Patents by Inventor Xiaocheng Chen

Xiaocheng Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CD47 ANTIBODIES AND USES THEREOF
    Publication number: 20240174750
    Abstract: Disclosed herein are antibodies that bind specifically to CD47 and have optimized functional and safety properties.
    Type: Application
    Filed: March 22, 2022
    Publication date: May 30, 2024
    Inventors: Xinhua WANG, Xiaocheng CHEN, Oi Kwan WONG, Leonard POST
  • METHODS OF ENGINEERING TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES
    Publication number: 20240141058
    Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
    Type: Application
    Filed: January 9, 2024
    Publication date: May 2, 2024
    Applicant: Denali Therapeutics Inc.
    Inventors: Xiaocheng Chen, Mark S. Dennis, Mihalis Kariolis, Adam P. Silverman, Ankita Srivastava, Ryan J. Watts, Robert C. Wells, Joy Yu Zuchero
  • Anti-tryptase antibodies, compositions thereof, and uses thereof
    Patent number: 11939396
    Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: March 26, 2024
    Assignee: Genentech, Inc.
    Inventors: Xiaocheng Chen, Mark Dennis, Janet Jackman, James T. Koerber, Mason Lu, Henry R. Maun, Kathila Rajapaksa, Saroja Ramanujan, Tracy Staton, Lawren Wu, Tangsheng Yi
  • Methods of engineering transferrin receptor binding polypeptides
    Patent number: 11912778
    Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: February 27, 2024
    Assignee: Denali Therapeutics Inc.
    Inventors: Xiaocheng Chen, Mark S. Dennis, Mihalis Kariolis, Adam P. Silverman, Ankita Srivastava, Ryan J. Watts, Robert C. Wells, Joy Yu Zuchero
  • EXPRESSION AND SECRETION SYSTEM
    Publication number: 20240043831
    Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
    Type: Application
    Filed: March 10, 2023
    Publication date: February 8, 2024
    Inventors: Devin TESAR, Xiaocheng CHEN, Mark DENNIS, Isidro HOTZEL
  • ENGINEERED TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES
    Publication number: 20240024432
    Abstract: Provided herein are polypeptides that bind to a transferrin receptor, Fc dimers and fusion proteins comprising such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
    Type: Application
    Filed: September 8, 2023
    Publication date: January 25, 2024
    Applicant: Denali Therapeutics Inc.
    Inventors: Xiaocheng Chen, Mark S. Dennis, Mihalis Kariolis, Adam P. Silverman, Ankita Srivastava, Ryan J. Watts, Robert C. Wells, Joy Yu Zuchero
  • ENGINEERED TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES
    Publication number: 20240018253
    Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
    Type: Application
    Filed: September 11, 2023
    Publication date: January 18, 2024
    Applicant: Denali Therapeutics Inc.
    Inventors: Xiaocheng Chen, Mark S. Dennis, Mihalis Kariolis, Adam P. Silverman, Ankita Srivastava, Ryan J. Watts, Robert C. Wells, Joy Yu Zuchero
  • Engineered transferrin receptor binding polypeptides
    Patent number: 11795232
    Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: October 24, 2023
    Assignee: Denali Therapeutics Inc.
    Inventors: Xiaocheng Chen, Mark S. Dennis, Mihalis Kariolis, Adam P. Silverman, Ankita Srivastava, Ryan J. Watts, Robert C. Wells, Joy Yu Zuchero
  • HUMANIZED CD38 AND ICAM1 ANTIBODIES AND USES THEREOF
    Publication number: 20230312740
    Abstract: Disclosed herein are humanized anti-CD38 antibodies, humanized anti-ICAMl antibodies, and bispecific antibodies comprising humanized anti-CD38 and anti-ICAMl binding domains and methods of using humanized anti-CD38 antibodies, humanized anti-rCAMl antibodies, and bispecific antibodies comprising humanized anti-CD38 and anti-ICAMl binding domains for killing tumor cells and inhibiting tumor growth.
    Type: Application
    Filed: May 14, 2021
    Publication date: October 5, 2023
    Inventor: Xiaocheng CHEN
  • Anti-CD3 antibodies and methods of use
    Patent number: 11732054
    Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: August 22, 2023
    Assignee: Genentech, Inc.
