Abstract: The present disclosure relates to the field of medicinal chemistry, and specifically relates to a compound with interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitory activity, and pharmaceutical compositions and applications thereof. The present disclosure provides a compound of Formula (I) as an effective IRAK4 inhibitor, which can be used for the prevention and/or treatment of IRAK4-related diseases and/or conditions.

Abstract: A field wheat stem tillering number extraction method, including: acquiring field wheat point clouds by means of a LiDAR, and extracting any row of wheat point clouds in a research area; projecting a Y axis to a plane, and retaining an X and Z axis; applying adaptive layering to obtain number of clusters of the wheat row; applying hierarchical clustering analysis to obtain tillering number of each wheat cluster; and further obtaining stem tillering number of the whole wheat row, so as to extract a field wheat stem tillering number. The feasibility of an algorithm is verified by comparing the wheat stem tillering number extracted by means of the method with an actually measured field stem tillering number, and the method realizes rapid, accurate and nondestructive extraction of a large-field crop stem tillering number and provides theoretical basis and technical support for extraction of the field wheat stem tillering number.

Abstract: The present disclosure provides a method and system for high-precision localization of a surface of an object, the method including: making marks with a pre-set distribution density on the surface of the object; photographing the marked object and numbering the marks in the image; acquiring relative position information about each mark on the surface of the object and establishing a corresponding relationship between mark numbers and mark position information; acquiring a real-time to-be-measured image and detecting marks in the real-time to-be-measured image; and calculating to obtain a position of the surface of the object corresponding to the current real-time to-be-measured image. The system includes: a mark making module, a numbering module, a mark position relationship module, a to-be-measured image module and a physical quantity calculation module.

Abstract: The present disclosure provides phosphonate-containing heterocycle compounds with TYK2 kinase inhibitory activity, pharmaceutical compositions comprising the same, and applications thereof. The present disclosure provides compounds of Formula (I), as inhibitors of TYK2 kinase. These compounds can be used for preventing and/or treating TYK2 kinase-related diseases and/or conditions.

Abstract: The present disclosure provides heterocycle compounds with RIP2 kinase inhibitory activity, pharmaceutical compositions comprising the same, methods using the same and applications thereof. The present disclosure provides compounds of Formula (I), as inhibitors of RIP2 kinase. These compounds can be used for preventing and/or treating RIP2 kinase-related diseases and/or conditions.

Abstract: The present disclosure provides heteroaryl compounds of Formula I, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the programmed necrosis pathway.

Abstract: A system with deep reinforcement learning based control determines optimal actions for major components in a commercial building to minimize operation costs while maximizing comprehensive comfort levels of occupants. An unsupervised deep Q-network method is introduced to handle the energy management problem by evaluating the influence of operation costs on comfort levels considering the environment factors at each time slot. An optimum control decision can be derived that targets both immediate and long-term goals, where exploration and exploitation are considered simultaneously.

Abstract: The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the CXCR4 pathway.

Abstract: The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis.

Abstract: The application provides a high energy density fuel cell apparatus and system with at least one hydride-based hydrogen generator. The system includes an array of fuel cells that are arranged either in parallel or series. The system also includes a water storage vessel, which has a single stage hydrolysis reaction zone for hydrolyzing magnesium hydride. The hydrolysis reaction mechanism is based on the exothermic MgH2 hydrolysis reaction pathway. The system further includes a reactor vessel, a water pump disposed between the water storage vessel and the reactor vessel, and a check valve disposed in a discharge line connecting the water pump to the reactor vessel. The hydride-based hydrogen generators (single or multiples) are arranged either in parallel or series. The fuel cells, the water storage vessel and the reactor vessel are in fluid communication. Furthermore, the discharge line comprises a tubing with a predetermined rupture pressure range.

Abstract: The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis.

Abstract: A system with deep reinforcement learning based control determines optimal actions for major components in a commercial building to minimize operation costs while maximizing comprehensive comfort levels of occupants. An unsupervised deep Q-network method is introduced to handle the energy management problem by evaluating the influence of operation costs on comfort levels considering the environment factors at each time slot. An optimum control decision can be derived that targets both immediate and long-term goals, where exploration and exploitation are considered simultaneously.

