Patents by Inventor Xiaodong Wu

Xiaodong Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12037648
    Abstract: The present disclosure belongs to the field of livestock molecular biotechnology, and provides kits and methods for pedigree division and paternity testing of domestic pigs. The kits and methods specifically select 14 SSR loci of domestic pigs, especially Anqing six-end-white pigs, and synthesize primers for corresponding loci. Through capillary electrophoresis detection of the ear tissue DNA of 98 Anqing six-end-white pigs, the count of effective alleles, heterozygosity, polymorphism information content, and genetic distance, and exclusion probability at each locus are calculated, the pedigree division of domestic pigs, especially Anqing six-end-white pigs, and paternity testing are conducted. The cumulative exclusion probability of 14 microsatellite loci is 99%.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: July 16, 2024
    Assignee: ANHUI AGRICULTURAL UNIVERSITY
    Inventors: Yueyun Ding, Xiaoling Ding, Zongjun Yin, Xudong Wu, Xiaodong Zhang, Xianrui Zheng, Zijing Ling, Qiong Chen, Yinhui Hou, Chengcheng Kong
  • Patent number: 11949392
    Abstract: An apparatus comprising a first circuit and a circuit. The first circuit may be configured to receive an input signal, split the input signal into component signals and present the component signals to a plurality of amplifiers. The second circuit may be configured to receive amplified component signals from the amplifiers and combine the amplified component signals into an output signal. The circuits may each comprise an outer conductor, an inner conductor, a cavity and a plurality of blades. Each of the blades may be arranged evenly spaced along a surface within the cavity and extend along a length of the surface with a shape. The shape of the blades may have a probe and the shape may gradually meet the surface and may be configured to provide a low-loss transition for propagation of a microwave signal. The output signal may be an amplified version of said input signal.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: April 2, 2024
    Assignee: Mission Microwave Technologies, LLC
    Inventors: Michael P. DeLisio, Jr., Donald Xiaodong Wu, Nathaniel Schultz, Blythe C. Deckman
  • Patent number: 11949146
    Abstract: An apparatus including an inner conductor and an outer conductor. The inner conductor may comprise a cylindrical portion, a tapered end and a plurality of blades. The blades may be arranged around the cylindrical portion and extend along a length of the cylindrical portion with a predetermined shape. The shape may have a probe at a first end and a second end of the shape may meet the cylindrical portion. The tapered end may have an input/output (I/O) transition. The outer conductor may comprise a cavity, a first connector and a plurality of second connectors. The inner conductor may be within the cavity. The first connector may be connected to the I/O transition. Each of the second connectors may be connected to the probe of one of the blades. The shape of each of the blades may be configured to provide a low-loss transition for a microwave signal.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: April 2, 2024
    Assignee: Mission Microwave Technologies, LLC
    Inventors: Michael P. DeLisio, Jr., Donald Xiaodong Wu, Nathaniel Schultz, Blythe C. Deckman
  • Patent number: 11939238
    Abstract: The present disclosure provides an apparatus and a method for hydrate-based wastewater treatment and cold storage. The apparatus for hydrate-based wastewater treatment and cold storage includes a water chilling unit, a hydrate-based cold storage tank, an airflow disturbance device, a water layer positioning system, a spraying system, a suction filtration system, a heat exchange system, and a system monitoring device. The water chilling unit provides a secondary refrigerant at a low temperature. The secondary refrigerant flows through an evaporator coil in the hydrate-based cold storage tank for heat exchange. The airflow disturbance device induces hydrate nucleation. The water layer positioning system positions a contact surface between a water layer and a hydrate former after hydrate decomposition to facilitate drawing and separation of the treated upper water layer. The spraying system and the suction filtration system enhance the solid-liquid separation efficiency to improve the removal rate of pollutants.
