Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

Abstract: Various amide compounds that bind Cbl-B, including those that are selective for C-Cbl, and methods of making and using the same.

Abstract: A Bacillus velezensis (B. velezensis) strain bred through ultrasound-assisted adaptive evolution and use thereof are provided. In the present disclosure, a B. velezensis strain (B. velezensis CICC 23571) is used as a starting strain, and an ultrasound-assisted adaptive evolution process is performed, where a proportion of organic nitrogen in a medium is continuously reduced and proportions of inorganic nitrogen and a sugar source are increased to obtain a B. velezensis mutant strain with a high polypeptide yield. Different metabolic pathways in the mutant strain are enhanced, such that the mutant strain can efficiently convert inorganic nitrogen into organic nitrogen or reduce the deaminization of organic nitrogen, and finally a yield of polypeptides is greatly increased.

Abstract: A lithium battery module including a housing, a cover, at least one lithium battery cell and a fire retardant material is provided. The cover covers the housing. The housing and the cover form an accommodating space. The lithium battery cell is disposed in the accommodating space. The fire retardant material is filled in the accommodating space.

Abstract: A polymer having a dispersing function, a preparation method therefor and use thereof as a cement dispersant are provided. The polymer has a structural unit (a), a structural unit (b) and a structural unit (c). The structural unit (a) is provided by an unsaturated polyether, the structural unit (b) is provided by an unsaturated acid and/or a salt thereof and/or an anhydride thereof, and the structural unit (c) is provided by a silane and/or siloxane having a polymerizable group and no less than five carbon atoms. The molar ratio of the structural unit (a), the structural unit (b) and the structural unit (c) is 1:(1-20):(0.01-0.5); and the polymer has a weight average molecular weight of 20,000-90,000 g/mol.

Abstract: Provided herein are combination therapies comprising GDC-9545 and GDC-0077 for treating locally advanced breast cancer or metastatic breast cancer.

Abstract: Provided herein are combination therapies comprising GDC-9545 and abemaciclib or ribociclib for treating locally advanced breast cancer or metastatic breast cancer.

Abstract: Managing and applying human resources data comprising aggregating employee transaction data for an organization. A number of human resources-related attributes are evaluated across heterogeneous transaction data. The employee transaction data is classified via statistical machine learning into a number of normalized codes according to the human resources-related attributes, a user interface is presented to adjust a number of organizational operating procedures according to the normalized codes.

Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

Abstract: Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same.

Abstract: Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: The present disclosure provides a grayscale compensation method, a gray-scale compensation assembly, and a liquid crystal display device. The gray-scale compensation method includes: detecting a display region for compensation in the liquid crystal display screen that needs grayscale compensation under a reserved liquid crystal response time; acquiring a grayscale conversion timetable of the liquid crystal display screen, and obtaining a limit value of conversion time of the liquid crystal display screen according to the grayscale conversion timetable; acquiring a compensation grayscale lookup table of the display region for compensation; comparing the reserved liquid crystal response time and the limit value of conversion time to obtain a time comparison result; performing grayscale compensation on the display region according to the time comparison result, the grayscale conversion timetable and the compensation grayscale lookup table.

Abstract: The present disclosure provides a grayscale compensation method, a grayscale compensation assembly, and a liquid crystal display device. The grayscale compensation method includes: detecting a display region for compensation in the liquid crystal display screen that needs grayscale compensation under a reserved liquid crystal response time; acquiring a grayscale conversion timetable of the liquid crystal display screen, and obtaining a limit value of conversion time of the liquid crystal display screen according to the grayscale conversion timetable; acquiring a compensation grayscale lookup table of the display region for compensation; comparing the reserved liquid crystal response time and the limit value of conversion time to obtain a time comparison result; performing grayscale compensation on the display region according to the time comparison result, the grayscale conversion timetable and the compensation grayscale lookup table.

Abstract: A display driving control circuit, a display panel, and a driving control method are disclosed. A driving control sub-circuit in the display driving control circuit includes a first data selection sub-circuit, a second data selection sub-circuit, a third data selection sub-circuit, and a fourth data selection circuit. The first data selection sub-circuit, the second data selection sub-circuit, the third data selection sub-circuit, and the fourth data selection circuit are electrically connected to a first selection signal line respectively. The first data selection sub-circuit and the third data selection sub-circuit are electrically connected to a first data channel signal line, and the second data selection sub-circuit and the fourth data selection sub-circuit are electrically connected to a second data channel signal line.

Abstract: Embodiments of the present disclosure provide a method for driving a display panel, a driving device for driving a display panel and a display device. The display panel includes a first display region and a second display region each including first color sub-pixel units. The method includes obtaining a respective target grayscale of each of the first color sub-pixel units, obtaining a respective first gamma voltage of each of the first color sub-pixel units in the first display region based on the respective target grayscale, and providing the respective first gamma voltage to each of the first color sub-pixel units in the first display region, and obtaining a respective second gamma voltage of the first color sub-pixel unit in the second display region based on the respective target grayscale, and providing the respective second gamma voltage to each of the first color sub-pixel units in the second display region.

Abstract: A method and system for analyzing employee retention across an enterprise based on commuter modeling is disclosed. The method can be implemented in a computer system which includes: mapping longitudinal and latitudinal coordinates of address information of a plurality of employees and a work location onto a map, which shows a predefined geographic location encompassing the work location surrounded by the longitudinal and latitudinal coordinates of the address information; obtaining calculated analytics data of employee turnover rate for the plurality of employees based on a commute distance from the work location to each of the longitudinal and latitudinal coordinates of the plurality of employees; and graphically overlaying the analytics data of the turnover rate for the plurality of employees onto the map to show employee turnover rate for different segments of the map.

Abstract: A method, computer system, and computer program product for determining job levels of an employee within an organization. A computer system identifies employee data for the employee. The computer system determines whether the employee is a manager or a non-manager based on the employee data for the employee. The computer system applies a manager employee level model to determine a manager job level of the employee in response to determining that the employee is a manager. The computer system applies a non-manager employee level model to determine a non-manager job level of the employee in response to determining that the employee is a non-manager.