Abstract: A method of transporting biomolecular cargo intracellularly into cells includes the operations of providing magnetic nanostructures (e.g., nanospears, nanostars, nanorods, and other nanometer-sized structures) carrying the biomolecular cargo thereon and applying an external magnetic field to move the magnetic nanostructures into physical contact with at least some of the cells (or the cells into the magnetic nanostructures). The magnetic nanostructures move into physical contact with a single cell, a subset of cells, or all cells. The external magnetic field may be applied by a moving permanent magnet although an electromagnetic may also be used. The biomolecular cargo may include a molecule, a plurality of molecules, or higher order biological constructs.

Abstract: A hollow-core antiresonant fiber (HC-ARF) with nested supporting rings (NSRs) has a fiber structure that includes from the inside out a fiber core, a first silica antiresonant ring (SARR), a first air antiresonant ring (AARR), a second SARR, a second AARR and an external silica wall. The fiber structure further includes a first NSR within the first AARR and a second NSR within the second AARR. The HC-ARF with NSRs has advantages and benefits of low confined loss (CL), large bandwidth, simple structure and very good bending characteristics. Therefore, the application fields of HC-ARF are greatly expanded.

Abstract: A method for characterizing or quantifying one or more proteins in visible and/or sub-visible particles formed in a sample by detecting the at least one visible or sub-visible particle in the sample, isolating and capturing the at least one visible or sub-visible particle to identify a presence of a protein, and using a mass spectrometer to characterize the protein.

Abstract: The nondestructive determination of core size of a hollow-core photonic bandgap fiber (HC-PBF) using Fabry-Perot (FP) interference is performed with an apparatus including a tunable laser source (TLS), a 1×2 single-mode (SM) coupler, an SM collimator, a six-axis translation stage, an optical detector, and an oscilloscope. The light from the TLS passes through the 1×2 SM coupler and the SM collimator to perpendicularly enter two parallel air-SiO2 interfaces of the core of the fiber and is reflected, while the TLS is tuned from one wavelength to another. Then the reflected spectrum is guided to the optical detector, where its interference intensity is converted into voltage intensity to be displayed at the oscillator and fitted with a least-squares method to obtain the distance between the two air-SiO2 interfaces. The core size of the fiber can be obtained by rotating the fiber and repeating the procedure at multiple angular positions.

Abstract: A robust and general fabrication/manufacturing method is described herein for the fabrication of periodic three-dimensional (3D) hierarchical nanostructures in a highly scalable and tunable manner. This nanofabrication technique exploits the selected and repeated etching of spherical particles that serve as resist material and that can be shaped in parallel for each processing step. The method enables the fabrication of periodic, vertically aligned nanotubes at the wafer scale with nanometer-scale control in three dimensions including outer/inner diameters, heights/hole-depths, and pitches. The method was utilized to construct 3D periodic hierarchical hybrid silicon and hybrid nanostructures such as multi-level solid/hollow nanotowers where the height and diameter of each level of each structure can be configured precisely as well as 3D concentric plasmonic supported metal nanodisk/nanorings with tunable optical properties on a variety of substrates.

Abstract: A vehicle type identification method and device based on mobile phone data for solving the problem of providing a convenient and low-cost vehicle type identification method. The method includes: obtaining trajectory data recorded by a mobile phone of a user within a period of time; judging mobile phone users who are on the same vehicle according to the data, and obtaining a vehicle trajectory and the number of passengers corresponding to the vehicle trajectory; obtaining a vehicle origin and destination according to the vehicle trajectory, and obtaining an origin-destination type of the vehicle trajectory in combination with geographic data; obtaining vehicle driving data according to the vehicle trajectory; and obtaining service area data of vehicle staying according to the vehicle trajectory. The cost of obtaining data by using mobile phone big data and by using mobile phone signaling data collected and provided by an operator is low.

Abstract: Systems and methods for determining regions of proteins that contribute to the viscosity of formulations of those proteins are provided. Methods for modifying the viscosity of concentrated protein formulations are also provided.

Abstract: The nondestructive determination of core size of a hollow-core photonic bandgap fiber (HC-PBF) using Fabry-Perot (FP) interference is performed with an apparatus including a tunable laser source (TLS), a 1×2 single-mode (SM) coupler, an SM collimator, a six-axis translation stage, an optical detector, and an oscilloscope. The light from the TLS passes through the 1×2 SM coupler and the SM collimator to perpendicularly enter two parallel air-SiO2 interfaces of the core of the fiber and is reflected, while the TLS is tuned from one wavelength to another. Then the reflected spectrum is guided to the optical detector, where its interference intensity is converted into voltage intensity to be displayed at the oscillator and fitted with a least-squares method to obtain the distance between the two air-SiO2 interfaces. The core size of the fiber can be obtained by rotating the fiber and repeating the procedure at multiple angular positions.

Abstract: Methods of predicting an in vivo serum concentration of an antibody with a post-translational modification of interest after administration of the antibody are provided, as are methods for predicting a subject's exposure to post-translational variants of the antibody. The methods include predicting a percentage of the antibody with the post-translational modification of interest using an in vivo rate constant determined for the post-translational modification, and multiplying the predicted percentage of the antibody with the post-translational modification of interest by the in vivo concentration of the antibody to determine the concentration of the antibody with the post-translational modification of interest.

Abstract: The present invention includes nanotubes or rods, methods and arrays using plasmonic-magnetic bifunctional nanotubes or rods comprising: one or more silica nanotubes or rods; one or more nanomagnets embedded in a portion of the silica nanotubes or rods; and plasmonic metal nanoparticles uniformly coating in or on at least a portion of the surface of the nanomagnets and the silica nanotubes surface-coated.

