Patents by Inventor Xiaobei Zeng

Xiaobei Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Low acidic species compositions and methods for producing and using the same
    Patent number: 9266949
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: February 23, 2016
    Assignee: AbbVie, Inc.
    Inventors: Natarajan Ramasubramanyan, Lihua Yang, Matthew Omon Herigstad, Hong Yang, Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Zehra Kaymakcalan, Christopher Chumsae
  • METHODS TO MODULATE LYSINE VARIANT DISTRIBUTION
    Publication number: 20160046708
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
    Type: Application
    Filed: October 27, 2015
    Publication date: February 18, 2016
    Inventors: Kartik Subramanian, Mayda Perez Thiele, Xiaobei Zeng, Chee Furng Wong, Christopher M. Chumsae
  • METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS USING DISSOLVED OXYGEN
    Publication number: 20160039924
    Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells by supplementing the production media with dissolved oxygen.
    Type: Application
    Filed: July 30, 2015
    Publication date: February 11, 2016
    Inventor: Xiaobei Zeng
  • CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES
    Publication number: 20160039925
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
    Type: Application
    Filed: September 2, 2015
    Publication date: February 11, 2016
    Inventors: Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Christopher Chumsae
  • Methods to control protein heterogeneity
    Patent number: 9234033
    Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: January 12, 2016
    Assignee: AbbVie, Inc.
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng
  • Methods to control protein heterogeneity
    Patent number: 9206390
    Abstract: The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 8, 2015
    Assignee: AbbVie, Inc.
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng
  • Low acidic species compositions and methods for producing and using the same
    Patent number: 9200069
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: December 1, 2015
    Assignee: AbbVie, Inc.
    Inventors: Natarajan Ramasubramanyan, Lihua Yang, Matthew Omon Herigstad, Hong Yang, Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Zehra Kaymakcalan, Christopher Chumsae
  • Low acidic species compositions and methods for producing and using the same
    Patent number: 9200070
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: December 1, 2015
    Assignee: AbbVie, Inc.
    Inventors: Natarajan Ramasubramanyan, Lihua Yang, Matthew Omon Herigstad, Hong Yang, Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Zehra Kaymakcalan, Christopher Chumsae
  • Methods to modulate lysine variant distribution
    Patent number: 9181572
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: November 10, 2015
    Assignee: AbbVie, Inc.
    Inventors: Kartik Subramanian, Mayda Perez, Xiaobei Zeng, Chee Furng Wong, Christopher Chumsae
  • Modulated lysine variant species compositions and methods for producing and using the same
    Patent number: 9181337
    Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: November 10, 2015
    Assignee: AbbVie, Inc.
    Inventors: Kartik Subramanian, Mayda Perez Thiele, Xiaobei Zeng, Chee Furng Wong, Zehra Kaymakcalan, Ying Jing, Christopher Chumsae
  • Cell culture methods to reduce acidic species
    Patent number: 9150645
    Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 6, 2015
    Assignee: AbbVie, Inc.
    Inventors: Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Christopher Chumsae
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150259410
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: May 15, 2015
    Publication date: September 17, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua Yang, Matthew Omon Herigstad, Hong Yang, Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Zehra Kaymakcalan, Christopher Chumsae
  • Low acidic species compositions and methods for producing and using the same
    Patent number: 9085618
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimxental, are also provided.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: July 21, 2015
    Assignee: AbbVie, Inc.
    Inventors: Natarajan Ramasubramanyan, Lihua Yang, Matthew Omon Herigstad, Hong Yang, Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Zehra Kaymakcalan, Christopher Chumsae
  • METHODS TO CONTROL PROTEIN HETEROGENEITY
    Publication number: 20150183865
    Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
    Type: Application
    Filed: February 26, 2015
    Publication date: July 2, 2015
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng
  • METHODS TO CONTROL PROTEIN HETEROGENEITY
    Publication number: 20150183866
    Abstract: The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins expressed in host cells.
    Type: Application
    Filed: February 26, 2015
    Publication date: July 2, 2015
    Inventors: Lisa M. Rives, Cornelia Bengea, Xiaobei Zeng
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150166650
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: December 29, 2014
    Publication date: June 18, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150140006
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: February 4, 2015
    Publication date: May 21, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua Yang, Matthew Omon Herigstad, Hong Yang, Kartik Subramanian, Xiaobei Zeng, Diane D. Dong, Wen Chung Lim, Kathreen A. Gifford, Zehra Kaymakcalan, Christopher Chumsae
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150132801
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: December 18, 2014
    Publication date: May 14, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150110799
    Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: November 12, 2013
    Publication date: April 23, 2015
    Inventors: Natarajan RAMASUBRAMANYAN, Lihua YANG, Matthew Omon HERIGSTAD, Hong YANG, Kartik SUBRAMANIAN, Xiaobei ZENG, Diane D. DONG, Wen Chung LIM, Kathreen A. GIFFORD, Zehra KAYMAKCALAN, Christopher CHUMSAE
  • MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
    Publication number: 20150110775
    Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNF? is detrimental, are also provided.
    Type: Application
    Filed: November 12, 2013
    Publication date: April 23, 2015
    Inventors: Kartik SUBRAMANIAN, Mayda PEREZ THIELE, Xiaobei ZENG, Chee Furng WONG, Zehra KAYMAKCALAN, Ying JING, Christopher CHUMSAE