    Type: Grant
    Filed: May 15, 2023
    Date of Patent: March 26, 2024
    Assignee: DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Lunxiang Zhang, Yongchen Song, Xiaodong Wu, Jiazhu Bao, Chuanxiao Cheng, Zheng Ling, Jie Wang, Fan Wang, Yu Liu, Lei Yang, Mingjun Yang, Yanghui Li, Peng Wu
  • Publication number: 20230365431
    Abstract: The present disclosure provides an apparatus and a method for hydrate-based wastewater treatment and cold storage. The apparatus for hydrate-based wastewater treatment and cold storage includes a water chilling unit, a hydrate-based cold storage tank, an airflow disturbance device, a water layer positioning system, a spraying system, a suction filtration system, a heat exchange system, and a system monitoring device. The water chilling unit provides a secondary refrigerant at a low temperature. The secondary refrigerant flows through an evaporator coil in the hydrate-based cold storage tank for heat exchange. The airflow disturbance device induces hydrate nucleation. The water layer positioning system positions a contact surface between a water layer and a hydrate former after hydrate decomposition to facilitate drawing and separation of the treated upper water layer. The spraying system and the suction filtration system enhance the solid-liquid separation efficiency to improve the removal rate of pollutants.
    Type: Application
    Filed: May 15, 2023
    Publication date: November 16, 2023
    Applicant: DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Lunxiang ZHANG, Xiaodong WU, Jiazhu BAO, Xiaohang XIE, Yongchen SONG, Jiafei ZHAO, Ruize CUI, Zisong FAN, Yunhui WANG, Qinjian YU, Jie WANG
  • Publication number: 20230312722
    Abstract: Provided are a B7H4-targeting antibody or a variant thereof, and a bispecific antibody containing the B7H4-targeting antibody, wherein the B7H4-targeting antibody comprises a light chain variable region and a heavy chain variable region. The variant has an amino acid mutation in the light chain variable region or heavy chain variable region of the antibody and can maintain the function of the antibody. The B7H4-targeting antibody has the activity of binding to human B7H4 and cynomolgus macaque B7H4, and does not cross-react with other B7 family members. The B7H4-targeting antibody exhibits good anti-tumor activity, T-cell activation activity and internalization activity in in-vivo and in-vitro experiments, and is more suitable for use as an ADC drug. Further provided is a bispecific antibody targeting B7H4 and CD3, which has a longer half-life, retains good stability and hydrophilicity, and reduces toxicity while ensuring efficacy.
    Type: Application
    Filed: June 29, 2021
    Publication date: October 5, 2023
    Applicant: NONA BIOSCIENCES (SUZHOU) CO., LTD.
    Inventors: Xiaodong WU, Yongqiang WANG, Fei CHEN, Jinqiu HE, Gezi JIA, Chuchu ZHAO, Qingfang CHEN, Yiping RONG
  • Publication number: 20230303698
    Abstract: The present invention provides a binding protein and use thereof, wherein the binding protein comprises a first protein functional region binding to a targeting moiety of an antigen on a target cell, and a second protein functional region binding to an effector moiety of an antigen on an immune effector cell; and the binding protein is selected from the following structure: the first protein functional region is of a Fab structure, the second protein functional region is of a VH structure or a Fab structure, and the first protein functional region and the second protein functional region are arranged sequentially from the N-terminus to the C-terminus of the binding protein. The binding protein can bring the immune effector cell and the specific target cell together, efficiently and selectively activate the immune effector cell in a microenvironment of the specific target cell, further enhance immune responses, and reduce toxic and side effects caused by non-specific activation of peripheral immune cells.
    Type: Application
    Filed: June 29, 2021
    Publication date: September 28, 2023
    Inventors: Yun HE, Lei SHI, Xiaodong WU, Chen ZHONG, Bing HUANG, Yiping RONG
  • Publication number: 20230264043
    Abstract: A method for needle position optimization for prostate brachytherapy for use with a radiation delivery device configured to use a plurality of needles inserted into a prostate of a patient includes obtaining imagery of the prostate of the patient, generating a needle pool for prostate brachytherapy treatment of the patient based on the imagery of the prostate of the patient, and determining at a computing device an optimum prostate brachytherapy treatment plan for the patient by iteratively removing needles from the needle pool by forming and computationally solving a convex optimization problem wherein the convex optimization problem uses a quadratic dosimetric penalty function, dwell time regularization by total variation, and block sparsity regularization term.
