Abstract: An apparatus comprising a plurality of optical transmitters coupled to a fiber, a signal generator coupled to the optical transmitters and configured to provide a single pilot tone to the optical transmitters, and a processor positioned within a feedback loop between the fiber and the optical transmitters, the processor configured to adjust a wavelength for each of the optical transmitters to lock the wavelengths. An apparatus comprising at least one processor configured to implement a method comprising receiving an optical signal comprising a pilot tone, detecting an amplitude and a phase of the pilot tone, calculating a quadrature term using the amplitude and the phase, and wavelength locking the optical signal using the quadrature term.

Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.

Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.

Abstract: An apparatus comprising a plurality of laser dice and a heat sink positioned between the laser dice and thermally coupled to the laser dice. Also included is an apparatus comprising a chip comprising a laser core, a stopper at least partially defining a groove, wherein the stopper and the groove are positioned adjacent to the chip, and a heater located between the laser core and the groove.

Abstract: Methods and compositions are provided for modulating the activity of macrophage and macrophage-like cells, particularly by modulating the peptidase activity of such cells. In certain aspects, methods are provided for enhancing or suppressing the immune function of a host by increasing or decreasing, respectively, expression of a target peptidase in host macrophage and macrophage-like cells. Such methods for enhancing or suppressing the immune function of a host by increasing or inhibiting (suppressing or silencing) expression of a target peptidase in host macrophage and macrophage-like cells find use in methods for treating and/or preventing a number of diseases and conditions, including cancer, viral and/or bacterial infection, Alzheimer's disease, tissue transplant rejection, autoimmune diseases, and chronic inflammatory diseases.

Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.

Abstract: An upgradeable optical hub and hub upgrade can be provided. The upgradeable hub can separate an incoming signal into various components and provide a segment of the incoming signal to a port for a hub upgrade. The hub can drop, for example, four channels to four external nodes. Hub upgrade can separate an incoming signal into various bands, and can drop, for example, four channels to four external nodes. The upgradeable hub, thus, can be upgraded by adding the hub upgrade, without the need for discarding the original hub when performing a hub upgrade.

Abstract: A high-speed, high-throughput matched optical filter for processing data that allows for rapid reprogramming to change the reference signal or signals. A coherent time-domain optical memory system includes a coherent time-domain optical storage material (18) and a laser (16) for providing pulses of optical radiation in coherent time-domain optical storage relation with the storage material. One or more reference signals are first stored in the material by modulating one or more of the laser pulses with the reference signals and writing these pulses on the storage material (18) in close succession with their associated write pulses as is customary in coherent time-domain optical memories. The reference signals are phase encoded before they are stored. Another laser pulse modulated with the signal to be processed is then applied to the storage material. The echo signal induced by this signal pulse takes the form of the correlation of the reference pulse with the signal pulse.