    Inventors: Xiaocheng Chen, Mark S. Dennis, Allen J. Ebens, Jr., Teemu T. Junttila, Robert F. Kelley, Mary A. Mathieu
  • Engineered polypeptides
    Patent number: 11732023
    Abstract: Provided herein are polypeptides that bind to a blood-brain barrier (BBB) receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a BBB receptor-expressing cell, e.g., for transport across the BBB. Also provided herein are transferrin receptor (TfR) constructs that comprise a monomeric TfR apical domain or one or more portions of the TfR apical domain which have been circularly permuted relative to the full-length TfR sequence.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: August 22, 2023
    Assignee: Denali Therapeutics Inc.
    Inventors: Xiaocheng Chen, Mihalis Kariolis, Robert C. Wells
  • METHODS OF ENGINEERING TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES
    Publication number: 20230235072
    Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
    Type: Application
    Filed: August 15, 2022
    Publication date: July 27, 2023
    Applicant: Denali Therapeutics Inc.
    Inventors: Xiaocheng Chen, Mark S. Dennis, Mihalis Kariolis, Adam P. Silverman, Ankita Srivastava, Ryan J. Watts, Robert C. Wells, Joy Yu Zuchero
  • MULTISPECIFIC ANTIBODIES TARGETING CD38 AND BCMA AND USES THEREOF
    Publication number: 20230183381
    Abstract: Disclosed herein are multispecific antibodies comprising a CD38 binding domain and an BCMA binding domain. Further provided herein are methods of treating cancer comprising administering to a subject having cancer a pharmaceutical composition comprising a multispecific antibody comprising a CD38 binding domain and an BCMA binding domain.
    Type: Application
    Filed: May 12, 2021
    Publication date: June 15, 2023
    Inventors: Xiaocheng CHEN, Leonard POST
  • BISPECIFIC ANTIBODIES FOR TREATING CD47-ASSOCIATED DISEASES
    Publication number: 20230159663
    Abstract: Disclosed herein are bispecific antibodies comprising a first targeting moiety that specifically binds to CD47 and a second targeting moiety that specifically binds to EpCAM or EGFR and, pharmaceutical compositions and methods comprising the bispecific antibodies.
    Type: Application
    Filed: April 23, 2021
    Publication date: May 25, 2023
    Inventors: Xinhua WANG, Xiaocheng CHEN, Lei SHI, Leonard POST, Oi Kwan WONG
  • Anti-HER2 Antibodies and Immunoconjugates
    Publication number: 20230041134
    Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: April 14, 2022
    Publication date: February 9, 2023
    Applicant: Genentech, Inc.
    Inventors: Xiaocheng Chen, Mark Dennis, Jagath Reddy Junutula, Gail Lewis Phillips, Thomas Harden Pillow, Mark X. Sliwkowski
  • ANTI-CD3 ANTIBODIES AND METHODS OF USE
    Publication number: 20230002506
    Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
    Type: Application
    Filed: September 6, 2022
    Publication date: January 5, 2023
    Inventors: Xiaocheng CHEN, Mark S. Dennis, Allen J. Ebens, JR., Robert F. Kelley, Mary A. Mathieu, Liping L. Sun
  • Anti-CD3 antibodies and methods of use
    Patent number: 11530275
    Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: December 20, 2022
    Assignee: Genentech, Inc.
    Inventors: Xiaocheng Chen, Mark S. Dennis, Allen J. Ebens, Jr., Teemu T. Junttila, Robert F. Kelley, Mary A. Mathieu
  • Anti-CLL-1 antibodies and methods of use
    Patent number: 11466087
    Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: October 11, 2022
    Assignee: Genentech, Inc.
    Inventors: Robert F. Kelley, Steven R. Leong, Wei-Ching Liang, Mary Mathieu, Andrew G. Polson, Bing Zheng, Xiaocheng Chen, Cecilia Pui Chi Chiu, Mark S. Dennis, Allen Ebens, Yan Wu
  • Pillow
    Patent number: D982355
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: April 4, 2023
    Inventor: Xiaocheng Chen
  • Flashlight
    Patent number: D1035943
    Type: Grant
    Filed: April 15, 2024
    Date of Patent: July 16, 2024
    Inventor: Xiaocheng Chen