Abstract: The present disclosure provides a method for performing clustering on operation modes of a power system based on a sparse autoencoder. The method includes: obtaining related data of the power system; setting a training parameter, a number of hidden layers, and a number of neurons; training an autoencoder model using the related data and extracting a topological structure and a weight matrix from the model; performing cluster analysis to obtain a number of typical scenarios; and performing decoding to obtain original data at centers of respective scenarios. The present disclosure can achieve fast selection and dimensionality reduction of feature vectors representing operation modes of a power system. In view of this, the present disclosure provides a novel idea and method for selecting a feature vector representing an operation mode of a power system and generating a typical operation scenario.

Abstract: Disclosed are compositions and methods for the electrochemical detection of enzymes, such as enzymes that are indicative of disease, disorders, or pathogens, such as viruses, bacteria, and fungi, or other disorders. These methods can be used in point-of-care diagnostic assays for the detection of disease, disorder, or pathogen (e.g., to identify the strain of pathogen infecting a patient in a healthcare setting). The electrochemical methods described herein can also be used to assess the susceptibility of a pathogen to an antipathogen drug. Also provided are probes suitable for use in conjunction with the methods described herein.

Abstract: The present application proposes an air purification device with filter cartridge self-cleaning, which includes: cabinet, air filter cartridge and centrifugal fan, a first mounting plate and a second mounting plate are arranged in the interior of the cabinet from top to bottom, the first mounting plate and the second mounting plate divide the interior of the cabinet into a first chamber, a second chamber, and a third chamber, the cabinet is provided with an air inlet communicating with the first chamber, and with a plurality of air outlets communicating with the third chamber; the air filter cartridge is arranged in the second chamber, the air filter cartridge includes an end cover, a bottom cover and a filter cylinder, and the two ends of the filter cylinder are respectively connected with the end cover and the bottom cover, and the filter cylinder is used for filtering and purifying the air, a cleaning assembly is arranged in the filter cylinder for removing dust adsorbed on the filter cylinder; the centrif

Abstract: Systems and method are disclosed for monitor long-term voltage stability in a power system by estimating post-contingency operating point(s) considering PV-PQ transitions based on the current operating point; predicting a sensitivity based Thevenin index (STI) for each contingency using the estimated operating condition; and determining a voltage stability assessment (VSA) considering N?1 contingency.

Abstract: The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis.

Abstract: Systems and methods for autonomous line flow control in an electric power system are disclosed which includes acquiring state information at a line in the electric power system at a first time step, obtaining a flow data of the line at a next time step based on the acquired state information, generating an early warning signal when the obtained flow data is higher than a predetermined threshold, activating a deep reinforcement learning (DRL) agent to generate an action using a DRL algorithm based on the state information, and executing the action to adjust a topology of the electric power system.

Abstract: A hydrogen generator can include, in some aspects, a reaction chamber configured to contain a reagent; a supply water tank; water conduit tubing provided inside the reaction chamber, the water conduit tubing including a water conduit tubing inlet being fluidically connected to the supply water tank and a water conduit tubing outlet; a water dispenser provided inside the reaction chamber, the water dispenser including a water dispenser inlet being fluidically connected to the water conduit tubing outlet and a surface with a plurality of water outlet channels; a water pump; an electric power supply; a controller adapted to activate the water pump for transferring water through the hydrogen generator for interacting with the reagent in the reaction chamber to generate hydrogen gas, and a hydrogen collector provided inside the reaction chamber, the hydrogen collector including a surface with a plurality of gas inlet channels for receiving the hydrogen gas.

Abstract: A chiral heterocyclic compound with hedgehog pathway antagonist activity, method and use thereof are provided. The chiral heterocyclic compound with hedgehog pathway antagonist activity has the structure represented by formula I. A pharmaceutical composition and combined application composition are also provided. Novel molecules of formula II that inhibit hedgehog pathway signaling and therapeutic applications for the treatment of malignancies, prevention of tumor regrowth, sensitization of radio-chemo therapies, and other diseases related to hedgehog signaling are also provided.