Abstract: A non-small cell lung cancer target ARID1A and an inhibitor thereof can be used in the preparation of a drug for treating lung cancer. A glycolysis inhibitor is used for preparing a composition or a preparation. The composition or the preparation is used for: (a) preventing and/or treating lung cancer, wherein the lung cancer is an ARID1A-negative lung cancer, and/or (b) inhibiting lung cancer cells, wherein the lung cancer cells are ARID1A-negative lung cancer cells.

Abstract: System and methods of this technology can provide a framework using machine learning based message generator. The framework can retrieve elapsed times according to computing devices executing an application. Once the elapsed times are retrieved, the framework can generate a total elapsed time that can indicate an average amount of time captured by the at least one computing devices. The framework can make a determination based on the total elapsed time and a threshold elapsed time. The threshold elapsed time can be generated from data associated with previous months, years, days, among other time periods. Upon determining that the total elapsed time is higher than the threshold elapsed time, the framework can generate instructions to display the metrics associated with the total elapsed time, on another computing device.

Abstract: Porous catalyst support and methods for producing same are provided herein. An example porous catalyst support includes a porous material defining a plurality of pores, wherein the porous material comprises a porous carbon material, the plurality of pores comprises a plurality of micropores and a plurality of mesopores, and a porosity of the porous catalyst has a predetermined volume of micropores and of mesopores.

Abstract: Managing and applying human resources data comprising aggregating employee transaction data for an organization. A number of human resources-related attributes are evaluated across heterogeneous transaction data. The employee transaction data is classified via statistical machine learning into a number of normalized codes according to the human resources-related attributes, a user interface is presented to adjust a number of organizational operating procedures according to the normalized codes.

Abstract: A lithium battery module including a housing, a cover, at least one lithium battery cell and a fire retardant material is provided. The cover covers the housing. The housing and the cover form an accommodating space. The lithium battery cell is disposed in the accommodating space. The fire retardant material is filled in the accommodating space.

Abstract: Managing and applying human resources data comprising aggregating employee transaction data for an organization. A number of human resources-related attributes are evaluated across heterogeneous transaction data. The employee transaction data is classified via statistical machine learning into a number of normalized codes according to the human resources-related attributes, a user interface is presented to adjust a number of organizational operating procedures according to the normalized codes.

Abstract: Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same.

Abstract: Provided are functional segregated telodendrimers having, for example, two or three functional segments. The telodendrimers can aggregate to form nanocarriers. The telodendrimers can have one or more tetracycline drugs (such as CMT-3) physically bound thereto that release under physiological conditions. Such nanocarriers with loaded CMT-3 disperse stably in aqueous solution and may be used in treating inflammatory disease through local or systemic administration. Also provided are methods of treating acute respiratory distress syndrome (ARDS) and/or CARDS in a subject in need thereof, including: administering a therapeutically effective amount of CMT-3 and one or more nonantimicrobial host-modulators directly to the lungs of the patient. In embodiments, CMT-3 is administered to the lungs in an aerosolized formulation. In embodiments, subsequent to CMT-3 administration, one or more non-antimicrobial host-modulators directly to the lungs of the patient.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

Abstract: Various amide compounds that bind Cbl-B, including those that are selective for C-Cbl, and methods of making and using the same.

Abstract: A Bacillus velezensis (B. velezensis) strain bred through ultrasound-assisted adaptive evolution and use thereof are provided. In the present disclosure, a B. velezensis strain (B. velezensis CICC 23571) is used as a starting strain, and an ultrasound-assisted adaptive evolution process is performed, where a proportion of organic nitrogen in a medium is continuously reduced and proportions of inorganic nitrogen and a sugar source are increased to obtain a B. velezensis mutant strain with a high polypeptide yield. Different metabolic pathways in the mutant strain are enhanced, such that the mutant strain can efficiently convert inorganic nitrogen into organic nitrogen or reduce the deaminization of organic nitrogen, and finally a yield of polypeptides is greatly increased.

Abstract: A lithium battery module including a housing, a cover, at least one lithium battery cell and a fire retardant material is provided. The cover covers the housing. The housing and the cover form an accommodating space. The lithium battery cell is disposed in the accommodating space. The fire retardant material is filled in the accommodating space.

Abstract: A polymer having a dispersing function, a preparation method therefor and use thereof as a cement dispersant are provided. The polymer has a structural unit (a), a structural unit (b) and a structural unit (c). The structural unit (a) is provided by an unsaturated polyether, the structural unit (b) is provided by an unsaturated acid and/or a salt thereof and/or an anhydride thereof, and the structural unit (c) is provided by a silane and/or siloxane having a polymerizable group and no less than five carbon atoms. The molar ratio of the structural unit (a), the structural unit (b) and the structural unit (c) is 1:(1-20):(0.01-0.5); and the polymer has a weight average molecular weight of 20,000-90,000 g/mol.

Abstract: Provided herein are combination therapies comprising GDC-9545 and GDC-0077 for treating locally advanced breast cancer or metastatic breast cancer.

Abstract: Provided herein are combination therapies comprising GDC-9545 and abemaciclib or ribociclib for treating locally advanced breast cancer or metastatic breast cancer.

Abstract: Managing and applying human resources data comprising aggregating employee transaction data for an organization. A number of human resources-related attributes are evaluated across heterogeneous transaction data. The employee transaction data is classified via statistical machine learning into a number of normalized codes according to the human resources-related attributes, a user interface is presented to adjust a number of organizational operating procedures according to the normalized codes.