Abstract: The hedgehog (Hh) signaling pathway is a pathway which regulates patterning, growth and cell migration during embryonic development, but in adulthood is limited to tissue maintenance and repair. Mutational inactivation of the inhibitory pathway components leads to constitutive ligand-independent activation of the Hh signaling pathway, results in cancers such as basal cell carcinoma and medulloblastoma. Ligand-dependent activation of Hh signaling is involved in prostate cancer, pancreatic cancer, breast cancer and some blood cancers. Therefore, inhibition of the aberrant Hh signaling represents a promising approach toward novel anticancer therapy. The present invention provides novel molecules of formula I that inhibit hedgehog pathway signaling and provides therapeutic applications for the treatment of malignancies (basal cell carcinoma, medulloblastoma, glioblastoma, non-small cell lung cancer, prostate cancer, pancreatic cancer, blood cancers, mesenchymal cancers, etc.

Abstract: Disclosed are compositions and methods for the electrochemical detection of enzymes, such as enzymes that are indicative of disease, disorders, or pathogens, such as viruses, bacteria, and fungi, or other disorders. These methods can be used in point-of-care diagnostic assays for the detection of disease, disorder, or pathogen (e.g., to identify the strain of pathogen infecting a patient in a healthcare setting). The electrochemical methods described herein can also be used to assess the susceptibility of a pathogen to an antipathogen drug. Also provided are probes suitable for use in conjunction with the methods described herein.

Abstract: The hedgehog (Hh) signaling pathway is a pathway which regulates patterning, growth and cell migration during embryonic development, but in adulthood is limited to tissue maintenance and repair. Mutational inactivation of the inhibitory pathway components leads to constitutive ligand-independent activation of the Hh signaling pathway, results in cancers such as basal cell carcinoma and medulloblastoma. Ligand-dependent activation of Hh signaling is involved in prostate cancer, pancreatic cancer, breast cancer and some blood cancers. Therefore, inhibition of the aberrant Hh signaling represents a promising approach toward novel anticancer therapy. The present invention provides novel molecules of formula I that inhibit hedgehog pathway signaling and provides therapeutic applications for the treatment of malignancies (basal cell carcinoma, medulloblastoma, glioblastoma, non-small cell lung cancer, prostate cancer, pancreatic cancer, blood cancers, mesenchymal cancers, etc.

Abstract: The present invention relates to the use of novel compounds of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: A ground-based videometrics guiding method for aircraft landing or unmanned aerial vehicles recovery is provided. The method comprised the following steps: setting videos(1,2,3,4,5,6) near the landing area of the aircraft or unmanned aerial vehicles; real-time imaging the aircraft or unmanned aerial vehicles during their final approaches; and real-time measuring the trajectory, velocity, acceleration, post and other motion parameters of the aircraft or unmanned aerial vehicles by analyzing the video images and using videometrics technology, so as to provide guiding information for the aircraft landing or unmanned aerial vehicles recovery.

Abstract: The present invention relates to the use of novel thiazolopyrimidine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: A folding optical path transfer videometrics method for measuring the three-dimensional position and attitude of non-intervisible objects is disclosed. In one aspect, the method includes the following: constructing a folding optic path between an invisible target and a reference, disposing transfer station comprising a camera, a cooperating mark and a laser range finder on each break point in the folding optic path. The method may further include processing an image shot by each camera, accounting for the distance measured by the laser range finder, obtaining a position and posture information corresponding to each adjacent transfer station, summing the values from the reference to the invisible target, and achieving three-dimensional position and posture of the invisible target relating to the reference.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of the compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.

Abstract: The present invention relates to the use of novel triazolopyridine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Abstract: Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.

Abstract: The present invention provides a ground-based camera surveying and guiding method for aircraft landing and unmanned aerial vechicle recovery based on the camera surveying technology, which is a ground-based camera surveying and guiding system mainly including several video cameras arranged near the landing areas of an aircraft or an unmanned aerial vechicle. During the approaching process of the aircraft or the unmanned aerial vechicle, the system performs imaging of the aircraft in real time and detects movement parameters such as the track, velocity, acceleration, attitude and the offset relative to the glide slope of the aircraft or the unmanned aerial vechicle in real time by analyzing images and applying camera surveying method and technology, so as to provide guidance for aircraft landing or unmanned aerial vechicle recovery. The method is an autonomic guiding survey without interferences from others, which has high accuracy and reliability. The hardware devices are mature, simple and have low cost.

Abstract: An improved interface circuit is provided herein for translating a relatively high input voltage into a relatively low output voltage using only low voltage transistors and a single, low voltage power supply. According to one embodiment, the interface circuit includes a power supply, a pair of input transistors with source terminals coupled together for receiving a relatively low voltage from the power supply, and a current sense amplifier with a pair of input terminals, each coupled to a drain terminal of a different one of the pair of input transistors for receiving a pair of differential currents and for generating a pair of differential voltages therefrom.

Abstract: Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Abstract: Compounds of formula (I): wherein R1, R2 and R3 are as defined herein, including pharmaceutically acceptable salt, ester, solvate or stereoisomer thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof.

Abstract: A folding optical path transfer videometrics method for measuring the three-dimensional position and attitude of non-intervisible objects is disclosed. In one aspect, the method includes the following: constructing a folding optic path between an invisible target and a reference, disposing transfer station comprising a camera, a cooperating mark and a laser range finder on each break point in the folding optic path. The method may further include processing an image shot by each camera, accounting for the distance measured by the laser range finder, obtaining a position and posture information corresponding to each adjacent transfer station, summing the values from the reference to the invisible target, and achieving three-dimensional position and posture of the invisible target relating to the reference.

Abstract: A driver circuit is provided herein. In general, the driver circuit includes a driver portion, a common mode feedback portion and a current replication portion. The feedback portion receives a common mode voltage (vcm) from the driver portion and an alternative common mode voltage (vcm_alt) from the current replication portion. The feedback portion selects one of the common mode voltages for comparison with a reference voltage and generates a feedback bias signal (vcmfb) based on a voltage difference there between. When the driver circuit is enabled, the actual common mode voltage (vcm) is used to maintain the output common mode voltage around the reference voltage. When the driver circuit is disabled, the alternative common mode voltage (vcm_alt) is used to keep the bias signal (vcmfb) from drifting away.