Abstract: The present disclosure provides a preparation method of a titanium implant with a surface coating in a crater-like porous shape. A titanium substrate is subjected to polishing, cleaning, and first drying in sequence to obtain a pretreated titanium substrate. This step eliminates an influence of roughness and surface impurities of the titanium substrate on roughness and a structure of a coating formed on a surface of the titanium substrate after micro-arc oxidation, so as to obtain a titanium implant with a specific structure and a desirable biological performance. The micro-arc oxidation is conducted using the pretreated titanium substrate as an anode and iron as a cathode in an electrolyte containing sodium phosphate. In this step, a micro-arc oxidation coating is formed on the surface of the titanium substrate to obtain the titanium implant with a surface coating in a crater-like porous shape.

Abstract: A control method of a mechanical arm, a mechanical arm assembly, and a readable storage medium. The mechanical arm includes a parallel platform which includes a movable platform, a static platform and a telescopic element connecting the movable platform and the static platform, and the method includes: acquiring a current pose of the movable platform in a mechanical coordinate system, wherein the mechanical coordinate system is a global coordinate system of the mechanical arm where the movable platform is located; acquiring, according to the current pose of the movable platform, a target pose of a static platform in the mechanical coordinate system; performing pose transformation on the static platform according to the current pose of the movable platform and the target pose of the static platform.

Abstract: Disclosed is a copper-niobium alloy for a medical biopsy puncture needle. A needle core and/or needle tube of the puncture needle are/is made of the copper-niobium alloy. The copper-chromium alloy includes the following components by mass: 5?Nb?15 and the balance of Cu. A copper alloy with designed components is obtained by combining a diamagnetic material Cu with paramagnetic Nb, and compared with existing medical stainless steel and titanium alloy, the copper alloy has greatly reduced magnetic susceptibility, and specifically, the artifact area and volume are also significantly reduced. In addition, the blank of use of the copper alloy in medical biopsy paracentesis is filled.

Abstract: The disclosure discloses a sofa backrest connection structure, including a first member and a second member, the first member includes a first base plate, two guide rails symmetrically arranged on the first base plate, and a limiting part arranged on the first base plate, and the limiting part is provided with a clamping protrusion; the second member includes a second base plate and a first horizontal plate connected to the second base plate, the second base plate includes an insertion part, and the insertion part is provided with a clamping hole matched with the clamping protrusion; after the insertion part is slidably inserted into and fitted with the two guide rails, the clamping protrusion is clamped in the clamping hole; and the first horizontal plate is used for being connected with a sofa seat frame, and the first base plate is used for being connected with a sofa backrest.

Abstract: The invention discloses a sofa seat frame, a sofa base assembly, a sofa and a sofa production and assembly process, the sofa seat frame comprises two cross beams arranged at intervals and two longitudinal beams connecting the two cross beams, wherein a plurality of supporting elastic pieces are arranged between the two cross beams; and each longitudinal beam comprises a first supporting plate for supporting a seat cushion and a first side plate arranged at one side of the lower part of the first supporting plate and used for being detachably connected with sofa fabric on the seat cushion. In the sofa seat frame provided by the invention, when the seat cushion is placed on the supporting elastic pieces, the first supporting plates can give a certain supporting force to the seat cushion, so as to improve the sitting comfort of users.

Abstract: A linkage device for implementing no backrest clearance, a supporting frame, a seat unit, and a seat, including a bottom base, a linkage mechanism, a support side plate, and a backrest mechanism; the support side plate is provided with a side plate linkage point and a backrest point; the support side plate is rotatably connected to the linkage mechanism at the side plate linkage point; the support side plate is rotatably connected to the backrest mechanism at the backrest point; the backrest mechanism includes a backrest mounting member and a backrest linkage member; and when the backrest mechanism is retracted to an ultimate position, an included angle ? between a connecting line between two ends of the backrest mounting member and a connecting line between the backrest point and the side plate linkage point is an acute angle.

Abstract: Provided is a chimeric antigen receptor, comprising an antigen binding region, a transmembrane domain and an intracellular signaling region. The antigen binding region comprises an antibody specifically targeting CD7, and the intracellular signaling region consists of a co-stimulatory domain, a primary signal transduction domain, and a ?C chain or intracellular region thereof. Also provided are an engineered immune cell comprising the chimeric antigen receptor and a pharmaceutical composition thereof, and use of the engineered immune cell/pharmaceutical composition for treating cancers.

Abstract: The present disclosure provides a fiber membrane and a preparation method and use thereof, and belongs to the field of biological materials. The fiber membrane includes a fiber with a core-shell structure, where a core of the fiber includes simvastatin and a first spinnable polymer, and a shell of the fiber includes hydroxyapatite and a second spinnable polymer. In the fiber, a release of the simvastatin mainly depends on a rate of water invasion. After water invades the fiber, the simvastatin in the fiber leaves the fiber with the diffusion of water. In the present disclosure, a barrier function of the shell prevents moisture from entering the core. Therefore, the simvastatin in the core cannot leave the fiber with the diffusion of water molecules in an early stage, and a release rate of drugs is slowed down in the early stage, thereby controlling sustained release of the drugs.

Abstract: The present disclosure provides a hydrophilic fiber membrane with a sustained-release drug, and belongs to the field of biological materials. The present disclosure provides a hydrophilic fiber membrane with a sustained-release drug, including a fiber with a core-shell structure, where a core of the fiber includes curcumin and a first spinnable polymer, and a shell of the fiber includes polyethylene glycol and a second spinnable polymer; and in the shell, the polyethylene glycol and the second spinnable polymer have a mass ratio of not greater than 1:12. In the present disclosure, the fiber membrane has a core-shell structure, the curcumin is provided in the core, and the shell prevents a rapid release of the curcumin in an early stage, thereby delaying a release rate of the curcumin to prevent the drug from forming a burst release in the early stage and causing toxic reactions.

Abstract: A projection curtain is provided in the present invention. The projection curtain at least comprises a reflective layer and one of a colored layer, a diffusion layer, and a Fresnel lens layer. The Fresnel lens layer is a spherical Fresnel lens layer or an aspherical Fresnel lens layer. The Fresnel lens layer comprises a plurality of annular protrusions protruding from a plane, the plurality of annular protrusions are arranged in circular bands. A cross-sectional shape of each annular protrusion along a cross section perpendicular to the plane is a triangular shape or a multi-step shape or a free surface shape. The width of one side of each cross-sectional shape parallel to the plane gradually changes, and gradual change of the cross-sectional shape and the width thereof determines light gathering characteristics of the spherical Fresnel lens layer or the aspherical Fresnel lens layer. A surface of each annular protrusion has scattered microstructures.

Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: A hybrid master-slave mapping method includes the following steps: acquiring a current position and a target position of an end point of a robotic arm; decomposing a displacement from the current position to the target position into a vertical direction and a horizontal plane to obtain a vertical displacement position and a horizontal displacement position; determining a first control amount of a multi-degree-of-freedom parallel platform according to the vertical displacement position, and determining a second control amount of a passive arm according to the horizontal displacement position; controlling the multi-degree-of-freedom parallel platform according to the first control amount, and controlling the passive arm according to the second control amount.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The invention provides an offline handwriting individual recognition system and method based on two-dimensional dynamic features.

Abstract: The present disclosure relates to compounds that are capable of inhibiting the ENPP1 gene and treating a variety of cardiac conditions. The disclosure further relates to methods of treating or preventing cardiac conditions, such as myocardial infarction and heart failure.