Abstract: The disclosure relates to the field of new energy vehicle testing, in particular to a virtual evaluation method and device for actual road energy consumption of new energy vehicles.

Abstract: Provided are a fusion protein that improves gene editing efficiency and an application thereof. The fusion protein comprises a single-stranded DNA binding protein functional domain, nucleoside deaminase and nuclease. According to CBEs, when carrying our base conversion from C-G to T-A, nucleoside deaminase such as cytosine deaminase carries out deamination by using single-stranded DNA as a substrate, and by re-fusing the single-stranded DNA binding protein functional domain on the fusion protein of the nucleoside deaminase and nuclease, the chance of single-stranded DNA being exposed to the nucleoside deaminase is greatly increased, thereby significantly improving base editing efficiency. The present disclosure provides a breakthrough improvement of single-base gene editing technology and can greatly promote the application thereof in aspects such as gene editing, gene therapy, cell therapy, animal model making, and crop genetic breeding.

Abstract: The present disclosure provides a fusion protein capable of improving base editing activity and reducing an off-target level, and relates to the technical field of biological technologies. In the present disclosure, a degradation system based on a tDeg fusion protein is first introduced into a base editing system to obtain a novel base editing system capable of improving the base editing efficiency while reducing the off-target level. Further, a degron sequence and a RNA-binding polypeptide are fused with a base editing module of a base editor to form a fusion protein and meanwhile Pepper RNA is introduced into a loop region of sgRNA, so as to obtain the base editing system of the present application. The base editing system with high efficiency and low off-target rate constructed in the present disclosure will further promote wide base editing tool application, especially in gene therapy and clinical disease treatment.

Abstract: A T cell receptor targeting a KRAS G12V mutant polypeptide and a use thereof, wherein the T cell receptor molecule specifically targets a KRAS G12V mutation; a CDR3 sequence of an ? chain variable domain thereof contains CAVRDIEGAGNNRKLIW (SEQ ID NO: 1) or a mutant of SEQ ID NO: 1, and/or a CDR3 sequence of a ? chain variable domain contains CASSEGQYSYEQYF (SEQ ID NO: 2) or a mutant of SEQ ID NO: 2. Furthermore, a nucleic acid molecule encodes the T cell receptor molecule, a dual-targeting protein molecule and a multivalent complex includes the T cell receptor molecule, a nucleic acid construct, a cell expressing the T cell receptor molecule, etc.

Abstract: Provided are a security control method and apparatus for a power communication network, a central coordinator (CCO), and a node. A CCO initially sets a security mode of a power communication network to an unencrypted mode. In the unencrypted mode, a first network access request of a station (STA) is received, where the first network access request carries a communication type of the STA. Whether to enable an encrypted mode is determined based on a communication type of each STA in the power communication network. When there is a multi-mode node in the power communication network, the security mode of the power communication network is set to the encrypted mode. This realizes compatibility between the single-mode node and the multi-mode node, achieves security control, improves secure communication between the CCO and the STA, and implements a direct secure anti-eavesdropping solution between the CCO and the STA.

Abstract: A graphene copper composite material preparation method based on a combination of hot pressing sintering and chemical vapor deposition, comprising: presetting multi-layer copper foil in a hot pressing chamber; preparing a graphene thin film on the surface of the copper foil by means of a chemical vapor deposition method to obtain a graphene copper composite material; and then performing hot pressing forming on the multi-layer graphene copper foil material to prepare the graphene copper composite material. Said material can replace a traditional copper material or silver material, is applied to a supercapacitor or a motor driving device, and has the effects of improving efficiency, reducing temperature rise, etc.

Abstract: A tank body device for measuring slurry density of thermal power generation slurry is provided. Particularly, the tank body includes a clamping assembly, a clinging assembly, and a plurality of push assembly. The clamping assembly, with a base case and closing members, securely holds the tank body. The clinging assembly, featuring telescopic members, articulation pieces, and clamping rings, provides additional support and ensures stability. Each push assembly includes a moving part, push member, and first spring, all integrated into the system. This arrangement enables automatic realignment of the tank body when it tilts, reducing the workload for plant staff and ensuring precise measurement of weight and pressure values.

