Abstract: Provided are a fusion protein that improves gene editing efficiency and an application thereof. The fusion protein comprises a single-stranded DNA binding protein functional domain, nucleoside deaminase and nuclease. According to CBEs, when carrying our base conversion from C-G to T-A, nucleoside deaminase such as cytosine deaminase carries out deamination by using single-stranded DNA as a substrate, and by re-fusing the single-stranded DNA binding protein functional domain on the fusion protein of the nucleoside deaminase and nuclease, the chance of single-stranded DNA being exposed to the nucleoside deaminase is greatly increased, thereby significantly improving base editing efficiency. The present disclosure provides a breakthrough improvement of single-base gene editing technology and can greatly promote the application thereof in aspects such as gene editing, gene therapy, cell therapy, animal model making, and crop genetic breeding.

Abstract: Disclosed is an artificial intelligence infrared thermal imaging bra system with breast disease detecting function. The system includes a side support, two chest support layers and two shoulder straps; the two shoulder straps are fixed at both ends of the side support, and the two chest support layers are symmetrically fixed between the two shoulder straps at the top of the side support; the two chest support layers are internally provided with sliding mechanisms that are adjustable according to different chests of users; a rotating mechanism for driving the sliding mechanisms to move is arranged between the two chest support layers at the top of the side support, and the rotating mechanism and the sliding mechanisms are in transmission connection; one end of the side support is fixed with a sub-buckle, and the other end of the side support is provided with a stretching mechanism.

Abstract: A running deck assembly and a treadmill are provided. The running deck assembly includes: a front running deck; a rear running deck, wherein a front end face of the rear running deck is hinged with a rear end face of the front running deck by a hinge, and a hinging gap is located at a location where the front running deck is hinged to the rear running deck; an annular running belt, which is rotatably mounted around the front running deck and the rear running deck with a clearance; and a flexible layer, which is laid on an upper surface of the front running deck and an upper surface of the rear running deck and covers the hinging gap.

Abstract: A precise coordination control system includes a trajectory generator, a closed-loop system of a first motion stage, and a closed-loop system of a second motion stage. The precise coordination control method includes: initializing an iteration experiment count j to 1 and feedforward control signals of two motion stages to 0; performing the jth iteration experiment and running the coordination control system; updating the feedforward control signals of the two motion stages; and continuing next iteration and stopping the iteration experiment until a coordination motion error meets a precision requirement. Both of respective servo errors of two motion stages and the coordination motion error of the two motion stages can be reduced. A learning coefficient is designed by using an adaptive method to provide an increased convergence rate, high robustness to external random disturbances, and good anti-disturbance capability.

Abstract: A running deck assembly and a treadmill are provided. The running deck assembly includes: a front running deck; a rear running deck, wherein a front end face of the rear running deck abuts a rear end face of the front running deck; a flexible layer, laid on an upper surface of the front running deck and an upper surface of the rear running deck; and an annular running belt, rotatably mounted around the front running deck and the rear running deck with a clearance.

Abstract: Provided are antibodies that specifically recognize B7 homology 3 protein (B7-H3).

Abstract: The present invention relates to a fusion protein for enhancing gene editing and use thereof. In particular, the invention provides an enhanced fusion protein. The enhanced fusion proteins of the present invention can significantly increase gene editing efficiency in vivo or in vitro as compared to the wildtype gene editing protein.

Abstract: The present invention discloses a micro-capsule type silicon-carbon composite negative electrode material, and the negative electrode material comprises a current collector and a silicon-carbon coating layer formed by drying silicon-carbon paste coating the current collector; the silicon-carbon slurry comprises a carbonaceous paste and silicon capsule powder dispersed in the carbonaceous paste; the carbonaceous paste comprises a dispersing agent, and a carbon material, a first conductive agent and a first binder dispersed in the dispersing agent; the silicon capsule powder has micro-capsule structures comprising silicon powder and a second binder coating the surface of the silicon powder and in which the silicon powder is a core and the second binder is an outer shell; and the first binder is different from the second binder. The improved silicon-carbon composite negative electrode material of the present disclosure has excellent effects in cycle performance, coulombic efficiency and rate capability.

Abstract: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility.

Abstract: The present application discloses a home appliance control authority sharing method. The method includes: receiving a control sharing operation and obtaining authority setting rules corresponding to the control sharing operation; generating a control authority of a terminal to be shared based on the authority setting rule; sharing the control authority to the terminal to be shared so that the terminal to be shared can control the home appliance according to the control authority set by the authority setting rule. The present application also discloses a control terminal, a home appliance and a storage medium.

Abstract: An air-conditioning device control method includes receiving an instruction sent by a terminal device, judging whether the instruction comes from a preset local area network, identifying a user identity according to the instruction in response to the instruction coming from the preset local area network, acquiring an operation mode of an air-conditioning device that is adapted to the user identity, and executing the operation mode of the air-conditioning device.

Abstract: Provided are antibodies that recognize the B-Cell Maturation Antigen (BCMA) and methods of use thereof.

Abstract: The present disclosure discloses an optical imaging lens group including, sequentially from an object side to an image side along an optical axis, a first lens, a second lens, a third lens, a fourth lens, a fifth lens and a sixth lens, each of which has refractive power. An object-side surface of the first lens is a convex surface, and an image-side surface of the first lens is a concave surface; an image-side surface of the second lens is a concave surface; and an object-side surface of sixth lens is a concave surface. A distance TTL along the optical axis from an object-side surface of the first lens to an imaging plane of the optical imaging lens group and half of a diagonal length ImgH of an effective pixel area on the imaging plane of the optical imaging lens group satisfy TTL/ImgH?1.23.

Abstract: An optical imaging lens includes a first lens element, a second lens element, a third lens element, and a fourth lens element from an object side to an image side in order along an optical axis. The first lens element to the fourth lens element each include an object-side surface facing the object side and allowing imaging rays to pass through and an image-side surface facing the image side and allowing the imaging rays to pass through. The object-side surface of the second lens element has a concave portion in a vicinity of the optical axis. The image-side surface of the second lens element has a convex portion in a vicinity of a periphery of the second lens element. The object-side surface of the third lens element has a concave portion in a vicinity of a periphery of the third lens element. The fourth lens element has negative refracting power.

Abstract: Provided are two split single-base gene editing systems. Intein-mediated split BE3, saKKH-BE3 and ABE7.10 are separately developed by using the existing protein structure information of spCas9 and saCas9 and splitting methods thereof, and have targeted gene mutation efficiency equivalent to that of unsplit BE3, saKKH-BE3 and ABE7.10 working system, thereby making possible package into an AAV for delivery.

Abstract: A portable supercritical fluid extraction apparatus, comprising: (i) a pressure vessel for generating a supercritical fluid therein; (ii) a liquid solvent supply tank; (iii) a means for interconnecting said pressure vessel and said liquid solvent supply tank at a predetermined angle for delivery therethrough of a liquid solvent from the liquid storage tank to the pressure vessel; and (iv) a heating component for heating contents of the pressure vessel to produce a supercritical fluid therein. The apparatus may additionally comprise a sample in fluid communication with the pressure vessel, and a receiving vessel in fluid communication with the pressure vessel. The pressure vessel may have a heating means for heating fluid contents therein, for example a heating wrap, a heating block, or a heating jacket.