Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The invention provides an offline handwriting individual recognition system and method based on two-dimensional dynamic features.

Abstract: The present disclosure relates to compounds that are capable of inhibiting the ENPP1 gene and treating a variety of cardiac conditions. The disclosure further relates to methods of treating or preventing cardiac conditions, such as myocardial infarction and heart failure.

Abstract: Disclosed are a master-slave mapping method for parallel platform, and a robotic arm system and a storage medium. The method comprises: acquiring a first transformation relationship between a user coordinate system and a calculation coordinate system; mapping displacement amounts of an end of a master manipulator in a master user coordinate system to an end of the movable platform according to a set proportional coefficient, to obtain a first target position of the end of the movable platform; determining a second target position of the end of the movable platform according to the first transformation relationship and the first target position; obtaining a movement amount of each of the telescopic rods of the parallel platform according to the second target position, and controlling a motion of the parallel platform according to the movement amount of each of the telescopic rods. The control of the robotic arm is simplified.

Abstract: The invention discloses an underwater umbilical cable which is capable of temperature and vibration measuring and three-dimensional shape reconstruction, wherein underwater umbilical cable is used to connect underwater equipment and aquatic equipment; the underwater umbilical cable comprises an outer sheath, armored steel wires, an inner sheath, a power cable, a communication optical cable, a steel pipe, three strain measuring optical fibers, three temperature measuring optical fibers, a distributed optical fiber strain interrogator, a distributed optical fiber temperature interrogator and a processor. The invention can collect the operation status data of the umbilical cable for a long time. The collected data is highly objective, can truly reflect the real-time operation status of the umbilical cables, and plays an important role in guaranteeing the long-term submarine oil and gas exploitation.

Abstract: A foldable clamp-on desk lamp with a multi-angle adjustment function includes: a lamp base part, a clamping base, several supporting rods, and detachable rotating shaft assemblies through which the several supporting rods are movably connected and the lamp base part is connected to the uppermost supporting rod. The lowermost supporting rod is detachably connected to the clamping base. The detachable rotating shaft assemblies can achieve folding and telescopic functions, complete disassembly, repeated disassembly, assembly and change, and long service life. By the design combining a Fresnel lens and convolutional lines, light is continuously scattered and recombined when passing through the convolutional lines, so that the outgoing light is more uniformly, soft, and not dazzling. A plurality of inserting holes are formed at the upper side and top end of the clamping base, thereby facilitating multi-directional assembling of the supporting rods and achieving wide application of the clamping position.

Abstract: A method for suppressing coherent and polarization-induced fading by simultaneous monitoring of loss and vibration is provided. By using merely common single-mode sensing fibers, the polarization diversity-based measurement method solves the conflict between ?-OTDR and COTDR in terms of polarization state. In addition, the method not only achieves a better coherent fading noise suppression effect but also enhances the capability of recognizing small loss events in the monitoring of loss parameters. Meanwhile, the method can suppress the influence of coherent fading on the phase demodulation of ?-OTDR and reconstruct a vibration signal with high fidelity in the monitoring of perturbation parameters, which can effectively reduce the error rate of external perturbation warning.

Abstract: A control method for a surgical robotic arm, a computer device and a surgical robotic arm are provided. The control method includes calculating a telecentric fixed point on an executing rod according to a target point and controlling a preoperative positioning assembly to advance a first movable platform of a telecentric manipulating assembly along a first coordinate axis of a movable coordinate system; calculating a first origin coordinate of an origin of the first movable platform in a stationary coordinate system according to the coordinate of the telecentric fixed point and the trajectory coordinate of an end point; calculating the length of a first telescopic element of the telecentric manipulating assembly according to the coordinates of a hinge point of the telecentric manipulating assembly in the stationary coordinate system; and controlling the first movable platform to move to a designated pose.

Abstract: The present invention provides an offline handwriting individual recognition system and method. The method comprises: scanning the suspicious handwriting to obtain a first white light image and a first three-dimensional image, and scanning the sample handwriting to obtain a second white light image and a second three-dimensional image; pre-processing the first white light image and the second white light image to obtain a first pre-processed image and a second pre-processed image; extracting a first skeleton image and a second skeleton image from the first pre-processed image and the second pre-processed image; obtaining a first writing trajectory and a second writing trajectory according to the first skeleton image and the second skeleton image; extracting a first dynamic feature, a first three-dimensional feature, and a second dynamic feature, a second three-dimensional feature; processing to obtain a correlation coefficient, and obtaining an individual recognition result.

Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.

Abstract: The invention provides an offline handwriting individual recognition system and method based on two-dimensional dynamic features.

Abstract: The present disclosure discloses use of a copper-chromium alloy in a medical biopsy puncture needle. The copper-chromium alloy used as a material for a needle core and/or needle tube of the puncture needle. The copper-chromium alloy includes the following components by mass: 10?Cr?20, 0.04?Zr?0.1, and the balance of Cu. According to the present disclosure, a copper alloy with designed components is obtained by combining a diamagnetic material Cu with paramagnetic Cr and Zr, and compared with existing medical stainless steel and titanium alloy, the copper alloy has greatly reduced magnetic susceptibility, and specifically, the artifact area and volume are also significantly reduced. In addition, the blank of use of the copper alloy in medical biopsy paracentesis is filled.

Abstract: The invention discloses an underwater umbilical cable which is capable of temperature and vibration measuring and three-dimensional shape reconstruction, wherein underwater umbilical cable is used to connect underwater equipment and aquatic equipment; the underwater umbilical cable comprises an outer sheath, armored steel wires, an inner sheath, a power cable, a communication optical cable, a steel pipe, three strain measuring optical fibers, three temperature measuring optical fibers, a distributed optical fiber strain interrogator, a distributed optical fiber temperature interrogator and a processor. The invention can collect the operation status data of the umbilical cable for a long time. The collected data is highly objective, can truly reflect the real-time operation status of the umbilical cables, and plays an important role in guaranteeing the long-term submarine oil and gas exploitation.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.