Abstract: This application relates to the technical field of biological products, and provides an application, extraction method and composition of TGL-ELNs in the treatment of glioma. The TGL-ELNs are applied in any one or more of the following aspects: a) Preparation of products for promoting apoptosis of glioma cells; b) Preparation of products for inhibiting proliferation of glioma cells; c) Preparation of products for inhibiting autophagy of glioma cells; d) Preparation of products for treating glioma. Verified through cell and animal experiments, the TGL-ELNs in this application can effectively induce apoptosis of glioma cells and inhibit autophagy of glioma cells to induce glioma cell death, and act on glioma cells through the AKT/mTOR signaling pathway and by inhibiting the production of autophagosomes in glioma cells.

Abstract: An interactive phone holder and intelligent interaction method, the method includes the steps of generating a control signal by a phone and performing a corresponding emotional expression group by the phone and the phone holder which cooperate with each other, wherein the emotional expression group includes: displaying at least one of expression pattern and expression animation by the phone, performing at least one basic action by the phone holder, and adjusting a status of an information indicator light on said phone holder in one or more ways.

Abstract: A camera monitoring method includes when a trigger condition for entering a privacy mode is met, adjusting a hardware parameter of a camera to a preset hardware parameter, and using the camera with an adjusted hardware parameter to monitor a target scene in a privacy mode. A clarity of an image captured by the camera under the preset hardware parameter is lower than a clarity of an image captured by the camera in a focused state.

Abstract: The present invention discloses a method for monitoring and early warning of wild plant distribution status based on image recognition, relating to the technical field of monitoring and early warning of wild plant distribution status. This method promotes the scientific assessment of ecological protection status of each sub-area by calculating coverage indexes Fgl and population complexity indexes When one of the coverage indexes or the population complexity indexes of a sub-area does not reach a preset threshold, an unqualified mark is marked accordingly. By calculating environmental pressure indexes HJyl, a first early warning instruction is automatically sent when one of the environmental pressure indexes HJyl exceeds a preset first pressure threshold, indicating that the environmental pollution status is unqualified.

Abstract: Disclosed herein are an image processing method and apparatus, an electronic device and a storage medium. The method includes: obtaining an image (S110); receiving a template triggering operation for the image and displaying at least one template each comprising at least one template element (S120); and receiving a template selection operation for the template, and displaying a target effect image by applying a selected template to the image, wherein a target display mode of at least part of template elements is different from a default display mode of the at least part of the template elements (S130).

Abstract: The invention relates to the field of fish tank cleaning, in particular discloses a water exchanger. The water exchanger comprises a pressing balloon, a switch valve, a communicating pipe, a connecting pipe, a cleaning brush head and a water outlet joint. The cleaning brush head is equipped with multiple cleaning bristles and water inlet holes. Through the invention, the user can use one hand to press the pressing balloon to absorb water and rotate the switch valve to adjust the size of the water outlet channel and control the water flow rate. The user can use his spare hand to assist with water absorption or handle emergencies. Therefore, the use of the invention is more flexible and convenient.

Abstract: The present invention relates to a composite material for improving metal conductivity and a method of preparing the same. The composite material includes a composite of n A-B-A structures, where A is a graphene fragment layer, B is a metal foil layer, and n is an integer greater than or equal to 2; and the graphene fragment layer includes graphene fragments uniformly laid flat on the metal foil layer. The conductivity of the conventional metal material is increased by at least 18%, and the conductivity of the conventional metal material in a bending state remains almost the same as in a normal state.

Abstract: The disclosure relates to the technical field of detection devices, and provides a carved code quality detection apparatus and system, wherein the carved code quality detection apparatus includes: a support assembly, including a guide rod, a baffle and a first support plate, the guide rod extending along the height direction, the baffle being fixedly connected to the upper end of the guide rod, and the first support plate being fixedly connected to the lower end of the guide rod; a visual detection system, including an imaging assembly movably connected to the guide rod; and a driving assembly, arranged on the baffle and connected to the imaging assembly, the driving assembly being configured to drive the imaging assembly. The technical solutions can achieve online detection of the carved code quality of a member to be detected, thereby reducing the risk of false detection or missed detection caused by manual visual inspection.