminal olefinic group, wherein the first and the second compound may be identical or may be different from one another; or (Y) reacting in a ring-closing metathesis reaction two terminal olefinic groups which are comprised in a third compound; wherein the reacting in step (X) or step (Y) is performed in the presence of a ruthenium carbene complex comprising a [Ru?C]-moiety and an internal olefin.

Abstract: (57) Abstract: The present application provides methods, compositions, delivery systems, ami kits for modifying a target nucleic acid using an Argonaute (Ago) and a single-stranded guide DNA. In some embodiments, methods of gene editing in a cell, such as a mammalian cell, arc provided.

Abstract: An apparatus comprising a polarization beam splitter optically coupled to a first light path and a second light path and configured to receive a CW light having a plurality of wavelengths, forward a first light beam of the CW light along the first light path, and forward a second light beam of the CW light along the second light path. A first multiplexer coupled to the first light path and configured to de-multiplex the first light beam into a first plurality of channels each corresponding to one of the plurality of wavelengths. A second multiplexer coupled to the second light path and configured to de-multiplex the second light beam into a second plurality of channels each corresponding to one of the plurality of wavelengths. A modulator coupled to the first multiplexer and the second multiplexer and configured to modulate the first plurality of channels and the second plurality of channels.

Abstract: A gapless optical mode converter comprising a fiber holder configured to receive and hold an optical transmission line, a first glass block coupled via an optical adhesive at a first side to the fiber holder, a lens coupled via the optical adhesive at a first side to a second side of the first glass block, and a holder configured to hold the fiber holder, the first glass block, and the lens.

Abstract: An optical modulator for generating quadrature amplitude modulation (nQAM) and phase-shift keying (nPSK) signals with tunable modulation efficiency. The modulator includes a controlling circuit for adjusting the modulation efficiency or modulation depth of the modulator by controlling the direct current (DC) bias.