Abstract: The present invention advantageously provides a method and system for providing accurately localized, non-invasive radiation treatment for ocular melanoma or other intraocular indications through the completion of specified research tasks. The present invention further provides for dynamic localization of tumors associated with such indications. The system of the present invention includes the CYBERKNIFE system, a robust eye pupil tracking system, and an integrated software package to achieve intra-beam fractional tumor tracking during radiation delivery. The system may further include a mechanical phantom incorporated with a radiation dosimetry calibration kit for validation.

Abstract: A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

Abstract: An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and (iii) comparing said genetic polymorphism patterns to a reference composite genotype pattern; wherein the similarity of said genetic polymorphism patterns to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease.

Abstract: The invention disclosed herein aims to standardize and simplify the process of preparing Ex-Vivo autologous whole tumor cell vaccines. The present invention is a robust, stand-alone device and system for preparing autologous tumor cell vaccines in a completely self-contained sterile environment, and in a shortened time. This new device and system will process the extracted tumor with its associated stromal and endothelial cells into injectable tumor cell vaccines, administered automatically or semi-automatically. This invention incorporates a number of new biotechnologies to enhance therapeutic effects over other existing methods. This invention will allow a medical facility to prepare and administer autologous cancer cell vaccine therapy independently without having, or using, a GMP facility, while adhering to and maintaining GMP guidelines.

Abstract: This invention is a video line encapsulation protocol which allows multiple low definition video streams to be combined into a single super frame of high definition video data. Each super frame is formed of individual lines from plural lower definition video input signals. The high definition video frames include meta data in each line identifying the video input source, line and frame. This meta data enables the super frames to be separated into their component input signals within a video processing digital signal processor.

Abstract: An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and (iii) comparing said genetic polymorphism patterns to a reference composite genotype pattern; wherein the similarity of said genetic polymorphism patterns to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease.

Abstract: A porous lithium manganese phosphate-carbon composite material, and a preparation and application thereof. Multiple nano-pores are distributed in the composite material, and the composite material includes a lithium manganese phosphate material and carbon. The method for preparing the porous lithium manganese phosphate-carbon composite material includes the steps of: mixing a porous pyrophosphate material with a doped metal source, a lithium source, phosphate and a carbon source and then drying them to obtain a reaction precursor, and calcining the reaction precursor at a constant temperature under a protective atmosphere to obtain the composite material. The lithium manganese phosphate material contains compounds in a general formula of LiMnxM1?xPO4, and the porous pyrophosphate material contains compounds in a general formula of (MnxM1?x)2P2O7 and 0 wt % to 50 wt % of carbon, where M comprises a transition metal, and 0.6?x?1.

Abstract: Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. In an aspect, the invention is a shielded needle or catheter system with a rotational controller for delivering radioisotope-based interstitial rotating shield brachytherapy (I-RSBT), In an aspect, I-RSBT needles can deliver dose distributions that can be non-radially symmetric about each needle, enabling reduced doses to sensitive normal tissues. Further provided are methods and systems for selecting an emission angle for use in S-RSBT and for sequencing the rotating shields. Further provided are methods and system for the multiple application of M-RSBT in a single setting.

Abstract: The present invention provides for a biocompatible drug delivery device for the targeted treatment of cancer that is implantable within the tumorous mass of a patient. In one embodiment, the device comprises two polarizable elements mechanically coupled by a connecting element. The device also comprises one or more cancer treatment agents. When the polarizable elements are depolarized, such as by the application of ionizing radiation, the two polarizable elements are repelled from each other and release the cancer treatment agent. In another embodiment, one or more treatment agents are expelled from a miniaturized syringe when internal pressure of the device is increased by the production of gas bubbles in response to the application of ionizing radiation.

Abstract: The present invention advantageously provides a method and system for providing accurately localized, non-invasive radiation treatment for ocular melanoma or other intraocular indications through the completion of specified research tasks. The present invention further provides for dynamic localization of tumors associated with such indications. The system of the present invention includes the CYBERKNIFE system, a robust eye pupil tracking system, and an integrated software package to achieve intra-beam fractional tumor tracking during radiation delivery. The system may further include a mechanical phantom incorporated with a radiation dosimetry calibration kit for validation.

