Abstract: Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.

Abstract: A vehicular L-type suspension arm is provided in which a wheel support part is provided on one end part of an arm main body, and a first vehicle body side linking portion and a second vehicle body side linking portion are provided in an intermediate part and on the other end part thereof respectively, wherein an arm main body (A) includes an upper half body (AU) having an inverted U-shaped cross-section and a lower half body (AL) that blocks the lower open end of the upper half body (AU), a first vehicle body side linking portion (AF1) is formed from front and rear support plates (SF, SR) each formed by press forming a plate material, these front and rear support plates (SF, SR) have base parts (SFa, Sra) that are integrally joined to each other, the base ends thereof being welded to an outside part of the arm main body (A), extremity parts (SFb, SRb) of the front and rear support plates (SF, SR) are arranged so as to be spaced from each other in the vehicle body fore-and-aft direction, and cylindrical bush s

Abstract: A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component.

Abstract: In various embodiments, approaches for the placement of inbound inventory in a materials handling facility are described. A product identifier is input from inbound inventory into a computer system, where the inbound inventory is to be stocked in a materials handling facility. At least one available inventory location is identified in the computer system that presents a lowest cost for storage of the inbound inventory in the materials handling facility. The inbound inventory is stocked in the at least one available inventory location contemporaneously with the determination of the at least one available inventory location in the computer system that presents the lowest cost for storage of the inbound inventory in the materials handling facility.

Abstract: A method for intra-block wear leveling within solid-state memory subjected to wear, having a plurality of memory cells includes the step of writing to at least certain ones of the plurality of memory cells, in a non-uniform manner, such as to balance the wear of the at least certain ones of the plurality of memory cells within the solid-state memory, at intra-block level. For example, if a behavior of at least some of the plurality of memory cells is not characterized, then the method may comprise characterizing a behavior of at least some of the plurality of memory cells and writing to at least certain ones of the plurality of memory cells, based on the characterized behavior, and in a non-uniform manner.

Abstract: Flash memory systems and methods for efficiently locating meta-data structures on solid-state devices, such as, flash-based memory devices, which allows for fast reconstruction of metadata structures are provided. These systems and methods place checkpoints, which identify the location of metadata structures, intelligently on the device so as to permit a more efficient method of locating such checkpoints. These techniques ensure best wear-leveling as all blocks on the device undergo the same wear-leveling strategy. These systems and methods further provide a free block maintenance strategy that provides blocks freed by garbage collection for future checkpoint writes.

Abstract: Systems and methods are provided that confront the problem of failed storage integrated circuits (ICs) in a solid state drive (SSD) by using a fault-tolerant architecture along with one error correction code (ECC) mechanism for random/burst error corrections and an L-fold interleaving mechanism. The systems and methods described herein keep the SSD operational when one or more integrated circuits fail and allow the recovery of previously stored data from failed integrated circuits and allow random/burst errors to be corrected in other operational integrated circuits. These systems and methods replace the failed integrated circuits with fully functional/operational integrated circuits treated herein as spare integrated circuits. Furthermore, these systems and methods improve I/O performance in terms of maximum achievable read/write data rate.

Abstract: A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

Abstract: A method and system for inventory placement according to expected item picking rates. In one embodiment, a method may include determining a respective expected picking rate for each of a number of inventory items, and dependent upon the expected picking rate, selecting a corresponding one of a number of zones of an inventory storage area for each of the items. The zones may be physically arranged within the inventory storage area such that a first, innermost zone is successively and at least partially surrounded by one or more other zones. The method may further include storing each of the items within the corresponding zones, such that the expected picking rates of members of a given group of items stored in a given zone are less than the expected picking rates of members of another group of items stored in a successive zone that at least partially surrounds the given zone.