    Type: Application
    Filed: February 17, 2023
    Publication date: August 24, 2023
    Applicant: University of Iowa Research Foundation
    Inventors: Xiaodong Wu, Weiyu Xu, Jirong Yi
  • Publication number: 20230235090
    Abstract: Provided are a bispecific antibody and use thereof. The bispecific antibody comprises a B7-H4-targeting antigen-binding domain and a 4-1BB-targeting antigen-binding domain. The bispecific antibody has one or two or three sites for binding to 4-1BB, along with a novel fully human B7-H4 antibody. The bispecific antibody specifically binds to tumor cells by targeting B7-H4, reducing toxicity induced by 4-1BB activation. In addition, the bispecific antibody of the present invention comprises a human Fc fragment, and thus retains the binding of Fc to FcRn and has a longer half-life.
    Type: Application
    Filed: June 29, 2021
    Publication date: July 27, 2023
    Applicant: HARBOUR BIOMED US, INC.
    Inventors: Lei SHI, Chen ZHONG, Xiaodong WU, Yun HE, Fei CHEN, Xiaocheng LV, Jinli XIE, Yiping RONG, Bing HUANG, Fangfang DU, Jianxun ZHAO
  • Patent number: 11541251
    Abstract: Methods and systems are described for a rotating shield brachytherapy device. As disclosed herein, the rotating shield brachytherapy (RSBT) apparatus may comprise a radiation source, a drive assembly, a catheter, and an applicator. The applicator can have an outer surface and opposed proximal and distal end portions and a longitudinal axis extending along a length of the catheter. The distal end portion of the catheter can comprise one or more radiation shields and is configured to receive the radiation source. The drive assembly can be configured to engage the proximal end portion of the catheter to selectively rotate the catheter about the longitudinal axis.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: January 3, 2023
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Ryan T. Flynn, Yusung Kim, Xiaodong Wu, Karolyn M. Hopfensperger, Quentin E. Adams
  • Publication number: 20220404309
    Abstract: Potentiometric sensors based on potentiometric mechanosensation and/or thermosensation mechanisms operate by regulating the potential difference between electrodes at two different electrode/electrolyte interfaces. A potentiometric sensor may include at least a first electrode, a second electrode, and a microstructured ionic hydrogel composite electrolyte in contact with the first electrode and the second electrode. Methods of making a potentiometric sensor device may include forming a first electrode on a substrate, forming a second electrode on the substrate, and applying a microstructured ionic hydrogel composite electrolyte structure in contact with both the first and second electrodes.
    Type: Application
    Filed: May 16, 2022
    Publication date: December 22, 2022
    Inventors: Ana Claudia Arias, Xiaodong Wu
  • Patent number: 11353613
    Abstract: A seismic exploration method includes performing a true amplitude PSDM based on an initial velocity model of a subsurface formation to obtain a reflectivity model, and then a Born modeling using the reflectivity model to generate synthetic data. An image-based reflection full waveform inversion is applied to a cost function of differences between seismic data acquired over the subsurface formation and the synthetic data to update the initial velocity model. The updated velocity model enables exploring the presence of and/or assisting in the extraction of natural resources from the subsurface formation.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: June 7, 2022
    Assignee: CGG SERVICES SAS
    Inventors: Min Wang, Yi Xie, Xiaodong Wu, Dechun Lin
  • Publication number: 20220167928
    Abstract: Methods and systems for image segmentation and analysis are described. A predictive model may be trained to identify and/or extract a rich set of image features with extensive prognostic value. For example, the predictive model may be trained to identify and/or extract features that that may be visualized to identify areas of interest (e.g., high-risk regions, etc.) within or adjacent to an object of interest, such a tumor. The predictive model may be trained to identify and/or extract features that that may predict a health related outcome, such as cancer patient survival/death, and modify therapeutic outcomes, such as diagnosis and treatment.
    Type: Application
    Filed: February 27, 2020
    Publication date: June 2, 2022
    Inventors: STEPHEN BAEK, YUSEN HE, XIAODONG WU, YUSUNG KIM, BRYAN G. ALLEN, JOHN BUATTI, BRIAN J. SMITH
  • Publication number: 20220146340
    Abstract: Flexible pressure sensors and wearable devices incorporating one or more flexible pressure sensors, and methods of making the same. A flexible pressure sensor includes a first layer including a plurality of pressure-sensitive microstructures, and a second layer including one or more electrode pairs, each of the one or more electrode pairs including a first electrode positioned adjacent a second electrode on the second layer. The first and second electrodes may be positioned on the second layer in a side-by-side configuration.