Abstract: The present invention typically provides one-component polyurethane grout compositions and more specially to grout composition useful for seepage control and quick stoppage of water leakage under high water pressure environment, wherein the composition comprises a isocyanate prepolymer and auxiliary components selected from a plasticizer, a silane coupling agent, a catalyst, a cell stabilizer, an anionic surfactant, a filler, a blowing agent or a mixture thereof. The invention also provides the isocyanate prepolymer composition, obtained by reacting a polyfunctional isocyanate, with a polyfunctional polyol comprising at least one polyether polyol containing relatively low amount of ethylene oxide units, and optionally other polyfunctional polyols such as polyester polyols, biorenewable polyols or a mixture thereof, and at least a monofunctional hydroxyl containing compound, wherein the NCO content of said prepolymer is 3%˜18%.

Abstract: A method for fiducial-less real-time motion tracking of abdominal tumors based on the correlation between the patient's breathing pattern and the diaphragm/lung border during treatment delivery. This invention utilizes an edge detection technique to delineate the diaphragm/lung border on radiographic images in order to calculate or determine tumor locations in the abdomen. The position of the diaphragm/lung border is synchronized with the breathing pattern obtained from continuous optical monitoring of a patient's respiratory cycle. The real-time optical breathing pattern obtained from monitoring is used to determine or calculate the position of the diaphragm/lung border during treatment delivery. The position of the diaphragm/lung border is then used to determine the tumor location in real-time.

Abstract: A method and apparatus for precisely reproducing the position of a vaginal cylinder in relation to a patient to ensure that a planned radiation dose can be delivered with high precision to the intended treatment target volumes. Treatment delivery is carried out by using an image-guided system to locate the position of the vaginal cylinder and comparing it to the coordinate of the vaginal cylinder obtained in the treatment plan. The displacement in the position of the vaginal cylinder from the treatment plan is corrected by calculating the transformation matrix and entering the resulting value into a position adjusting assembly which is attached to vaginal cylinder. The position adjusting assembly adjusts the vaginal cylinder to exactly reproduce its location relative to the patient's anatomy, eliminating geometric and dosimetric error.

Abstract: A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

Abstract: A gel electrolyte, a preparing method thereof, a gel electrolyte battery and a preparing method thereof are provided. The gel electrolyte comprises a non-aqueous solvent and a gel constituent, wherein the non-aqueous solvent comprises lithium salt, and the gel constituent comprises polyethylene glycol compounds with unsaturated double bonds, ester monomers with unsaturated double bonds, silane coupling agents and thermal initiators.

Abstract: A microwave motion sensor including a patch antenna having a plurality of microwave radiating elements for transmitting and receiving a microwave signal where each microwave radiating element is of the antenna in an array configuration. A reflector is disposed above the antenna for downward shaping the radiating signal, where the microwave radiating elements together with the reflector provide a radiation pattern where a main beam is transmitted in a direction orthogonal to a surface of said antenna and a sided lobe transmitted downward in amplitude below the microwave motion sensor.

Abstract: An improved method and kit of determining whether a patient is predisposed to having severe periodontal disease and/or having high risk of progression of periodontal disease, comprising the steps of (i) taking a biological sample from said patient; (ii) genotyping said biological sample for genetic polymorphism pattern comprising IL 1B (rs16944), IL 1B (rs1143623) and IL 1B (rs4848306); and (iii) comparing said genetic polymorphism patterns to a reference composite genotype pattern; wherein the similarity of said genetic polymorphism patterns to said reference pattern indicate said patient's predisposition to having severe periodontal disease and/or having high risk of progression of periodontal disease.

Abstract: A system and methods for the efficient segmentation of globally optimal surfaces representing object boundaries in volumetric datasets is provided. An optical surface detection system and methods are provided that are capable of simultaneously detecting multiple interacting surfaces in which the optimality is controlled by the cost functions designed for individual surfaces and by several geometric constraints defining the surface smoothness and interrelations. The present invention includes surface segmentation using a layered graph-theoretic approach that optimally segments multiple interacting surfaces of a single object using a pre-segmentation step, after which the segmentation of all desired surfaces of the object are performed simultaneously in a single optimization process.

Abstract: A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

Abstract: A system and methods for the efficient segmentation of globally optimal surfaces representing object boundaries in volumetric datasets is provided. An optical surface detection system and methods are provided that are capable of simultaneously detecting multiple interacting surfaces in which the optimality is controlled by the cost functions designed for individual surfaces and by several geometric constraints defining the surface smoothness and interrelations. The graph search applications use objective functions that incorporate non-uniform cost terms such as “on-surface” costs as well as “in-region” costs.