Abstract: An LED lamp includes a heat sink, a plurality of LED modules mounted on a top of the heat sink and a plurality of light-guiding modules respectively fixed on the LED modules. The heat sink includes a base and a plurality of fins extending downwardly from the base. Each LED module includes a plurality of LEDs mounted thereon. Each light-guiding module includes a mounting bracket defining a plurality of through holes therein and a plurality of guiding units respectively received in the through holes of the mounting bracket. The guiding units are respectively in alignment with the LEDs of a corresponding LED module and receive the LEDs in lower ends thereof to reflect and guide light generated by the corresponding LED module in a predetermined manner.

Abstract: Drive circuitry for driving a load through a connection to a transmission line, such as for driving the write head of a hard disk drive. A hybrid termination is provided for termination at the connection to the transmission line. The termination is hybrid since there is both an in-series and an in-parallel component to the termination resistance. In addition, in embodiments where there is matched termination of the transmission line during a boost period of driving the load, the termination is hybrid since the termination is switched between a boost period of a write operation, and a steady state period of the write operation.

Abstract: Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.

Abstract: Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.

Abstract: A solid state storage device and method are provided. Multiple blocks are configured as storage memory for a solid state storage device, and each block includes multiple pages. A controller is configured to operate the solid state storage device. A free block of the multiple blocks is assigned a marker level by the controller. For a particular page of the multiple pages, each particular page of data is written to a block of the multiple blocks with a marker level corresponding to a level of dynamicity calculated by the controller for that particular page.

Abstract: A memory management system and method for managing memory blocks of a memory device of a computer. The system includes a free block data structure including free memory blocks for writing, and sorting the free memory blocks in a predetermined order based on block write-erase endurance cycle count and receiving new user-write requests to update existing data and relocation write requests to relocate existing data separately, a user-write block pool for receiving youngest blocks holding user-write data (i.e., any page being updated frequently) from the free block data structure, a relocation block pool for receiving oldest blocks holding relocation data (i.e., any page being updated infrequently) from the free block data structure, and a garbage collection pool structure for selecting at least one of user-write blocks and relocation blocks for garbage collection, wherein the selected block is moved back to the free block data structure upon being relocated and erased.

Abstract: A method and system for inventory placement according to expected item picking rates. In one embodiment, a method may include determining a respective expected picking rate for each of a number of inventory items, and dependent upon the expected picking rate, selecting a corresponding one of a number of zones of an inventory storage area for each of the items. The zones may be physically arranged within the inventory storage area such that a first, innermost zone is successively and at least partially surrounded by one or more other zones. The method may further include storing each of the items within the corresponding zones, such that the expected picking rates of members of a given group of items stored in a given zone are less than the expected picking rates of members of another group of items stored in a successive zone that at least partially surrounds the given zone.

Abstract: A circuit comprises first and second buffers, and an output buffer. The first buffer receives an input signal and provides a first buffer output signal on a first lead. The second buffer receives the input signal and provides a second buffer output signal on a second output lead. The output buffer has a first input lead coupled to the first output lead and AC coupled to the second output lead. The AC coupling communicates timing information from the second buffer to the output buffer. The first buffer applies sufficient voltage to control the first input lead of the output buffer under DC conditions.

Abstract: A driver for driving a load over a transmission line, such as driving the magnetic head of a hard disk drive. The driver includes a signal switch for switching the signal to the load during a signal period, and a boost switch for boosting the signal during a boost period, so as to decrease rise time of the signal at the load by deliberately injecting an overshoot. A switchable protection device protects the signal switch and the boost switch. The protection device includes a reflection-suppression switch which is pulsed during a time corresponding to the expected return of a reflection corresponding to the overshoot signal, so as to force the protection device into saturation mode. Since the protection device is in the saturation mode during the return reflection of the boost signal, the returned reflection sees a matched impedance and thus reduces a re-reflection back to the load.

Abstract: Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract: The present invention is directed to an implantable device comprising a biocompatible and biodegradable matrix impregnated with a bioactive complex suitable for selectively targeting the lymphatic system, wherein the bioactive complex comprises one or more particle forming materials and one or more bioactive agents. The invention is further directed to methods of using and the process of preparing, the implantable device.