Patents by Inventor Xiao-Yi Xiao

Xiao-Yi Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20230122651
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: April 12, 2022
    Publication date: April 20, 2023
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plarnondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20230031954
    Abstract: The present invention is directed to methods of treating hematological cancers, such as acute myleiod leukemia, with tetracyclines, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 30, 2017
    Publication date: February 2, 2023
    Inventors: Xiao-Yi Xiao, Jacques P. Dumas, Diana K. Hunt, Cuixiang Sun, Peng Zhao
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20210122709
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: June 10, 2020
    Publication date: April 29, 2021
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • Tetracycline compounds
    Patent number: 10913712
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: February 9, 2021
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20200055813
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: April 1, 2019
    Publication date: February 20, 2020
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • TETRACYCLINE COMPOUNDS
    Publication number: 20200048193
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Application
    Filed: April 24, 2019
    Publication date: February 13, 2020
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • Tetracyline compounds
    Patent number: 10315992
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: June 11, 2019
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • TETRACYCLINE COMPOUNDS
    Publication number: 20190077803
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
    Type: Application
    Filed: May 2, 2018
    Publication date: March 14, 2019
    Inventors: Chi-Li Chen, Roger B. Clark, Yonghong Deng, Minsheng He, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus P. Ronn
  • C7-FLUORO SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20190002398
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: January 29, 2018
    Publication date: January 3, 2019
    Inventors: Jingye Shanghai, Xiao-Yi Xiao, Louis Plamondon, Diana K. Hunt, Roger B. Clark, Robert Zahler
  • Tetracycline compounds
    Patent number: 10072007
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: September 11, 2018
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Chi-Li Chen, Roger B. Clark, Yonghong Deng, Minsheng He, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus P. Ronn
  • TETRACYCLINE COMPOUNDS
    Publication number: 20170334841
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
    Type: Application
    Filed: March 1, 2017
    Publication date: November 23, 2017
    Inventors: Yonghong Deng, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Jingye Zhou, Joyce A. Sutcliffe, Magnus P. Ronn
  • Tetracyline Compounds
    Publication number: 20170305852
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Application
    Filed: January 6, 2017
    Publication date: October 26, 2017
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • C7-Fluoro Substituted Tetracycline Compounds
    Publication number: 20170275244
    Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
    Type: Application
    Filed: November 9, 2016
    Publication date: September 28, 2017
    Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana Katharine Hunt, Roger B. Clark, Robert Zahler
  • Polycyclic Tetracycline Compounds
    Publication number: 20170107179
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
    Type: Application
    Filed: May 25, 2016
    Publication date: April 20, 2017
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Magnus P. Ronn, Louis Plamondon, Minsheng He, Joyce A. Sutcliffe, Trudy Grossman
  • Tetracycline compounds
    Patent number: 9624166
    Abstract: The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: April 18, 2017
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Yonghong Deng, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Jingye Zhou, Joyce A. Sutcliffe, Magnus P. Ronn
  • Tetracycline compounds
    Patent number: 9573895
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: February 21, 2017
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • TETRACYCLINE COMPOUNDS
    Publication number: 20170044160
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
    Type: Application
    Filed: March 24, 2016
    Publication date: February 16, 2017
    Inventors: Chi-Li Chen, Roger B. Clark, Yonghong Deng, Minsheng He, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus P. Ronn
  • Polycyclic tetracycline compounds
    Patent number: 9371283
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: June 21, 2016
    Assignee: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger Clark, Diana Hunt, Magnus Rönn, Louis Plamondon, Minsheng He, Joyce Sutcliffe, Trudy Grossman
  • Tetracycline Compounds
    Publication number: 20160107988
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I), or a pharmaceutically acceptable salt thereof, and its therapeutic use.
    Type: Application
    Filed: August 30, 2013
    Publication date: April 21, 2016
    Applicant: Tetraphase Pharmaceuticals, Inc.
    Inventors: Xiao-Yi Xiao, Roger B. Clark, Diana Katharine Hunt, Cuixiang Sun, Magnus P. Ronn, Wu-Yan Zhang, Minsheng He
  • Tetracycline compounds
    Patent number: 9315451
    Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: April 19, 2016
    Assignee: TETRAPHASE PHARMACEUTICALS, INC.
    Inventors: Chi-Li Chen, Roger B. Clark, Yonghong Deng, Minsheng He, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Magnus Rönn