Patents by Inventor Xiaobei Zeng

Xiaobei Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES
    Publication number: 20170355761
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
    Type: Application
    Filed: May 22, 2017
    Publication date: December 14, 2017
    Applicant: AbbVie Inc.
    Inventors: Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Christopher CHUMSAE
  • METHODS TO MODULATE LYSINE VARIANT DISTRIBUTION
    Publication number: 20170349655
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
    Type: Application
    Filed: June 19, 2017
    Publication date: December 7, 2017
    Applicant: AbbVie Inc.
    Inventors: Kartik Subramanian, Mayda Perez Thiele, Xiaobei Zeng, Chee Furng Wong, Christopher M. Chumsae
  • METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS USING DISSOLVED OXYGEN
    Publication number: 20170306009
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells by supplementing the production media with dissolved oxygen.
    Type: Application
    Filed: April 5, 2017
    Publication date: October 26, 2017
    Inventor: Xiaobei Zeng
  • Methods to modulate lysine variant distribution
    Patent number: 9708400
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: July 18, 2017
    Assignee: ABBVIE, INC.
    Inventors: Kartik Subramanian, Mayda Perez Thiele, Xiaobei Zeng, Chee Furng Wong, Christopher M. Chumsae
  • METHODS TO CONTROL PROTEIN HETEROGENEITY
    Publication number: 20170198034
    Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
    Type: Application
    Filed: December 2, 2016
    Publication date: July 13, 2017
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng
  • Cell culture methods to reduce acidic species
    Patent number: 9683033
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: June 20, 2017
    Assignee: ABBVIE, INC.
    Inventors: Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Christopher Chumsae
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20170158758
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: November 22, 2016
    Publication date: June 8, 2017
    Applicant: AbbVie, Inc.
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • METHODS TO CONTROL PROTEIN HETEROGENEITY
    Publication number: 20170137496
    Abstract: The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells.
    Type: Application
    Filed: January 27, 2017
    Publication date: May 18, 2017
    Applicant: AbbVie Inc.
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng
  • MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20170121403
    Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: November 16, 2016
    Publication date: May 4, 2017
    Applicant: AbbVie, Inc.
    Inventors: Kartik SUBRAMANIAN, Mayda Perez THIELE, Xiaobei ZENG, Chee Furng WONG, Zehra KAYMAKCALAN, Ying JING, Christopher M. CHUMSAE
  • Low acidic species compositions and methods for producing and using the same
    Patent number: 9522953
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: December 20, 2016
    Assignee: ABBVIE, INC.
    Inventors: Natarajan Ramasubramanyan, Lihua Yang, Matthew Omon Herigstad, Hong Yang, Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Zehra Kaymakcalan, Christopher Chumsae
  • Methods to control protein heterogeneity
    Patent number: 9512214
    Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: December 6, 2016
    Assignee: AbbVie, Inc.
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng
  • Modulated lysine variant species compositions and methods for producing and using the same
    Patent number: 9499616
    Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: November 22, 2016
    Assignee: ABBVIE INC.
    Inventors: Kartik Subramanian, Mayda Perez Thiele, Xiaobei Zeng, Chee Furng Wong, Zehra Kaymakcalan, Ying Jing, Christopher M. Chumsae
  • MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20160237150
    Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: October 27, 2015
    Publication date: August 18, 2016
    Inventors: Kartik Subramanian, Mayda Perez Thiele, Xiaobei Zeng, Chee Furng Wong, Zehra Kaymakcalan, Ying Jing, Christopher M. Chumsae
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20160194390
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: January 28, 2016
    Publication date: July 7, 2016
    Applicant: AbbVie, Inc.
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • LOW MANNOSE ADALIMUMAB COMPOSITIONS AND USES THEREOF
    Publication number: 20160159897
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells by supplementing the production media with dissolved oxygen.
    Type: Application
    Filed: January 21, 2016
    Publication date: June 9, 2016
    Inventor: Xiaobei Zeng
  • Cell culture methods to reduce acidic species
    Patent number: 9359434
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: June 7, 2016
    Assignee: AbbVie, Inc.
    Inventors: Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Christopher Chumsae
  • CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES
    Publication number: 20160145331
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
    Type: Application
    Filed: January 28, 2016
    Publication date: May 26, 2016
    Applicant: AbbVie Inc.
    Inventors: Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Christopher CHUMSAE
  • METHODS TO CONTROL PROTEIN HETEROGENEITY
    Publication number: 20160138064
    Abstract: The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells.
    Type: Application
    Filed: December 3, 2015
    Publication date: May 19, 2016
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng
  • Low acidic species compositions and methods for producing and using the same
    Patent number: 9315574
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: April 19, 2016
    Assignee: AbbVie, Inc.
    Inventors: Natarajan Ramasubramanyan, Lihua Yang, Matthew Omon Herigstad, Hong Yang, Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Zehra Kaymakcalan, Christopher Chumsae
  • Methods to control protein heterogeneity
    Patent number: 9290568
    Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: March 22, 2016
    Assignee: AbbVie, Inc.
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng