Abstract: Disclosed in the present invention are a polypeptide fragment, a derivative of the polypeptide fragment, and applications of the derivative of the polypeptide in the preparation of drugs for preventing and treating fibrosis diseases.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: Provided herein are KRN2 gene controlling kernel row number in plant, molecular markers closely linked to KRN2 and their application in molecular breeding.

Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

Abstract: A method for suppressing coherent and polarization-induced fading by simultaneous monitoring of loss and vibration is provided. By using merely common single-mode sensing fibers, the polarization diversity-based measurement method solves the conflict between ?-OTDR and COTDR in terms of polarization state. In addition, the method not only achieves a better coherent fading noise suppression effect but also enhances the capability of recognizing small loss events in the monitoring of loss parameters. Meanwhile, the method can suppress the influence of coherent fading on the phase demodulation of ?-OTDR and reconstruct a vibration signal with high fidelity in the monitoring of perturbation parameters, which can effectively reduce the error rate of external perturbation warning.

Abstract: Embodiments of the present disclosure belong to the field of valve sealing, and in particular, relate to a test device for simulating sealing performance of a one-way valve. A box is provided with a gas inlet pipe and a gas outlet pipe, the gas inlet pipe is communicated with a gas source, a detection device is communicated with the gas outlet pipe, the detection device is used to detect detection gas input into the box by the gas source, a sleeve is connected to the gas inlet pipe, one end of the sleeve is communicated with the gas source, the other end of the sleeve has a gas outlet, one end of a fitting piece is used to block the gas outlet, and the other end of the fitting piece is connected to a driving member, which is used to drive the fitting piece to move and rotate.

Abstract: Provided is an anti-Henipavirus monoclonal antibody having broad spectrum neutralization activity, wherein the antibody comprises a macaque variable region and a human constant region. The antibody of the present invention has good binding activity to both Nipah virus glycoprotein G and Hendra virus glycoprotein G, can effectively neutralize Nipahpseudovirus and Hendra pseudovirus, and can be used for preparing drugs for treating Henipavirus diseases.

Abstract: The technology relates in part to binding molecules that specifically bind to a polypeptide that is the Isoform 2 of mesotheiin, or that specifically bind to an antigenic determinant (epitope) of the isoform 2 of mesotheiin, or that specifically bind to polypeptides containing an antigenic determinant (epitope) of the isoform 2 of mesotheiin, chimeric PD1 receptors that bind to PD ligands such as PDLs, to polynucleotides including vectors that encode such binding molecules, to ceils presenting such binding molecules and to methods of making such cells, to humanized forms of the binding molecules, and to methods of using such binding molecules, such as for treating cancers (e.g., ovarian cancers and mesotheliomas), including cancers in which the Isoform 2 of mesotheiin is specifically expressed and/or upregulated relative to normal tissues.

Abstract: The technology relates in part to binding molecules that specifically bind to a polypeptide that is the Isoform 2 of mesothelin, or that specifically bind to an antigenic determinant (epitope) of the isoform 2 of mesothelin, or that specifically bind to polypeptides containing an antigenic determinant (epitope) of the isoform 2 of mesothelin, chimeric PD1 receptors that bind to PD ligands such as PDLs, to polynucleotides including vectors that encode such binding molecules, to ceils presenting such binding molecules and to methods of making such cells, to humanized forms of the binding molecules, and to methods of using such binding molecules, such as for treating cancers (e.g., ovarian cancers and mesotheliomas), including cancers in which the Isoform 2 of mesothelin is specifically expressed and/or upregulated relative to normal tissues.

Abstract: The present invention provides a system for on-line flame photometric detection of the content of sulfur-containing compounds in natural gas.

Abstract: The present invention provides an offline handwriting individual recognition system and method. The method comprises: scanning the suspicious handwriting to obtain a first white light image and a first three-dimensional image, and scanning the sample handwriting to obtain a second white light image and a second three-dimensional image; pre-processing the first white light image and the second white light image to obtain a first pre-processed image and a second pre-processed image; extracting a first skeleton image and a second skeleton image from the first pre-processed image and the second pre-processed image; obtaining a first writing trajectory and a second writing trajectory according to the first skeleton image and the second skeleton image; extracting a first dynamic feature, a first three-dimensional feature, and a second dynamic feature, a second three-dimensional feature; processing to obtain a correlation coefficient, and obtaining an individual recognition result.

Abstract: Disclosed in the present invention are a polypeptide fragment, a derivative of the polypeptide fragment, and applications of the derivative of the polypeptide in the preparation of drugs for preventing and treating fibrosis diseases.

Abstract: The present disclosure provides a preparation method of a titanium implant with a surface coating in a crater-like porous shape. A titanium substrate is subjected to polishing, cleaning, and first drying in sequence to obtain a pretreated titanium substrate. This step eliminates an influence of roughness and surface impurities of the titanium substrate on roughness and a structure of a coating formed on a surface of the titanium substrate after micro-arc oxidation, so as to obtain a titanium implant with a specific structure and a desirable biological performance. The micro-arc oxidation is conducted using the pretreated titanium substrate as an anode and iron as a cathode in an electrolyte containing sodium phosphate. In this step, a micro-arc oxidation coating is formed on the surface of the titanium substrate to obtain the titanium implant with a surface coating in a crater-like porous shape.

Abstract: A control method of a mechanical arm, a mechanical arm assembly, and a readable storage medium. The mechanical arm includes a parallel platform which includes a movable platform, a static platform and a telescopic element connecting the movable platform and the static platform, and the method includes: acquiring a current pose of the movable platform in a mechanical coordinate system, wherein the mechanical coordinate system is a global coordinate system of the mechanical arm where the movable platform is located; acquiring, according to the current pose of the movable platform, a target pose of a static platform in the mechanical coordinate system; performing pose transformation on the static platform according to the current pose of the movable platform and the target pose of the static platform.

Abstract: Disclosed is a copper-niobium alloy for a medical biopsy puncture needle. A needle core and/or needle tube of the puncture needle are/is made of the copper-niobium alloy. The copper-chromium alloy includes the following components by mass: 5?Nb?15 and the balance of Cu. A copper alloy with designed components is obtained by combining a diamagnetic material Cu with paramagnetic Nb, and compared with existing medical stainless steel and titanium alloy, the copper alloy has greatly reduced magnetic susceptibility, and specifically, the artifact area and volume are also significantly reduced. In addition, the blank of use of the copper alloy in medical biopsy paracentesis is filled.

Abstract: The present disclosure provides a fiber membrane and a preparation method and use thereof, and belongs to the field of biological materials. The fiber membrane includes a fiber with a core-shell structure, where a core of the fiber includes simvastatin and a first spinnable polymer, and a shell of the fiber includes hydroxyapatite and a second spinnable polymer. In the fiber, a release of the simvastatin mainly depends on a rate of water invasion. After water invades the fiber, the simvastatin in the fiber leaves the fiber with the diffusion of water. In the present disclosure, a barrier function of the shell prevents moisture from entering the core. Therefore, the simvastatin in the core cannot leave the fiber with the diffusion of water molecules in an early stage, and a release rate of drugs is slowed down in the early stage, thereby controlling sustained release of the drugs.