Abstract: A champagne tower-type multi-stage throttle control valve includes a valve body, a valve cover, a throttle sleeve, and a valve core. A sleeve cavity of the throttle sleeve is shaped as a stepped hole with two or more layers. The valve core is shaped as a stepped shaft with two or more layers coaxial with the throttle sleeve. The number of shaft shoulders of the valve core is smaller than or equal to the number of hole shoulders of the sleeve cavity of the throttle sleeve, such that each set of shaft shoulders of the valve core in an axial direction can form a sealing surface fit with corresponding hole shoulders of the throttle sleeve. A flow channel groove is axially or obliquely formed on each of the hole shoulders of the throttle sleeve and/or the shaft shoulders of the valve core.

Abstract: Microneedle arrays for introducing an active ingredient through a skin surface of a subject can include a base layer, a plurality of microneedles projecting from the base layer, and an active ingredient. Each of the microneedles comprises an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles comprises at least one dissolvable polymer. The active ingredient is incorporated in the elongate body, and the active ingredient is present only in the distal portion and at least internally in the distal portion.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract: A linkage device includes a drive component and a support member. The drive component is rotatable during a transmission stroke and an idle stroke. The support member is coupled to the drive component. The drive component and the support member rotate synchronously during the transmission stroke. At least a part of the drive component idles with respect to the support member during the idle stroke. The support member has a retracted position and a support position switched by the transmission stroke. The support member in the retracted position is suitable for storage. The support member in the support position is suitable for stopping and limiting.

Abstract: Microneedle arrays for introducing an active ingredient through a skin surface of a patient can include a base layer, a plurality of microneedles projecting from the base layer, and a shell layer having an active ingredient. Each of the microneedles includes an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles can also include at least one dissolvable polymer. The active ingredient is incorporated in the shell layer, which extends around at least a portion of the elongate body.

Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

Abstract: The present disclosure provides dermal fillers comprising hyaluronic acid-based hydrogels. The hydrogels are coacervates formed through ionic interactions between anionic polysaccharides, such as hyaluronic acid, and cationic polysaccharides, such as chitosan. The dermal fillers are useful for augmenting soft tissues, reducing soft tissue defects and improving skin quality.

Abstract: An accommodating cylinder, a touch pen assembly, and a protective case are provided. The accommodating cylinder includes a cylinder body, a first magnetic member, a second magnetic member and a pen base. The cylinder body has an accommodating cavity. The first magnetic member is configured to generate a first magnetic field, and is arranged in the accommodating cavity. At least one of the first magnetic member and the second magnetic member is a coil, and the second magnetic member is arranged in the accommodating cavity and movable between a retracted position and an extended position. The pen base is connected with the second magnetic member. The second magnetic member is configured to move relative to the first magnetic member from the retracted position to the extended position, and to drive the pen base to move from an inserted position to a pop-up position in a first power-on state.

Abstract: The disclosure relates to compositions comprising crosslinked hyaluronic acid physically mixed with collagen. Also contemplated are methods of improving an aesthetic quality of an anatomic feature of a human being.

Abstract: The present disclosure relates to a crosslinked macromolecular matrix comprising lysine; hyaluronic acid; and collagen; wherein the hyaluronic acid is crosslinked to the collagen by at least one endogenous amine group on the collagen and/or by at least one amine group present on the lysine.

Abstract: An accommodating cylinder, a touch pen assembly, and a protective case are provided. The accommodating cylinder includes a cylinder body, a first magnetic member, a second magnetic member and a pen base. The cylinder body has an accommodating cavity. The first magnetic member is configured to generate a first magnetic field, and is arranged in the accommodating cavity. At least one of the first magnetic member and the second magnetic member is a coil, and the second magnetic member is arranged in the accommodating cavity and movable between a retracted position and an extended position. The pen base is connected with the second magnetic member. The second magnetic member is configured to move relative to the first magnetic member from the retracted position to the extended position, and to drive the pen base to move from an inserted position to a pop-up position in a first power-on state.

Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

Abstract: Microneedle arrays for introducing an active ingredient through a skin surface of a subject can include a base layer, a plurality of microneedles projecting from the base layer, and an active ingredient. Each of the microneedles comprises an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles comprises at least one dissolvable polymer. The active ingredient is incorporated in the elongate body, and the active ingredient is present only in the distal portion and at least internally in the distal portion.

Abstract: The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

Abstract: Microneedle arrays for introducing an active ingredient through a skin surface of a subject can include a base layer, a plurality of microneedles projecting from the base layer, and an active ingredient. Each of the microneedles comprises an elongate body having a proximal portion and a distal portion, in which the proximal portion is attached to the base layer. Each of the microneedles comprises at least one dissolvable polymer. The active ingredient is incorporated in the elongate body, and the active ingredient is present only in the distal portion and at least internally in the distal portion.

Abstract: Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions which are particularly advantageous for correction of fine lines in the face.