Abstract: A vehicle type identification method and device based on mobile phone data for solving the problem of providing a convenient and low-cost vehicle type identification method. The method includes: obtaining trajectory data recorded by a mobile phone of a user within a period of time; judging mobile phone users who are on the same vehicle according to the data, and obtaining a vehicle trajectory and the number of passengers corresponding to the vehicle trajectory; obtaining a vehicle origin and destination according to the vehicle trajectory, and obtaining an origin-destination type of the vehicle trajectory in combination with geographic data; obtaining vehicle driving data according to the vehicle trajectory; and obtaining service area data of vehicle staying according to the vehicle trajectory. The cost of obtaining data by using mobile phone big data and by using mobile phone signaling data collected and provided by an operator is low.

Abstract: A bionic visual navigation control system for autonomous aerial refueling docking includes: a tanker/receiver bottom layer control module, a multi-wind disturbances hose-drogue stable control module, an enable and select module, a close-range bionic vision relative navigation module, and a receiver relative position precise control module. A bionic visual navigation control method for autonomous aerial refueling docking is also provided. The present invention aims at improving the reliability, anti-interference and accuracy of the close-range relative navigation in the autonomous air refueling docking stage, and designs a matching relative position accurate control method with control switch, thereby improving the accuracy of close-range navigation and control, thereby promoting the successful realization of probe-and-drogue autonomous aerial refueling and improving the autonomy of UAVs.

Abstract: A UAV autonomous swarm formation rotation control method based on a simulated migratory bird evolutionary snowdrift game includes steps of: Step 1: initializing; Step 2: determining flight mode based on a migratory bird evolutionary snowdrift game; Step 3: determining the leader and its position relative to corresponding wing UAV; Step 4: running UAV model; and Step 5: determining whether to end simulation. The present invention is to provide a distributed UAV autonomous swarm formation rotation control method, so as to improve robustness and adaptability of the UAV in autonomous swarm formation rotation, thus effectively improving long-range mission execution capability of the UAV.

Abstract: The present invention includes an apparatus and a method of making a three dimensional graphite structure with a controlled porosity comprising: plating a metal layer on at least one of a nickel, an iron or a cobalt foam substrate; annealing the metal and the nickel, iron or cobalt foam into a porous metal-nickel, iron or cobalt catalyst, wherein the catalyst has a smooth and a porous surface; etching the smooth surface of the annealed porous metal-nickel, iron or cobalt catalyst; growing a carbonaceous layer on the porous surface of the annealed porous metal-nickel, iron or cobalt catalyst; and completely etching the porous metal-nickel, iron or cobalt catalyst to obtain the graphite layer.

Abstract: The present invention includes an apparatus and a method of making a three dimensional graphite structure with a controlled porosity comprising: plating a metal layer on at least one of a nickel, an iron or a cobalt foam substrate; annealing the metal and the nickel, iron or cobalt foam into a porous metal-nickel, iron or cobalt catalyst, wherein the catalyst has a smooth and a porous surface; etching the smooth surface of the annealed porous metal-nickel, iron or cobalt catalyst; growing a carbonaceous layer on the porous surface of the annealed porous metal-nickel, iron or cobalt catalyst; and completely etching the porous metal-nickel, iron or cobalt catalyst to obtain the graphite layer.

Abstract: The present invention includes nanotubes or rods, methods and arrays using plasmonic-magnetic bifunctional nanotubes or rods comprising: one or more silica nanotubes or rods; one or more nanomagnets embedded in a portion of the silica nanotubes or rods; and plasmonic metal nanoparticles uniformly coating in or on at least a portion of the surface of the nanomagnets and the silica nanotubes surface-coated.

Abstract: The present invention includes nanotubes or rods, methods and arrays using plasmonic-magnetic bifunctional nanotubes or rods comprising: one or more silica nanotubes or rods; one or more nanomagnets embedded in a portion of the silica nanotubes or rods; and plasmonic metal nanoparticles uniformly coating in or on at least a portion of the surface of the nanomagnets and the silica nanotubes surface-coated.

Abstract: The present invention includes an apparatus and a method of making a three dimensional graphite structure with a controlled porosity comprising: plating a metal layer on at least one of a nickel, an iron or a cobalt foam substrate; annealing the metal and the nickel, iron or cobalt foam into a porous metal-nickel, iron or cobalt catalyst, wherein the catalyst has a smooth and a porous surface; etching the smooth surface of the annealed porous metal-nickel, iron or cobalt catalyst; growing a carbonaceous layer on the porous surface of the annealed porous metal-nickel, iron or cobalt catalyst; and completely etching the porous metal-nickel, iron or cobalt catalyst to obtain the graphite layer.

Abstract: The present invention includes nanotubes or rods, methods and arrays using plasmonic-magnetic bifunctional nanotubes or rods comprising: one or more silica nanotubes or rods; one or more nanomagnets embedded in a portion of the silica nanotubes or rods; and plasmonic metal nanoparticles uniformly coating in or on at least a portion of the surface of the nanomagnets and the silica nanotubes surface-coated.

Abstract: A spraying device for multiphase material, comprising: a cylinder, a pair of liquid-conveying pipes, a pair of material-conveying pipes, a nozzle, a pair of switches, at least one pair of storage chambers, a pair of valves, a mixing chamber, and a conveying pump; wherein the conveying pump is connected to the storage chambers via the liquid-conveying pipes, the conveying pump, the switches and the valves control material transmission of the material-conveying pipes, the conveying pump is connected to the mixing chamber via the material-conveying pipes, and the mixing chamber is disposed in front of the nozzle.