    Type: Application
    Filed: October 18, 2021
    Publication date: May 12, 2022
    Inventors: Ana Claudia Arias, Xiaodong Wu, Yasser T. Khan, Jonathan KangYu Ting, Natasha Ariane Diniz Yamamoto
  • Patent number: 11308993
    Abstract: Provided are a short video synthesis method and apparatus, a device and a storage medium. The method includes: obtaining a video frame set corresponding to a to-be-processed video, where each video frame in the video frame set carries a timestamp; respectively inputting all video frames in the video frame set into an interest frame identification model to obtain a plurality of to-be-synthesized video frames, where the interest frame identification model is used for identifying a video frame meeting an interest degree condition in the input video frames; and splicing, according to the timestamp carried by the each to-be-synthesized video frame, the plurality of to-be-synthesized video frames to form a short video corresponding to the to-be-processed video.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: April 19, 2022
    Assignee: GUANGZHOU HUYA INFORMATION TECHNOLOGY CO., LTD.
    Inventors: Zihao Xu, Xiaodong Wu
  • Patent number: 11305321
    Abstract: A hydraulic forming machine, including a body provided with a feed inlet penetrating a first mounting surface, a cutting mechanism, a forming die, an ejector arranged on the forming die, and a driving mechanism. The forming die includes a movable die and a fixed die matched with each other. The cutting mechanism and the fixed die are provided on the first mounting surface of the body and respectively at two sides of the discharge end of the feed inlet. The movable die is arranged on the driving mechanism and driven by the driving mechanism to move close to or away from the fixed die in a direction perpendicular to the first mounting surface. The cutting mechanism is configured to cut a blank at an output end of the conveying inlet. The blank cut by the cutting mechanism is extruded between the fixed die and the movable die.
    Type: Grant
    Filed: June 8, 2019
    Date of Patent: April 19, 2022
    Assignee: XI'AN METALWK HYDRAUMATIC MACHINERY CO., LTD.
    Inventors: Shixiong Chen, Yanjuan Wang, Zhenzhong Wang, Shujuan Tang, Jian Yang, Chun Yin, Xiaodong Wu, Dan Wu, Jingyun Zhao, Haiyan Liu, Xiaohui Ji
  • Patent number: 11288808
    Abstract: Disclosed are systems and methods for image segmentation using convolutional networks. Image data comprising an image hypervolume can be received. The image hypervolume can be provided to a trained convolutional neural network (CNN). The CNN can output a segmentation of the image hypervolume.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: March 29, 2022
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael Abramoff, Xiaodong Wu
  • Patent number: 11284128
    Abstract: Disclosed are an object positioning method, a video display method, an apparatus, a device, and a storage medium. The method includes: continuously intercepting a preset number of video frames in a video stream to be detected; detecting a first frame image in the intercepted video frames by a You Only Look Once (YOLO) object detection method to obtain a first positioning result corresponding to the first frame image; detecting each of other frame images in the intercepted video frames by a Kernel Correlation Filter (KCF) object tracking method according to a positioning result corresponding to a frame image prior to the each of the other frame images to obtain respective second positioning results corresponding to the other frame images; and keeping on continuously intercepting the preset number of video frames in the video stream to be detected and obtaining corresponding positioning results until the video stream to be detected is finished.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: March 22, 2022
    Assignee: GUANGZHOU HUYA INFORMATION TECHNOLOGY CO., LTD.
    Inventors: Gaosheng Ren, Xiaodong Wu, Lu Liu
  • Publication number: 20220081394
    Abstract: A method for preparing sodium taurine as a taurine intermediate is provided in the present disclosure. The method comprises the following steps: providing sodium hydroxyethyl sulfonate and an ammonia source; and placing the sodium hydroxyethyl sulfonate and the ammonia source in an aminolysis reactor for an aminolysis reaction to obtain a mixture containing sodium taurine as a taurine intermediate, wherein the molar ratio of ammonia in the ammonia source to the sodium hydroxyethyl sulfonate is greater than or equal to 25:1. A method for preparing taurine is further provided.
    Type: Application
    Filed: May 27, 2020
    Publication date: March 17, 2022
    Inventors: Zhirong CHEN, Xianghua YAO, Junhua PENG, Yingxia PAN, Xiaoxiang HE, Songhua XU, Xiaodong WU, Xiang FANG
  • Patent number: D1024441
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: April 23, 2024
    Inventor: Xiaodong Wu